Weight loss injections
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Weight loss injections key facts
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Obesity is a common problem across the world and research has continued to search for treatments. One breakthrough has been the discovery of semaglutide-based drugs. These injectable medications, include Ozempic, Wegovy, Saxenda, Mounjaro, and Zepbound. Here, we will take a closer look at the benefits and differences of these weight loss injections.
Understanding semaglutide medications
Semaglutide is classed as a GLP-1 receptor agonist. It is the active ingredient in medications, such as Ozempic, Wegovy, Mounjaro, and Zepbound. Semaglutide mimics glucagon-like peptide-1 (GLP-1) hormones in the body, helping individuals feel full and satisfied after meals, leading to a reduced food intake and weight loss.
Ozempic
Ozempic was originally developed for the treatment of type 2 diabetes but has gained attention for its off-label use as a weight loss medication. Ozempic contains semaglutide as its active ingredient, which acts like the glucagon-like peptide-1 (GLP-1) hormone in the body. Ozempic increases the production of insulin, which signals the feeling of fullness in the brain, helping individuals to effectively lose weight.
Wegovy and Saxenda
Wegovy (semaglutide) and Saxenda (liraglutide) are also brand-name injectable medications designed for healthy weight loss. Both contain a GLP-1 agonist and work by decreasing appetite, helping individuals reduce their calorie intake to achieve weight loss. Both Wegovy and Saxenda are used in combination with a reduced-calorie diet and increased physical activity.
Wegovy
In June 2021, Wegovy was approved by the FDA in the U.S. specifically for chronic weight management. Wegovy contains higher doses of semaglutide compared to Ozempic and is used in adults and children 12 years of age and older with obesity, who have a BMI (body mass index) greater than or equal to 30, or excess weight, with a BMI greater than or equal to 27, and also have other weight-related medical problems. Wegovy is a once-weekly injection, used in combination with a reduced-calorie diet and exercise.
Saxenda
Saxenda is also a GLP-1 receptor agonist, containing liraglutide as its active ingredient. It is used in adults with obesity (BMI greater than or equal to 30) or excess weight (BMI greater than or equal to 27) who have other weight-related medical problems, as well as children, 12 to 17 years of age, with a body weight above 132 pounds (60 kg) and obesity. Saxenda is injected under the skin, subcutaneously, in the abdomen, thigh, or upper arm.
How to use Wegovy and Saxenda?
Both Wegovy and Saxenda are administered as subcutaneous injections, once a week. You must follow the instructions provided in your medication guide and by your healthcare provider. Injection sites should be rotated to reduce the risk of pits and lumps forming under the skin.
Mounjaro
Mounjaro contains tirzepatide, but is used for the management of type 2 diabetes. Off-label however, Mounjaro has shown to cause significant weight loss. Mounjaro helps to regulate blood sugar levels and reduce food intake, and is an alternative weight loss medication for those with diabetes.
Zepbound
Zepbound also contains tirzepatide and is approved by the FDA in the U.S. for chronic weight management. In clinical trials individuals using Zepbound experienced significant weight loss, with some losing almost 20% of their body weight. Zepbound is a promising option for those seeking weight loss.
Comparing semaglutide medications
While Ozempic and Wegovy share the same active ingredient, they are approved for different uses. Ozempic is indicated for type 2 diabetes, while Wegovy is approved for weight management.
Mounjaro and Zepbound also contain the same active ingredient, tirzepatide, but Mounjaro is used for the treatment of diabetes and Zepbound is used for weight management. Speak to a healthcare professional to determine the most suitable medication based on your needs.
Dosage and administration
Dosages and administration will vary depending on the specific drug being used. Both Ozempic and Wegovy are administered once weekly. Ozempic dosing starts at 0.25 mg, gradually increasing to 1 or 2 mg to control blood sugar levels. Wegovy starts at 0.25 mg, increasing to 1.7 mg after four months, and finally to 2.4 mg from month five onwards. Mounjaro, Saxenda and Zepbound have their own guidelines for dosing, which should be followed by healthcare professionals and yourself.
Effectiveness and benefits
The benefits of weight loss can lead to a reduced risk of other health conditions, such as heart disease, type 2 diabetes, and other weight-related conditions. Semaglutide medications offer a potential solution for people struggling with obesity or being overweight.
Important safety information
Before using these weight loss treatments, it is important to understand the risks associated with these medications. Speak to a healthcare provider to determine if these are safe for you.
Thyroid tumours and cancer
These medications have been linked to an increased risk of thyroid tumours, including thyroid cancer. Symptoms include a lump or swelling in the neck, difficulty swallowing, or shortness of breath. These medications should not be used if you have a history of thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Allergic reactions
Symptoms of an allergic reaction include swelling of the lips, face, tongue, or throat, trouble breathing or swallowing; severe rash or itching; fainting; or rapid heartbeat. Seek medical help immediately, if you experience any of these symptoms.
Pancreatitis
Pancreatitis (inflammation of the pancreas) is a potential side effect of both Wegovy and Saxenda. Symptoms include severe pain in the abdomen that does not go away, with or without vomiting. Contact your healthcare provider immediately if you experience these symptoms.
Gallbladder problems and gallstones
Symptoms of gallbladder problems may include nausea, vomiting, severe stomach pain, fever, yellowing of the skin or eyes, or clay-coloured stools. Speak to your healthcare provider if you experience any of these symptoms.
Risk of low blood sugar
GLP-1 receptor agonists may increase the risk of low blood sugar in patients with type 2 diabetes, especially when used with other diabetes medications such as sulfonylureas or insulin. Discuss how to recognize and treat low blood sugar, as well as how to monitor your blood sugar levels with your healthcare provider.
Kidney problems
You may be at an increased risk of kidney failure when using GLP-1 receptor agonists, if you have kidney problems. Kidney problems may become worse if you experience dehydration caused by diarrhoea, nausea, or vomiting. It is vital to stay hydrated and report any symptoms of kidney problems, such as decreased urine or swelling of the ankles, hands, or feet.
Other Precautions
Before starting treatment, inform your healthcare provider about any other medical conditions you may have, such as a history of depression or mental health issues, if you are pregnant or planning to become pregnant. Also, disclose all medications you are taking to your healthcare provider, as certain medications may interact with GLP-1 receptor agonists.
Side effects and considerations
The most common side effects include nausea, diarrhoea, vomiting, constipation, stomach pain, headache, tiredness, upset stomach, loss of appetite, bloating, belching, gas, heartburn, and respiratory symptoms.
These medications may also cause serious side effects, such as pancreatitis, gallbladder problems, low blood sugar, kidney problems, allergic reactions, changes in vision, increased heart rate, depression, and thoughts of suicide.
Additional lifestyle changes
These medications are most effective when used in conjunction with lifestyle changes. A healthy balanced diet, regular physical activity, and behaviour modifications can enhance weight loss with these medications.
Conclusion
By following a reduced-calorie diet, increasing physical activity, and following prescribing guidelines and injection regimens, you may be able to achieve and maintain weight loss. Speak to your healthcare provider when considering the risks and benefits of using weight loss injections and remember to stay informed about possible side effects and to report any concerns to your healthcare provider.
Service Guide
Everything you need to know about Getting Treated Privately
What does the Get Treated Privately service do?
The Get Treated Privately service is a private prescribing service which is designed for adults aged 18 years and over, who are experiencing health issues and who would like to receive a fast-track assessment and if applicable, a treatment plan from a qualified prescribing clinician. Treatments are dispensed and delivered to your home or workplace from our regulated online pharmacy.
Is this a safe service?
Yes. Our formulary of medications prescribed and conditions treated are controlled, governed, and continuously risk-assessed by our Medical Director, Dr. Aseel Hamoud. Unlike other prescribing services which operate using faceless questionnaires, our service is conducted through remote video consultations, also known as synchronous consultations. This builds patient safety and prescribing appropriateness into our service, ensuring our prescribing clinicians can be satisfied with who and what they are treating. There is no guarantee of supply of medications, and any prescriptions supplied are at the sole discretion of our clinician prescriber. There is no charge for the consultation.
What is a prescribing clinician and is it safe for me to use them on the NowPatient platform?
Our prescribing clinicians are board-certified pharmacists, nurses, or doctors who can also prescribe any medicine for any medical condition, subject to accepted accreditation and good clinical practice. They are all registered with their respective regulatory bodies. For example, a pharmacist independent prescriber is registered with the General Pharmaceutical Council (GPhC). Each prescribing clinician undergoes an extensive background check including a disclosure and barring service check (DBS). In addition, they undergo a rigorous license verification process. When you book an appointment with our prescribing clinicians you will see their full name, license number, and any specialized credentials they have.
Is the service available worldwide?
Yes, the Get Treated Privately service is available worldwide.
Do I need to pay for this service?
Yes. This is a private service. You do not need to pay for the consultation. You only pay for the cost of the medication you are prescribed.
How do I book a consultation?
Once you have logged into your account, you will need to navigate to the Get Treated Privately service card which is located as a service item on the dashboard.
Using the action button on the service card, you can select one of the following – ‘Search Treatments’ or ‘Search Conditions’.
Depending on the search type and the product/condition that you would like to get treated, you will be taken to a consultation booking screen. Follow the simple steps to complete your booking. During the booking confirmation, you will be able to select a date and time that is convenient for you, along with the preferred language and gender of the prescribing clinician you wish to choose. You will then see a list of all available expert clinicians who are trained to assess the medication or condition chosen. Once you have confirmed your booking, you will see a summary of the appointment including preliminary information about the consultation. At this point, you will also be able to add a reminder to your calendar. Always ensure your account health profile is up to date before any consultation. This ensures that our clinicians have the most up-to-date information about your current health status and anything that may influence their prescribing decisions. You will receive a push notification, SMS notification and email reminding you of your consultation, 30 minutes before the virtual consultation is due to start.
Depending on certain medications which require our clinicians to have your up-to-date blood pressure readings, you may be required to submit a virtual blood pressure check, using your smartphone or device. We will provide you with full instructions, when this is required.
What happens during the remote video consultation?
During the consultation, the clinician will ask you a series of questions that will allow the clinician to assess your condition and potential treatment options. At the end of the consultation, the clinician will decide if a treatment is a safe and suitable option for you. If it is, the clinician will discuss the various treatment options that may be available, so that you can jointly agree on the option that is most suited to you. Once you have jointly agreed on a treatment plan, the clinician will issue a prescription order which will be available in your Cart at the end of the consultation.
Also, with your consent, the clinician may wish to inform your doctor of the treatment that was prescribed. We recommend that you agree to this since your doctor is responsible for your overall care and they should have a record of this consultation and medication prescribed. In addition, our clinician may take the opportunity to advise you on your overall health including advice on healthy living or stop smoking.
What happens at the end of the consultation?
At the end of the consultation, you will receive a notification which will summarise the outcome. It will also advise you if any referrals were made to your doctor, along with any other advice that was given to you by the clinician.
If a referral letter was issued to your doctor, you will be able to view a copy of this in the ‘Documents’ section of the dashboard. If you were prescribed a treatment, it will now be available in your Cart.
When you go to your Cart, you will be able to select the treatment, checkout and make payment. Once the checkout is complete, your prescription order will be sent to our regulated online pharmacy for processing.
What if the prescriber does not prescribe what I want?
We operate a safe prescribing service. This means that our prescribing clinicians always exercise their clinical judgment when prescribing. Unfortunately, we do not operate a self select service where you can choose a medication and simply buy. If the clinician that sees you does not prescribe anything, then you will not be charged.
Will I get status updates for my order?
Yes. When your treatment is approved, and after you have checked out and paid for your order, we will keep you fully updated with the status of your order. Every time the status of your order changes, you will be notified immediately. These notifications will appear in the ‘Notification Feed’ section on the dashboard.
How will my order be delivered?
All orders are shipped in discreet and unmarked packaging. This means it is suitable for delivery wherever you require (home, work, or a neighbour).
For thermo-sensitive orders (e.g. Insulin or weight loss injections) we use cold chain-validated packaging. Your parcel will normally receive an estimated delivery window from the courier on the day of delivery.
For your protection and safety, your first order can only be delivered to the address that is registered with NowPatient. Future orders can be delivered to any other address, for example, your workplace.
Do you ship cold-chain or temperature sensitive products?
Yes. We use a specialist courier service for all thermo-sensitive deliveries. This is to ensure that cold chain integrity is always maintained and thus the product quality, safety and efficacy.
Learn more about how we handle the delivery of temperature sensitive products.
Where do you deliver?
We currently deliver to all postcodes/zipcodes worldwide. Some postcodes in rural areas may have a slightly longer delivery time.
When will my order arrive?
We aim to ship all orders placed Monday – Friday before 3pm on the same day. Orders placed outside these times will be shipped the next working day. All deliveries are shipped by Royal Mail, which delivers Monday through Saturday in the UK. For deliveries outside of the UK, please check with your national postal service for accurate delivery days.
Our delivery options have the following delivery times:
- UK – Royal Mail Tracked 24 & Signed for Delivery – Next day delivery
- Europe – Royal Mail Tracked – Typical delivery of 3-5 working days
- Worldwide – Royal Mail – Typical delivery of 5-7 working days. If a tracked option is available for your country via Royal Mail, this service will be applied.
What should I do if my order has not arrived?
Delivery is normally made promptly after your dispatch notification is received. You can check the tracking details of your order in the ‘Notification Feed’ section of the dashboard, at any point after dispatch.
Unfortunately, packages can sometimes get lost in the delivery system. If after 10 days you have not received your delivery, please contact us and we will do all we can to resolve the problem.
Can you prescribe GLP-1 weight loss injections?
Yes. However, with GLP-1 weight loss medications, the license requires that there are support resources put in place as part of the plan including coaching for a healthy lifestyle, exercise, and diet. Our clinicians will discuss this with you, if you are prescribed this type of treatment.
You can learn more on our Weight Loss Programs feature page.
What’s included with my order?
If you are ordering prescription medication, your order will contain your medication only.
If you are ordering weight loss injections, your order will contain:
- Your prescription of pre-filled weight loss injection pens
- Needles
- Sharps bin for safe disposal of needles (if ordered as part of the bundle)
Can I reorder my medication, if I have already been prescribed a course?
Yes. However, as a responsible prescribing service, we do not issue more than one monthly cycle of medication at a time. This means that, if you would like to reorder, you will need to rebook a consultation.
This is important, because it allows our clinicians to keep track on the progress of your treatment plan and ensure that the medication remains safe and effective for you.
What is the earliest I can reorder my medication or treatment?
14 days after you have received your first monthly supply, we will send you a notification to advise you that you are eligible to reorder your medication. To ensure that we are able to safely prescribe the next supply, you will need to rebook a consultation.
This ensures that our clinician can check in on your treatment plan and ensure it is working as intended and continues to be safe, suitable and appropriate for you.
How do I reorder my medication?
When you are eligible to reorder your next medication, we will send you a notification reminder. This notification reminder will request that you book a consultation with a NowPatient Clinician.
You should book a suitable time and date for the consultation.
At the end of the consultation, the clinician may advise you to either
- Stop the treatment
- Stay on the current dose
- Increase the dose
If our clinician deems it safe for you to continue taking the medication, the medication will be added to your cart, from where you can checkout.
Delivery will be made in line with our delivery timescales.
As a responsible prescribing service, we will always monitor your treatment plan to ensure that it remains safe, effective and suitable for you.
How do I reorder weight loss medication?
Our weight loss programs are built to closely monitor treatment progress and safety. Please refer to the Weight Loss Programs Service Guide that explains how you can reorder or step edit your dose.
About Telehealth
Everything you need to know about video consultations
Are remote video consultations right for me?
How do I know if the remote video consultation service is safe?
Do I need to verify my identity during the remote video consultation?
Can I have a chaperone (carer, friend, family member) join a remote video consultation?
How can I be sure that you are handling and protecting my data securely?
How is my data stored?
Are my consultations confidential?
Can I select which clinician I have my consultation with?
Will my doctor be informed of any consultations I have through the app?
Do remote video consultations save money for health systems?
Are remote video consultations safer than online questionnaires?
What quality of care can I expect to receive from a remote video consultation?
Why am I being asked to provide my Blood Pressure reading?
If I don’t have a Blood Pressure monitor, how can I provide my readings?
Is the remote blood pressure monitor safe and medically accurate?
How does the remote blood pressure monitor actually work?
When and how is my remote blood pressure reading taken?
What devices does the remote Blood Pressure monitor work on?
Why do my results keep failing when using the remote blood pressure monitor service?
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