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Can I get sagging skin when using GLP-1 weight loss injections

Can I get sagging skin when using GLP-1 weight loss injections

Rajive Patel NowPatientGreen tick
Updated on 10 Nov 2023

In recent years, GLP-1 (glucagon-like peptide-1) weight loss injections have gained popularity as a treatment for obesity and diabetes. These FDA-approved (Food and Drug Administration) brand-name medications, such as Ozempic, Wegovy, and Rybelsus, belong to the GLP-1 receptor agonist class. They work by mimicking the action of GLP-1, a hormone that regulates appetite and promotes weight loss. However, there have been concerns about the potential side effect of sagging skin, widely called on social media as “Ozempic face” or “Ozempic butt” much like patients after bariatric surgery. In this article, we will delve into the topic to understand whether GLP-1 weight loss injections can indeed cause sagging skin and explore potential strategies to manage this side effect.

The mechanism of GLP-1 weight loss injections

GLP-1 weight loss injections are designed to help individuals with obesity or type 2 diabetes achieve body weight loss. These medications act on the GLP-1 receptors in the body, which are primarily located in the pancreas, intestines, and brain. By activating these receptors, GLP-1 medications increase insulin secretion, reduce blood sugar levels, decrease glucagon release, slow down gastric emptying, and promote satiety, leading to reduced food intake and weight loss.

Rapid weight loss and its effects on the skin

One of the primary concerns with rapid fat loss, whether achieved through weight loss medication or other methods, is its impact on the skin. When a person loses a significant amount of weight quickly, the skin may not have enough time to adapt and tighten, resulting in loose or sagging skin. This is particularly true for areas with a higher concentration of fat, such as the face and buttocks.

Understanding “Ozempic Face” and “Ozempic Butt”

The terms “Ozempic face” and “Ozempic butt” have gained attention in online discussions and tiktok surrounding GLP-1 weight loss drugs. These terms describe the potential changes in the appearance of your face and buttocks due to losing a lot of weight with medications like Ozempic (semaglutide). Ozempic users have reported a reduction in facial volume and fat, resulting in wrinkles, sagging skin and excess skin. Similarly, the buttocks may also experience a loss of volume and firmness.

Managing sagging skin from GLP-1 weight loss injections

While the potential for sagging skin is a concern for individuals using GLP-1 weight loss injections, there are strategies to manage this side effect. It’s important to note that every individual’s experience may vary, and consulting with a healthcare professional is crucial for personalized advice. Here are some potential approaches to consider:

1. Gradual weight loss

One strategy to minimize the risk of sagging skin is to aim for gradual weight loss rather than significant weight loss rapidly. By losing weight at a slower and more sustainable pace, the skin has a better chance to adapt and tighten naturally. This approach allows for collagen production and skin elasticity to catch up with the changes in body composition.

2. Strength training and muscle building

Incorporating strength training exercises into your weight loss journey can be beneficial for maintaining muscle mass and improving body composition. By building lean muscle, you can help fill out loose skin and create a more toned appearance. Focus on exercises that target the areas of concern, such as facial exercises or glute-focused workouts.

3. Hydration and skincare

Experts say keeping your skin well-hydrated is essential for maintaining its elasticity and promoting overall skin health. Drink plenty of water and use moisturizers that are suitable for your skin type. Additionally, practicing a consistent skincare routine can help improve the appearance of sagging skin. Look for products that promote collagen and elastin production and contain ingredients like retinol, hyaluronic acid, and peptides, which are known for their skin-tightening properties. It may be beneficial to speak to a dermatologist before commencing Ozempic treatment.

4. Non-surgical cosmetic procedures

For individuals experiencing more significant sagging skin, non-surgical cosmetic procedures can be an option to consider. These procedures, performed by qualified professionals, can help restore volume and tighten the skin. Dermal fillers, radiofrequency treatments, and laser therapies are among the options that may be recommended based on individual needs and goals.

5. Surgical interventions

In cases where non-surgical methods are not sufficient, surgical interventions such as plastic surgery may be considered. Procedures like facelifts, neck lifts, and body contouring surgeries can address loose and sagging skin more extensively. It’s important to consult with a board-certified plastic surgeon to discuss the potential risks, benefits, and expected outcomes of these procedures.


GLP-1 weight loss injections have shown promising results in helping individuals with weight management. While concerns about sagging skin, often referred to as “Ozempic face” or “Ozempic butt,” have been raised, it’s important to approach this potential side effect with a balanced perspective. Gradual weight loss, strength training, skin care, and non-surgical or surgical interventions can all play a role in managing sagging skin. Remember to consult with a healthcare professional to determine the best approach for your individual needs and goals.

Disclaimer: This article is for informational purposes only and should not replace professional medical advice. Always consult with a healthcare professional before starting any weight loss program or making changes to your medication regimen.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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