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What are the benefits of Amycretin?

What are the benefits of Amycretin?

Daniel Cheung NowPatientGreen tick
Updated on 15 Mar 2024

Losing weight can be a challenging journey for many individuals struggling with obesity. While traditional weight loss methods have proven effective, there is always room for improvement. In recent years, the emergence of new experimental weight loss pills has sparked excitement in the medical community. One such pill, Amycretin is a GLP-1 and amylin receptor agonist. It is developed by Danish drugmaker Novo Nordisk and has shown promising results in early trials, surpassing the efficacy of existing injectable treatments like Ozempic, Wegovy, and Mounjaro. In this article, we will explore the potential benefits of Amycretin as a more potent and convenient solution for weight loss.

Understanding Amycretin and its mechanism

Amycretin is an oral obesity drug that aims to address the needs of individuals who dislike needles. Unlike its injectable counterparts, such as Ozempic and Wegovy, Amycretin comes in tablet form. The drug harnesses the power of two hormones, GLP-1 and amylin, to promote weight reduction. GLP-1 is a gut hormone that triggers a feeling of fullness, reduces appetite, and boosts insulin release. On the other hand, amylin plays a role in appetite regulation and satiety. By combining these two hormones, Amycretin offers a unique approach to weight loss.

The promise of Amycretin: Early trial results

Early trial results of Amycretin have created a buzz in the medical community. In a placebo-controlled clinical trial spanning three months (phase 1), participants taking Amycretin experienced a remarkable 13% weight loss, more than twice the amount seen with Ozempic and Wegovy. These outcomes have led experts to consider Amycretin as a potentially more exciting weight management solution. However, it is important to note that these results are from short-term studies, and further research is needed to assess the long-term effectiveness and safety of Amycretin. A larger phase 2 trial is planned for the second half of this year, with results expected in around 2026.

Comparison with existing treatments

To understand the true potential of Amycretin, it is essential to compare its effectiveness with existing weight loss treatments. Ozempic and Wegovy, both brand names for the compound semaglutide, have been widely used to address obesity. These drugs mimic GLP-1 and have shown success in promoting weight loss. Semaglutide can lead to a loss of approximately 15% of body weight after one year of use. However, weight tends to plateau, requiring long-term injections for sustained results. Mounjaro, another weight loss injection, has also shown promise, leading to about 21% weight loss over the first year and five months.

In comparison, amycretin’s early trial results demonstrate a 13% weight loss over three months, surpassing the efficacy of Ozempic, Wegovy, and Mounjaro during the same period. However, it is crucial to recognize that these comparisons are based on separate trials, and a head-to-head study is necessary to provide accurate insights into the relative effectiveness of these drugs.

Safety profile and side effects

One of the advantages of drugs that mimic GLP-1 is their well-understood safety profile. Ozempic, Wegovy, and Mounjaro have been used for over a decade to treat type 2 diabetes, allowing for a comprehensive understanding of their potential risks and side effects. However, Amycretin introduces a different hormone, amylin, which may have unique implications. While Novo Nordisk, the manufacturer of Amycretin, has reported similar side effects to Wegovy, including nausea, vomiting, and diarrhea, more research is required to fully comprehend the safety profile of Amycretin.

The appeal of oral pills: Convenience and patient preference

The availability of Amycretin in tablet form presents a significant advantage for individuals who prefer oral administration over injections. For those who dislike needles, an oral weight loss pill can be a game-changer.

Future developments: Expanding the options

Drug development of Amycretin as a potential weight loss solution opens the door to further exploration of gut hormone mimicry. While Amycretin focuses on GLP-1 and amylin, other weight-loss drugs targeting different gut hormones are also under development. These advancements in medical research offer hope for individuals struggling with obesity, providing a range of treatment options tailored to their specific needs.


Amycretin, an experimental obesity pill, shows promise as a more potent alternative to existing injectable treatments. Early trial results demonstrate its potential to induce significant weight loss, exceeding the efficacy of Ozempic, Wegovy, and Mounjaro over three months. However, further research is required to assess its long-term effectiveness and safety. With its oral administration and unique combination of gut hormones, Amycretin presents a convenient and potentially more attractive option for individuals seeking weight loss solutions. As medical advancements continue, the future holds exciting possibilities for the treatment of obesity.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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