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What diet plan should I use with Wegovy or Mounjaro

What diet plan should I use with Wegovy or Mounjaro

Rajive Patel NowPatientGreen tick
Updated on 10 Nov 2023

When it comes to weight loss, finding the right diet plan can be a game-changer. With the advent of new medications like Wegovy and Mounjaro, individuals struggling with obesity or overweight now have additional options to aid in their weight loss journey. While these medications show promise in promoting weight loss, it’s important to note that they should be used in conjunction with a healthy and balanced diet. In this article, we will explore the best diet plans to consider when using Wegovy or Mounjaro, along with some tips to help you achieve your weight loss goals.

Understanding Wegovy and Mounjaro

Before delving into the diet plans, let’s briefly recap what Wegovy and Mounjaro are and how they work.


Mounjaro is a prescription brand-name medication developed by Eli Lilly that has shown significant potential for weight loss. It is a dual-acting GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist. These hormones play crucial roles in regulating blood sugar levels and appetite.

Mounjaro, also known by its generic name tirzepatide, is a groundbreaking medication. It is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. The drug is FDA-approved (U.S. Food and Drug Administration approved) for the treatment of type 2 diabetes.

In clinical trials evaluating Mounjaro’s use for weight management, it has demonstrated the highest amount of weight loss compared to other medications. At the highest dose, Mounjaro has led to a body weight loss of about 21% to 22.5%. Some clinicians have noted that these numbers approach the weight loss seen with bariatric surgery. It is important to note that Mounjaro is not yet specifically approved by the FDA (Food and Drug Administration) for weight loss.


Wegovy is a brand-name prescription drug manufactured by Novo Nordisk. It is used for chronic weight management. It is for use specifically in those with a body mass index (BMI) of 27 kg/m 2 or more with a weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol. or in those with a BMI of 30 kg/m 2.

Wegovy contains the active ingredient semaglutide given as a once-weekly injection. Wegovy is a higher dose of the same drug as Ozempic that is approved as a diabetes medication.

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in Wegovy as a weight loss drug. GLP-1 receptor agonists are found in the intestines, pancreas and brain and are part of the body’s hormone system, which regulates appetite, making it an effective target for treating obesity. When semaglutide binds to GLP-1 receptors, insulin secretion increases, reducing food intake by decreasing cravings and slowing gastric emptying.

In clinical trials, treatment with semaglutide led to significant weight loss in obese patients when combined with healthy lifestyle changes such as calorie restriction and increased physical activity. As a result, semaglutide is becoming increasingly popular as a medically supervised weight loss therapy.

Side effects

The most common side effects of both medications are short-lived gastrointestinal issues such as nausea, vomiting, constipation, diarrhea and stomach pain. Mounjaro and Wegovy also carry a small risk of thyroid C-cell tumors and more serious side effects like pancreatitis or gallbladder disease.

The importance of a healthy diet

While Wegovy and Mounjaro can aid in weight loss, it’s crucial to adopt a healthy diet to maximize their effectiveness. It is important to remember that Wegovy is approved as a weight loss medication but Mounjaro is not. However, healthcare providers may prescribe it off-label for this purpose. A well-balanced diet not only supports weight loss but also contributes to overall health and well-being. Here are some key principles to keep in mind when designing a diet plan to complement the use of Wegovy or Mounjaro:

Caloric deficit

Creating a caloric deficit is essential for weight loss. When you consume fewer calories than your body needs, it will start utilizing stored fat for energy, leading to weight loss. Calculate your daily caloric needs based on your age, gender, weight, and activity level, and aim to consume slightly fewer calories to create a deficit.

Macronutrient balance

Aim for a balanced intake of macronutrients: carbohydrates, proteins, and fats. Carbohydrates provide energy, proteins support muscle growth and repair, and fats are essential for hormone production and nutrient absorption. Include a variety of whole grains, lean proteins, and healthy fats in your diet.

Portion control

Even with the use of Wegovy or Mounjaro, portion control is crucial. Be mindful of your serving sizes and avoid overeating. Using smaller plates and measuring portions can help control your intake and prevent excessive calorie consumption.

Emphasize whole foods

Focus on consuming whole, nutrient-dense foods such as fruits, vegetables, lean proteins, whole grains, and healthy fats. These foods are generally lower in calories and provide essential vitamins, minerals, and fiber.

Limit processed foods

Processed foods are often high in calories, unhealthy fats, added sugars, and sodium. Minimize your consumption of processed snacks, sugary beverages, fast food, and pre-packaged meals. Opt for homemade meals made from whole ingredients whenever possible.

Diet plans

Now that we understand the importance of a healthy diet, let’s explore some specific diet plans that can complement the use of Wegovy or Mounjaro. These diet plans are known for their effectiveness in promoting weight loss and overall health:

Mediterranean diet

The Mediterranean diet is a well-known eating pattern that emphasizes whole foods, lean proteins, healthy fats, and plenty of fruits and vegetables. This diet has been associated with numerous health benefits, including weight loss, improved heart health, and reduced risk of chronic diseases.

The Mediterranean diet encourages the consumption of:

  • Fruits and vegetables: Aim for at least five servings of fruits and vegetables per day
  • Whole grains: Choose whole-grain bread, pasta, and cereals
  • Lean proteins: Include fish, poultry, legumes and nuts
  • Healthy fats: Use olive oil as your primary cooking oil and incorporate sources of healthy fats like avocados and nuts
  • Moderate dairy: Opt for low-fat dairy products like Greek yogurt and feta cheese
  • Limited red meat: Consume red meat in moderation and choose lean cuts

DASH diet

The DASH (Dietary Approaches to Stop Hypertension) diet is a well-researched eating plan designed to lower blood pressure. It focuses on consuming foods that are low in sodium and high in nutrients. The DASH diet has also been shown to support weight loss and improve overall health.

The DASH diet encourages the consumption of:

  • Fruits and vegetables: Aim for several servings of fruits and vegetables each day
  • Whole grains: Choose whole-grain bread, rice, and pasta
  • Lean proteins: Include lean meats, poultry, fish, and legumes
  • Low-fat dairy: Opt for low-fat milk, yogurt, and cheese
  • Nuts and seeds: Incorporate unsalted nuts and seeds for added nutrition
  • Limited sodium: Minimize your intake of high-sodium foods like processed snacks, fast food, and canned soups

Flexitarian diet

The flexitarian diet is a flexible approach to eating that encourages plant-based foods while allowing for occasional consumption of meat and animal products. This diet plan focuses on whole foods and supports weight loss, improved heart health, and reduced risk of chronic diseases.

The flexitarian diet encourages the following:

  • Plant-based proteins: Incorporate beans, lentils, tofu, tempeh, and other plant-based proteins into your meals
  • Fruits and vegetables: Aim for a variety of colorful fruits and vegetables
  • Whole grains: Choose whole grain bread, rice, quinoa, and oats
  • Healthy fats: Use olive oil, avocados, and nuts as sources of healthy fats
  • Limited meat and animal products: Reduce your consumption of meat and animal products, reserving them for occasional treats

Intermittent fasting

Intermittent fasting is an eating pattern that cycles between periods of fasting and eating. It has gained popularity for its potential benefits in weight loss, improved insulin sensitivity, and cellular repair. There are several approaches to intermittent fasting, including the 16/8 method, where you fast for 16 hours and have an 8-hour eating window.

During the eating window, focus on consuming balanced meals that include adequate protein, healthy fats, and fiber-rich carbohydrates. Avoid overeating during the eating window to maintain a caloric deficit.

Tips for success

Regardless of the diet plan you choose, incorporating these tips can enhance your weight loss journey when using Wegovy or Mounjaro:

Stay hydrated

Drink plenty of water throughout the day to stay hydrated and support your body’s natural functions. Water can also help control hunger and prevent overeating.

Mindful eating

Practice mindful eating by paying attention to your body’s hunger and fullness cues. Eat slowly, savoring each bite, and stop eating when you feel satisfied.

Regular physical activity

Combine your diet plan with regular physical activity to maximize weight loss and improve overall fitness. Engage in activities you enjoy, such as walking, jogging, cycling, or strength training.

Seek professional guidance

Consult a healthcare professional or registered dietitian for personalized guidance and support. They can help tailor a diet plan to your specific needs and monitor your progress.


While Wegovy and Mounjaro provide promising options for weight loss, they should be used in conjunction with a healthy and balanced diet. The Mediterranean diet, DASH diet, flexitarian diet, and intermittent fasting are all effective diet plans to consider when using these medications. Remember to create a caloric deficit, focus on whole foods, practice portion control, and adopt healthy eating habits. Stay consistent, stay motivated, and seek professional guidance when needed. With the right diet plan and the support of these medications, you can achieve your weight loss goals and improve your overall health. Always inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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