Home
/
NowPatient Blog
/
What does MariTide do to your body?

What does MariTide do to your body?

Navin Khosla NowPatientGreen tick
Created on 17 Jul 2024
Updated on 18 Jul 2024

Amgen’s MariTide provides a groundbreaking weight loss drug as an alternative to Novo Nordisk’s Wegovy and Eli Lilly’s Zepbound.  In a Phase I trial, data suggest that Amgen’s maridebart cafraglutide (MariTide) may allow patients to take lower and less frequent doses over time while still maintaining significant weight loss. Let’s explore how MariTide works, its effects on the body, and insights into how it could revolutionize weight loss treatment, and provide future benefits.

Mechanism of action

MariTide has a dual mechanism of action, that affects both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This section looks into the specifics of how MariTide functions.

Maritide is designed to simultaneously activate the GLP-1 receptor and antagonize the GIP receptor, a unique combination that has shown promise in preclinical and early-stage clinical studies.

GLP-1 (glucagon-like peptide-1) is a hormone that plays a crucial role in regulating blood sugar levels and appetite. By activating the GLP-1 receptors, MariTide can enhance insulin secretion, slow gastric emptying, and promote feelings of fullness, leading to a reduced calorie intake and subsequent weight loss. On the other hand, GIP antagonism is an additional strategy, as it can further enhance the weight loss effects by reducing the body’s ability to store excess calories as fat.

The dual action of these two mechanisms is what sets MariTide apart from other obesity treatments currently on the market or in development. By targeting these pathways simultaneously, the molecule aims to deliver a more potent and durable weight loss response. This could potentially offer a more effective solution for individuals struggling with obesity.

Design of MariTide

MariTide is a bispecific molecule:

  • It has been designed by joining a fully human monoclonal anti-human GIPR antagonist antibody with two GLP-1 analogue agonist peptides. This structure allows MariTide to remain in the body longer compared to other weekly weight-loss injections

The interaction between MariTide and the receptors involves complex internal processes crucial for effective metabolic regulation in the body. Through these mechanisms, MariTide not only helps in weight loss, but also contributes to the overall metabolic health of individuals.

Effects on weight loss

Clinical trial outcomes

  • Initial weight loss:In phase 1 clinical trials published in the journal Nature Metabolism, MariTide showed significant weight reduction. Participants receiving the highest dose of 840 mg experienced an average weight loss of 8.2% by Day 92
  • Extended dosing results:Those in the multiple-dose arm, receiving 420 mg every 30 days for three months, saw an even more noticeable weight loss, averaging 14.5% by Day 85

Comparison with other GLP-1 agonists

  • Studies indicate that while competitors like Wegovy and Zepbound show 15% to 21% body weight loss after one year, MariTide offers more durable weight management without the significant weight rebound often associated with other treatments

Long-term efficacy and safety

  • The sustained efficacy of MariTide is highlighted by the maintenance of substantial weight loss, with participants maintaining a 11.2% reduction up to 150 days post-treatment. This suggests its potential as a long-term obesity management solution

Dosing flexibility

  • Early-stage data suggests that MariTide’s dosing could potentially be reduced and administered less frequently over time. This could provide a significant advantage in terms of patient compliance and ongoing management of obesity

Summary of weight loss benefits

  • MariTide not only initiates significant weight loss but also sustained weight loss over an extended period, placing it as a better option in the GLP-1 class of drugs for obesity management

Benefits beyond weight loss with GLP-1 drugs

  • Cardiovascular effects:GLP-1 agonists like semaglutide have shown a reduction in cardiovascular events in older patients with elevated HbA1c levels, though these benefits do not extend to decreased cardiovascular mortality
  • Neuroprotective effects:Liraglutide has the ability to cross the hematoencephalic barrier, offering neuroprotective effects that could be important in treating neurodegenerative diseases and aiding recovery
  • Blood pressure reduction:Early treatment phases with GLP-1 agonists such as exenatide and liraglutide have shown a reduction in blood pressure among diabetic patients. This effect can be explained due to the inhibition of the renin-angiotensin-aldosterone system and improvement in endothelial function
  • Enhanced endothelial responses:The direct activation of specific receptors in vascular tissue by GLP-1 agonists supports endothelial function, further contributing to cardiovascular health

Cardiovascular risk factors

  • GLP-1 agonists also regulate several other cardiovascular risk factors including endothelial dysfunction, arterial blood pressure, dyslipidemia, and platelet function. This additional affect suggests a broader therapeutic potential for MariTide beyond simple glucose regulation or obesity management

Long-term use of GLP-1 agonists

  • It is important to note that significant weight loss achieved through GLP-1 agonists can lead to rapid weight gain upon cessation of the drug. This underscores the need for careful management and potential long-term use considerations to maintain therapeutic benefits

Overview of safety and tolerability

MariTide, administered via a handheld auto-injector once a month or less, has demonstrated an acceptable safety profile across various clinical trials. The tolerability of MariTide is similar to other GLP-1 drugs, with manageable gastrointestinal side effects.

Common side effects

Gastrointestinal symptoms:

  • The most frequently reported side effects were mild nausea and vomiting
  • These symptoms were common but typically reduced after the initial doses

Comparison with other GLP-1 drugs:

  • The safety and side effects profile of MariTide matches closely with that of other drugs in the GLP-1 drug category, primarily involving gastrointestinal issues

Conclusion

We have looked at how MariTide, a promising obesity drug works through its dual mechanism of action with GLP-1 and GIP receptors. This unique approach sets MariTide apart in treating obesity and also provides alternative solutions for healthcare providers and patients.

In essence, Amgen’s drug MariTide represents a positive step forward in obesity treatment. As further research from ongoing Phase 2 clinical studies continue, it is anticipated that MariTide will make a valuable addition to the medications already available for the treatment of obesity.

 

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

 

FAQ logo

People Asked

Now Patient Data Security

Data Security

Our Commitment to You.

Learn moreNow Patient Data SecurityNow Patient Data Security

WHY WE BUILT NOWPATIENT

We are committed to helping everyone, everywhere live healthier lives

The NowPatient virtual care platform provides you with access to trusted health information, affordable treatments, management of chronic health conditions and continuous monitoring for health risks. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A laptop screen displays a dashboard with various health metrics and notifications. Widgets include drug coupons, home health testing, genetic risk, diabetes risk, BMI, pollen meter, and air quality.

Your Questions Answered

For your peace of mind, we can answer your questions quickly

What does NowPatient do?

NowPatient is an online pharmacy & telehealth service that is available in the US and UK. Our service is FREE and packed with useful features that can help you save money on the cost of your medications, access virtual treatments, and provide tools that can help improve your overall health.

Get started today and benefit from medication remindersGet Treated PrivatelyNHS online pharmacyGP appointment bookingRx savings cardDrug CouponsUS drug savings programshealth conditions informationgenetic testinghome test kitsBMI RisksType 2 Diabetes Riskspollen meterair quality monitor, and lots more!

Our service is operated by experienced medical professionals in the United States and the United Kingdom. You can view the online services that we provide by clicking Features.

UK users can safely and securely buy medicines online that treat a wide range of medical conditions. UK customers can also order NHS prescriptions online with the benefit of free tracked delivery.

US customers, regardless of insurance coverage, can enjoy huge savings on prescription medications using our various drug savings programs including drug coupons, savings card and manufacturer-sponsored patient assistance programs.

Where is NowPatient located?

NowPatient has offices in the United Kingdom and United States.

In the UK, we are located at:

NowPatient
28 Chipstead Valley Road
Coulsdon
Surrey
CR52RA

In the US, we are located at:

NowPatient
8911 North Capital of Texas Highway
Suite 4200 #1263
78759
Austin, TX

How can I contact NowPatient?

To contact NowPatient, please use the contact form available on the Contact Us page.

Alternatively, if you need to speak to us, you can reach us on the following numbers:

UK telephone number – 020 388 51 500
US telephone number – 1-866-967-1977

Who owns NowPatient?

NowPatient is owned and operated by Infohealth Ltd, a licensed online pharmacy with services spanning the UK, US and Rest of the World. Infohealth Ltd is registered in England and Wales under company number 04004930 and our registered office is at Lynwood House, 373 – 375 Station Road, Harrow, England, HA1 2AW.

Our website is www.nowpatient.com. Our App is called “NowPatient” and can be downloaded from the App Store (for Apple devices) or Google Play (for Android devices).

Can you tell me more about your NHS online pharmacy?

NowPatient’s Pharmaceutical services in the UK are provided by Infohealth Limited trading as ‘Infohealth Pharmacy’.

Our dispensing pharmacy is regulated and authorized for internet sales by the General Pharmaceutical Council (GPhC), registration number 1036487. You can view our license credentials on the General Pharmaceutical Council website. Our superintendent pharmacist who is responsible for the safe and effective oversight of medicines supplies is Mr Amish Patel (Registration Number 2042705).

Medicines are not ordinary items of commerce. All medicines or healthcare product sales are made under the supervision of a registered pharmacist who is licensed by the GPhC. At all times, we endeavour to provide a professional and transparent service whose primary goal is to ensure that the best interests of the patient are served.

How do I make a complaint?

From time to time, we accept that our service levels may not be up to your expectations. NowPatient welcomes concerns, compliments and complaints as valuable feedback that will help us learn from your experiences and make improvements. Feedback can be provided via our clear and transparent Complaints Procedures.

Can you tell me more about NowPatient’s prescribing services for treatments offered?

Our prescribing services are regulated by the General Pharmaceutical Council (GPhC). We provide the following regulated activity:

• treatment of disease, disorder, or injury
• transport services, triage, and medical advice are provided remotely
• caring for adults over 65 years old
• caring for adults under 65 years old

NowPatient prescribing services are run by Infohealth Limited. The Clinical Safety Officer and nominated individual is Mr Navin Khosla.

Can you tell me more about NowPatient’s US services?

Our head of US services is Dr. Jamie Winn.

You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.

We do not provide any prescribing services or dispensing services in the United States.

Is NowPatient legit and can I trust information from NowPatient?

Yes. NowPatient provides trustworthy and accessible clinical, health education and prescription services. We are also trusted by the NHS to deliver clinical and NHS repeat prescription dispensing across the whole of England. In the United States, we work with over 65,000 pharmacies to deliver considerable costs savings for our users.

NowPatient is operated by experienced licensed medical professionals in the United Kingdom and United States. Our Medical Team can be found here.

Our service is trusted by thousands of patients worldwide. You can read their reviews on our Trustpilot:

NowPatient Trustpilot

What are NowPatient’s opening hours?

Our office hours are:

UK – Monday-Friday 9am-6pm GMT
US – Monday-Friday 8am-5pm EST

Please note that we are closed at weekends.

In the event of a medical life-threatening emergency please call:

UK – 999
US – 911

In the event of a medical emergency which is not life-threatening please call:

UK – 111

Find more answers