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ZEPBOUND

ZEPBOUND ®

Coupons, Prices, Copay & Patient Assistance

Learn more about ZEPBOUND® and see what savings options may be available to you that can help bring down the cost of your medication.

Options may include Rx Advantage Card, Copay Assistance & Coupons, Canadian Pharmacy Prices or Patient Assistance Programs. Suitable for insured, underinsured or uninsured individuals. Pay as little as $0 per fill.*

Manufactured by Eli Lilly

*Applicable to Copay & Patient Assistance Programs

This content is intended for US audiences only

Drug savings programs

  • Qualified

    Rx Advantage Card

    A hand holding a dark-colored prescription savings card with various ID numbers and the label "Rx Advantage." Text below states the card is not insurance and cannot be used for Medicare or Medicaid.

    Save up to 90%

  • Available

    Canada Pharmacy

    N/A
    Manufactured by
    N/A
    Powered by
    Prescription Help Logo
  • Available

    Copay Assistance

    A hand holds a Copay Savings Card that states eligible patients with commercial insurance may pay as little as $0 per tube for Opzelura.

    Pay as little as $0

  • Unavailable

    Patient Assistance Programs

    A picture of a patient assistance application form
    Unavailable
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Jamie Winn NowPatientGreen tick
Updated on 3 May 2024

Learn more about ZEPBOUND

What is ZEPBOUND?

What is ZEPBOUND?

ZEPBOUND is the brand name for tirzepatide subcutaneous injection.

What dosages is ZEPBOUND available in?

What dosages is ZEPBOUND available in?

ZEPBOUND is available as 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen.

What is ZEPBOUND used for?

What is ZEPBOUND used for?

ZEPBOUND is a GLP-1 and GIP receptor agonist that is used for long-term weight management (with diet and exercise) in adults with:

  • Body mass index (BMI) of 30 kg/m2 or more
  • Body mass index (BMI) of 27 kg/m2 or more and have at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, obstructive sleep apnea)
How does ZEPBOUND work?

How does ZEPBOUND work?

ZEPBOUND is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It works by acting like GLP-1 and GIP, two hormones that your gut releases into the body. These hormones are thought to play a role in controlling your appetite (how hungry you feel) and therefore how much food you’re eating. By making you feel more full and less hungry, it can help you lose weight.

How do I take ZEPBOUND?

How do I take ZEPBOUND?

The typical starting dose of ZEPBOUND is 2.5 mg injected under the skin once a week. After 4 weeks, your provider will raise your dose to 5 mg once a week. The recommended maintenance dose is 5 mg, 10 mg, or 15 mg once a week, depending on how you respond to the medication.

Is it safe for me to take ZEPBOUND?

Is it safe for me to take ZEPBOUND?

ZEPBOUND is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2
  • Known serious hypersensitivity to tirzepatide or any of the excipients in ZEPBOUND
ZEPBOUND Common Side Effects

ZEPBOUND Common Side Effects

Common side effects of ZEPBOUND:

  • Nausea
  • Diarrhea
  • Constipation
  • Vomiting
  • Stomach pain
  • Indigestion
ZEPBOUND Serious Side Effects

ZEPBOUND Serious Side Effects

Serious side effects are rare with ZEPBOUND. Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reaction: hives; trouble breathing; swelling of your lips, tongue, throat, or face
  • Dangerously low blood sugar: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion
  • Kidney damage: nausea, vomiting, trouble urinating, muscle cramps, feeling confused, swelling in the ankles or feet, trouble breathing
  • Inflammation of the pancreas: nausea, vomiting, stomach pain
  • Suicidal thoughts and behavior
Effects of other drugs, drug classes and over-the-counter products on ZEPBOUND

Effects of other drugs, drug classes and over-the-counter products on ZEPBOUND

The following medications may interact with ZEPBOUND:

  • ZEPBOUND delays gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications
Who makes ZEPBOUND?

Who makes ZEPBOUND?

Eli Lilly

Is ZEPBOUND safe in pregnancy?

Is ZEPBOUND safe in pregnancy?

Weight loss offers no benefit to a pregnant patient and may cause fetal harm. Weight loss is not recommended during pregnancy and you should discontinue ZEPBOUND when a pregnancy is recognized. There will be a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ZEPBOUND (tirzepatide) during pregnancy. Pregnant patients exposed to ZEPBOUND and healthcare providers are encouraged to contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).

pill

What to do if you missed your ZEPBOUND ® dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects

What can I do if I am commercially insured but cannot afford my ZEPBOUND ®?

If you are commercially insured and you cannot afford your ZEPBOUND® copay or co-insurance you have four options:

Option

Savings Information

Copay Assistance Program

Check at the top of the page to see if there is a ZEPBOUND® Copay Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZEPBOUND® for as little as $0 per fill.

Patient Assistance Program

Check at the top of the page to see if there is a ZEPBOUND® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZEPBOUND® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card which removes the constraints of insurance and the cost can be typically lower than your plan copay or co-insurance. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

Medicaid

If the above options are not feasible then you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

What can I do if I am uninsured and cannot afford my ZEPBOUND ®?

If you are uninsured and you cannot afford your ZEPBOUND®, then you have three options:

Option

Savings Information

Patient Assistance Program

Check at the top of the page to see if there is a ZEPBOUND® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZEPBOUND® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card at a local pharmacy and obtain prices that are typically 80% of standard retail prices.

Medicaid

If the above options are not feasible then you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

What can I do if I am insured with Medicare and cannot afford my ZEPBOUND ®?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have four options:

Option

Savings Information

Patient Assistance Program

Check at the top of the page to see if there is a ZEPBOUND® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZEPBOUND® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card which removes the constraints of insurance and the cost can be typically lower than your plan copay or co-insurance. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

Low Income Subsidy

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

Medicaid

The final option is to check ‘dual eligibility’ to Medicaid in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does ZEPBOUND ® cost without insurance?

Our website gives savings options to customers who wish to purchase ZEPBOUND®, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for ZEPBOUND ® when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for ZEPBOUND® using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket ZEPBOUND® cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket ZEPBOUND® cash price you pay can be typically cheaper than your plan copay.

Where can I use the Rx Advantage Card?

You can use the Rx Advantage Card at the following pharmacies:

  • Kroger Pharmacy
  • CVS Pharmacy
  • Walgreens Pharmacy
  • RiteAid Pharmacy
  • Walmart Pharmacy
  • Costco Pharmacy

How do I check prices for ZEPBOUND ® and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your ZEPBOUND® Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a ZEPBOUND ® co-pay program?

You can check the top of the page to see if there is an option for a ZEPBOUND® co-pay card. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

What are the eligibility requirements for a ZEPBOUND ® co-pay card and how much do I have to pay?

Eligibility requirements vary between pharmaceutical companies. However, they almost all require you to be commercially insured. If you qualify there is no cost to you. It is a FREE program.

Can I enroll in the ZEPBOUND ® co-pay program if I have state, federal, or other government insurance?

Most likely, no. The copay card program is primarily designed for commercially or privately insured individuals. However, if you are finding it difficult to afford your medication, then there are other forms of assistance. For example, you can apply for LIS (Low Income Subsidy) or extra help is available online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778). As well, you can look at state assistance programs like Medicaid.

Can I enroll in the ZEPBOUND ® co-pay program if I have no insurance?

Most likely No. However, many pharmaceutical companies offer fully funded free programs for uninsured persons. These programs are called Patient Assistance Programs (PAP) and NowPatient provides a useful resource to check program availability and eligibility.

How can I check if I am eligible for the ZEPBOUND ® co-pay program?

If a ZEPBOUND® co-pay card exists, you will see it as a savings option at the top of the page. You can select the option and it will direct you to an eligibility checker. If you qualify you will be prompted to create an account with NowPatient, from where you will be able to access the instructions on how to enroll.

How do I use the ZEPBOUND ® co-pay card?

Once you are enrolled into the program you will be able to download the card. When you next fill your Rx, simply present the co-pay card to the pharmacist. The Pharmacist will use the card to process and submit your claim. You will then be provided with your discount. The program cost is covered by the pharmaceutical company.

Is there a ZEPBOUND ® Patient Assistance Program (PAP)?

You can check the top of the page to see if there is an option for a ZEPBOUND patient assistance program. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What are the eligibility requirements for a ZEPBOUND ® PAP and how much do I have to pay?

Eligibility requirements vary between pharmaceutical companies. However, they almost all require you to be uninsured, underinsured with no drug coverage, or insured but unable to afford your co-pay or co-insurance contribution. If you qualify there is no cost to you. It is a FREE program funded by the pharmaceutical company.

Can I enroll in a ZEPBOUND ® PAP if I have state, federal, or other government insurance?

It is possible. Some programs do not allow any insured individuals to apply, however, some programs do have exceptions. If you find that you do not qualify and are finding it difficult to afford your medication, then there are other forms of assistance. For example, you can apply for LIS (Low Income Subsidy) or extra help is available online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778). As well, you can look at state assistance programs like Medicaid.

Can I enroll in a ZEPBOUND ® PAP if I have no insurance?

Yes. Most programs are open to individuals who are uninsured and meet income eligibility criteria.

How can I check if I am eligible for the ZEPBOUND ® PAP?

If a ZEPBOUND® patient assistance program exists, you will see it as a savings option at the top of the page. You can select the option and it will direct you to an eligibility checker. If you qualify you will be prompted to create an account with NowPatient, from where you will be able to access the instructions on how to enroll.

How do I use the ZEPBOUND ® PAP to obtain my medication?

Once you are enrolled in the program you will be advised by the pharmaceutical company how they will make supplies to you. In most cases, they will ship the medication through their nominated mail-order pharmacy, directly to you. However, depending on the nature of the medication, the pharmaceutical company may opt to provide you with a pharmacy card (which you can redeem against your medication for FREE at your nearby pharmacy) or ship the medication directly to your healthcare provider (HCP).

Refills are usually handled by the pharmaceutical company.

I am insured but I do not qualify for patient assistance or copay assistance for ZEPBOUND ®. Is there any other form of assistance that can help with the costs of my existing copays or co-insurance?

There are a number of resources available such as charitable foundations that may be able to provide assistance for your ZEPBOUND®:

Patient Access Network Foundation (PAN) assistance for ZEPBOUND®

If you are having trouble paying for your ZEPBOUND® medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZEPBOUND® you will need to meet one or all of the following criteria:

  • Your income is below 400% of the federal poverty level
  • ZEPBOUND® is prescribed for an approved FDA indication
  • You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
  • You have Medicare insurance coverage that covers ZEPBOUND®
  • If ZEPBOUND® is listed on PAN's list of covered medications

You can check the Patient Access Network Foundation Website for more information.

HealthWell Foundation Copay Program for ZEPBOUND®

If you are having trouble paying for your ZEPBOUND® medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZEPBOUND® you will need to meet the following criteria:

  • You live in and are being treated in the United States
  • You are insured and your plan covers ZEPBOUND®
  • If ZEPBOUND® is listed on the HealthWell Foundation's list of covered medications

You can check the HealthWell Foundation Website for more information.

Patient Advocate Foundation Co-Pay Relief Program for ZEPBOUND®

Patient Advocate Foundation's Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZEPBOUND® treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZEPBOUND® you will need to meet the following criteria:

  • You must be currently insured and have coverage for ZEPBOUND®
  • You must have a confirmed diagnosis and treatment plan
  • You must reside and receive treatment in the United States
  • Your Income must fall at or below 3000r 4000f the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
  • Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.

Can I buy my ZEPBOUND ® from Canada?

Americans pay at least twice as much (in fact 218%) on prescription medications than individuals in other countries, like Canada. The reason why Canada drugs are cheaper is that Canada regulates its prescription medication drug prices (the Patented Medicines Prices Review Board) meaning that consumers pay less for their ZEPBOUND®. This prevents pharmaceutical patentees from charging excessive prices.

As well, many Canadian drugs are likely produced by exactly the same companies in the same factories, as US prescription drugs.

We have partnered with Prescription Help in Canada that carries thousands of branded and generic medications. If there is an option for ZEPBOUND® from Canada, then we will provide this as an Rx savings option to you.

Is it safe for me to buy my ZEPBOUND ® from Prescription Help, Canada?

If you purchase ZEPBOUND® from Canadian Prescription Help, then there is little reason to worry about safety since it is likely that the drugs will be the same ones you would get from your American drugstore, and would have undergone the same rigorous testing as the American counterparts. Canada drugs are regulated for safety, efficacy and quality by Health Canada, which is the Canadian equivalent of the Food and Drug Administration (FDA). If you are unsure, you can discuss this option with your physician, especially if you find it difficult affording your medications and may therefore risk not being treated.

Rest assured, NowPatient has done thorough due diligence on Prescription Help, to ensure that the service is adequately licensed, regulated and safe.

We have checked and verified that Prescription Help:

  • Is a licensed pharmacy in Canada.
  • Will only fill your ZEPBOUND® if you have a valid prescription.
  • Has a licensed pharmacist on staff to answer your questions.
  • Does not send medicine that looks different than what you receive at your usual drug store, nor does it arrive in packaging that is damaged, in a foreign language, has no expiration date, or is expired.
  • Does not charge you for products that you never ordered or received.
  • Provides clear written protections for your personal and financial information, including credit card numbers.
  • Maintains the highest standards of data security and compliance.
  • Does not sell your information to other websites.
  • Does not supply controlled substances.
  • Does not supply any products on an FDA Import Alert.
  • Quantities are restricted to a maximum of 3 month's supply for international orders.
  • Publishes contact information on website for customer service.

Is ordering ZEPBOUND ® from a Canadian Pharmacy legal?

Although it is technically not legal for individuals to import prescription drugs, It is notable that U.S. government officials have stated that individuals who procure non-controlled prescription drugs from Canada or other foreign sources for up to a three-month supply for their own use are not pursued or prosecuted. There are hundreds of thousands of American patients who have used or continue to use Canadian pharmacies to procure their medications at significant discounts. Often the price of medications can be the difference between getting treated or not being treated.

How do I place an order for ZEPBOUND ® from Prescription Help, Canada?

If your medication is available from our partner Canadian Pharmacy, then we will show it as an option. You can search for the product by pack size, strength or form and then see the price for ZEPBOUND®. If you are happy with the price, you can proceed to the checkout. This will take you to the Prescription Help website, from where you can complete the process. Prescription Help is not connected to NowPatient other than as an affiliate partner which offers services that may benefit NowPatient users. It is not insurance, any payments are strictly cash and are considered out-of-pocket.

What should I do if I take too much ZEPBOUND ®?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using ZEPBOUND®. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much ZEPBOUND®. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

What are the benefits of NowPatient?

NowPatient is more than just prescriptions and online pharmacy services. When you join you get access to a range of health services for FREE making NowPatient a perfect companion for helping you lead a healthier life. Join now by either signing up for an account online or downloading the app from the App Store today.

Learn more about all the features you can start benefiting from today!

US brand name of ZEPBOUND ® and manufacturer

ZEPBOUND is the brand name of tirzepatide and is available in the US under the brand name Zepbound. It is manufactured by Eli Lilly.

 

 

Zepbound pen

Source: Eli Lilly

 

UK brand name of ZEPBOUND ®  and manufacturer

Zepbound is the brand name of tirzepatide. Zepbound is not yet licensed in the UK, however, it is understood Eli Lilly, the manufacturer, has plans to market it in the UK at some point in 2024, subject to regulatory approval.

Is ZEPBOUND ®  available in the UK on the NHS?

Zepbound is not yet licensed in the UK, therefore, Zepbound is not available on the NHS as yet.

Prescription requirement for ZEPBOUND ®

Zepbound (tirzepatide) is available in an injectable Pen format in the following strengths:

  • 2.5mg/0.5mL
  • 5mg/0.5mL
  • 7.5mg/0.5mL
  • 10mg/0.5mL
  • 12.5mg/0.5mL
  • 15mg/0.5mL

Zepbound is a prescription medicine and requires a valid prescription.

FDA approval of ZEPBOUND ®

Zepbound has received FDA approval for chronic weight management in adults with:

chronic weight management in adults with

obesity (body mass index of 30 kilograms per square meter (kg/ m2) or greater);

or overweight (body mass index of 27 kg/m2 or greater) with at least one weight-related condition (such as high blood pressure, obstructive sleep apnea, type 2 diabetes or high cholesterol) for use, in addition to a reduced calorie diet and increased physical activity.

It is not know if ZEPBOUND can be used in people who had pancreatitis.

It is not known if ZEPBOUND is safe and effective for use in children under 18 years of age.

When not to use ZEPBOUND ® ?

There are certain precautions where ZEPBOUND may not be suitable if:

  • You are allergic to tirzepatide or ingredients found in ZEPBOUND pen
  • You have problems with your pancreas or kidney
  • You have a history of diabetic retinopathy
  • You are pregnant or breastfeeding or plan to become pregnant or breastfeed
  • You or you family have had medullary thyroid carcinoma – MTC
  • You have Multiple Endocrine Neoplasia syndrome type 2 -MEN 2
  • You have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food
  • You are taking insulin or sulfonylureas
  • You take birth control pills by mouth? These may not work as well while using ZEPBOUND. Your healthcare provider may recommend another type of birth control when you start ZEPBOUND or when you increase your dose
  • You have type 1 diabetes

Active ingredient of ZEPBOUND ®  and mechanism of action

The active ingredient in ZEPBOUND is tirzepatide. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. It is the first and only unimolecular dual GIP/GLP-1 receptor agonist.

Both GIP and GLP-1 increase the production of insulin in your body.

It has proven to result in significant reductions in A1c levels and body weight. ZEPBOUND works in several ways:

  • It increases insulin production, but only when your blood sugar is rising—which makes the risk of low blood sugar minimal
  • It decreases your liver’s production of sugar
  • It slows down the speed at which your stomach empties food into your intestine. This helps manage your blood sugars after eating while also leaving you feeling full longer

Is ZEPBOUND ® as effective as WEGOVY? 

ZEPBOUND is more effective than WEGOVY (semaglutide) for weight loss. For people taking ZEPBOUND, the weight loss can reach up to 21% compared to the weight loss that you see from WEGOVY which tops out at around 15%.

 

A woman in a green shirt is wearing a green shirt.

 

Does ZEPBOUND ®  reduce cardiovascular risks?

Findings published in the American Heart Association’s journal Hypertension, involving 500 people whose blood pressure was monitored continuously showed that readings from the 24-hour period at the start of the study to the 24-hour period at the end of the 36-week trial period resulted in people’s systolic blood pressure decreasing by between 7 and 10 points, depending on the dosage of ZEPBOUND administered.

Systolic blood pressure is the reading that is a predictor of heart attacks.

Can ZEPBOUND ®  be used for weight loss?

Yes. ZEPBOUND is approved by the FDA for use in chronic weight management.

Can ZEPBOUND ®  Pen be shared?

No. You should not share your ZEPBOUND pen with others, even if the needle is changed. You may give other people a serious infection or get a serious infection from them through cross-contamination.

Is it safe to use compounded ZEPBOUND ® ?

The manufacturer has said that they do not sell ZEPBOUND or the active ingredient tirzepatide for compounding. Eli Lilly is the sole company that has FDA approval to market ZEPBOUND and it is supplied in a branded box that includes a proprietary pen along with FDA-approved prescribing information. Eli Lilly cannot validate safety or effectiveness of products claiming to contain tirzepatide. Therefore, compounded ZEPBOUND should be avoided.

Is there a shortage of ZEPBOUND ® ?

ZEPBOUND, in all strengths, is available to community pharmacies nationwide for treatment in patients with obesity.

However, while it is currently available, comments from the CEO of Eli Lilly in January 2024, suggest that the pharmaceutical company many not be able to meet market demand in 2024.

After the drug was approved in December 2023, there were 25,000 new prescriptions a week issued for ZEPBOUND.

Forms of ZEPBOUND ®

ZEPBOUND comes as a solution in a prefilled, single-dose injection pen (requires no mixing) with the following dosage strengths:

  • 2.5mg/0.5mL
  • 5mg/0.5mL
  • 7.5mg/0.5mL
  • 10mg/0.5mL
  • 12.5mg/0.5mL
  • 15mg/0.5mL

Storage requirements for ZEPBOUND ®

ZEPBOUND is temperature sensitive and should be handled as follows:

  • Store your Pen in the refrigerator between 2C to 8C
  • You may store your Pen at room temperature below 30C for up to a total of 21 days
  • Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen
  • Store your Pen in the original carton to protect your Pen from light
  • The Pen has glass parts. Handle it carefully. If you drop the Pen on a hard surface, do not use it. Use a new Pen for your injection
  • Keep your ZEPBOUND Pen and all medicines out of the sight and reach of children

Dosage of ZEPBOUND ®

ZEPBOUND is given as a weekly injection under the skin (subcutaneous). It should be administered at the same time each week, at any time of the day.

Patients are initiated with the 2.5-mg dose once weekly.

After 4 weeks on the 2.5-mg dose, the physician may increase to the 5-mg dose once weekly. The physician can continue to increase the dose by 2.5-mg increments after at least 4 weeks on the current dose. The maximum dose is 15 mg once weekly.

 

A chart displaying various blood sugar testing methods.

Source: Eli Lilly

Even though doses change, the administration frequency will always be weekly. It is important to follow the dosage instructions provided by your healthcare provider.

Missing or changing your dosing schedule of ZEPBOUND ®

If you miss a dose of ZEPBOUND, take it as soon as possible – within 4 days (96 hours) of your scheduled dosing.  If more than 4 days have passed, skip the missed dose and take your next dose on your regularly scheduled day.  DO NOT TAKE 2 doses of ZEPBOUND within 3 days (72 hours) of each other.

How long does it take for ZEPBOUND ®  to start working?

ZEPBOUND starts working immediately, but it might take several weeks before you begin to notice any weight loss.  Weight loss also depends on calorie intake and physical activity.

How do I use the ZEPBOUND ®  Pen?

After inspecting your pen, Follow these 4 steps to use your ZEPBOUND pen:

Step 1: Choose your injection site. Your healthcare provider can help you choose the injection site that is best for you. You or another person can inject the medicine in your stomach, thighs, or the back of your upper arms. Another person should give you the injection in the back of your upper arm.

Choose your Zepbound injection site.

Step 2: Pull off the base cap.

 

A diagram illustrating how to remove the cap, perfect for travelers or adventurers.

 

Step 3: Place the base flat on your skin, then unlock.

 

A sign demonstrating how to properly position and unlock a pregnancy test.

 

Step 4: Press and hold the button for up to 10 seconds. Even if you don’t feel a poke, listen for two clicks, the injection is complete. You will know your is complete when the grey plunger is visible.

Press and hold the Zepbound button for up to 10 seconds.

 

How long can I continue using ZEPBOUND ® ?

ZEPBOUND is designed to be a long-term maintenance treatment. ZEPBOUND is safe and effective when used as indicated for the management of obesity.

What are the common side effects of ZEPBOUND ® ?

  • Nausea
  • Diarrhea
  • Decreased appetite
  • Vomiting
  • Constipation
  • Indigestion
  • Stomach pain
  • Injection site reactions
  • Hair loss
  • Belching

What are the serious side effects of ZEPBOUND ® ?

  • Sudden inflammation of your pancreas (pancreatitis)
  • Severe diarrhea, nausea, or vomiting
  • Low blood sugar (hyproglycemia)
  • Serious allergic reactions
  • Possible risk of thyroid cancer

Contact your healthcare provider if you experience any serious side effects.

What can I do if I experience nausea when using ZEPBOUND ® ?

  • Consume bland, low-fat foods, like crackers, toast, rice
  • Eat smaller meals–try splitting your 3 daily meals into 4 or more smaller ones
  • Stop eating when you feel full
  • Avoid laying down after eating
  • Avoid fat or fatty foods
  • Drink ice-cold drinks

What support resources are there for ZEPBOUND ® ?

You can read more about support programs that exist for ZEPBOUND at Zepbound.Lilly

What prescription assistance is available for ZEPBOUND ® ?

Prescription drug prices can be confusing. Two people may pay different prices for the same drug, depending on their insurance situation. The list price of ZEPBOUND is $1,060.00 per fill, but the amount you pay will largely depend on your prescription drug insurance plan.

Commercially insured patients may be eligible for the ZEPBOUND Savings Card program where you can pay as little as $25 per fill.

If you are not eligible for the ZEPBOUND Savings Program, then you may have to pay close to the list price shown above, plus any additional pharmacy charges depending on where you purchase your medicine.

If you are interested in obtaining insurance, there are resources available to help you:

  • To find out if you qualify for Medicaid and for information about copayments in your state, please visit: Medicaid State Overviews
  • To learn more about private individual policies via the Insurance Marketplace, please visit: the Medical Assistance Tool

For the most accurate information, talk to your insurance provider who knows the details of your plan.

Interactions with other drugs

Ozempic may interact with certain medications, including:

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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