ZEPBOUND
Used for Type 2 Diabetes and Weight loss
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Manufactured by Eli Lilly
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ZEPBOUND key facts
What is ZEPBOUND?
ZEPBOUND is the brand name for tirzepatide subcutaneous injection.
What dosages is ZEPBOUND available in?
ZEPBOUND is available as 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen.
What is ZEPBOUND used for?
ZEPBOUND is a GLP-1 and GIP receptor agonist that is used for long-term weight management (with diet and exercise) in adults with:
- Body mass index (BMI) of 30 kg/m2 or more
- Body mass index (BMI) of 27 kg/m2 or more and have at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, obstructive sleep apnea)
How does ZEPBOUND work?
ZEPBOUND is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It works by acting like GLP-1 and GIP, two hormones that your gut releases into the body. These hormones are thought to play a role in controlling your appetite (how hungry you feel) and therefore how much food you’re eating. By making you feel more full and less hungry, it can help you lose weight.
How do I take ZEPBOUND?
The typical starting dose of ZEPBOUND is 2.5 mg injected under the skin once a week. After 4 weeks, your provider will raise your dose to 5 mg once a week. The recommended maintenance dose is 5 mg, 10 mg, or 15 mg once a week, depending on how you respond to the medication.
Is it safe for me to take ZEPBOUND?
ZEPBOUND is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2
- Known serious hypersensitivity to tirzepatide or any of the excipients in ZEPBOUND
ZEPBOUND Common Side Effects
Common side effects of ZEPBOUND:
- Nausea
- Diarrhea
- Constipation
- Vomiting
- Stomach pain
- Indigestion
ZEPBOUND Serious Side Effects
Serious side effects are rare with ZEPBOUND. Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: hives; trouble breathing; swelling of your lips, tongue, throat, or face
- Dangerously low blood sugar: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion
- Kidney damage: nausea, vomiting, trouble urinating, muscle cramps, feeling confused, swelling in the ankles or feet, trouble breathing
- Inflammation of the pancreas: nausea, vomiting, stomach pain
- Suicidal thoughts and behavior
Effects of other drugs, drug classes and over-the-counter products on ZEPBOUND
The following medications may interact with ZEPBOUND:
- ZEPBOUND delays gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications
Who makes ZEPBOUND?
Eli Lilly
Is ZEPBOUND safe in pregnancy?
Weight loss offers no benefit to a pregnant patient and may cause fetal harm. Weight loss is not recommended during pregnancy and you should discontinue ZEPBOUND when a pregnancy is recognized. There will be a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ZEPBOUND (tirzepatide) during pregnancy. Pregnant patients exposed to ZEPBOUND and healthcare providers are encouraged to contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ZEPBOUND prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ZEPBOUND prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ZEPBOUND savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ZEPBOUND savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ZEPBOUND | Canadian Prescription Savings* for ZEPBOUND | ZEPBOUND Drug Coupon* | ZEPBOUND Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ZEPBOUND?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ZEPBOUND | Canadian Prescription Savings* for ZEPBOUND | ZEPBOUND Drug Coupon* | ZEPBOUND Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ZEPBOUND savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ZEPBOUND drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ZEPBOUND, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ZEPBOUND prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ZEPBOUND is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ZEPBOUND for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ZEPBOUND prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ZEPBOUND prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ZEPBOUND
If you are having trouble paying for your ZEPBOUND medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZEPBOUND you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ZEPBOUND is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ZEPBOUND
- If ZEPBOUND is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ZEPBOUND
If you are having trouble paying for your ZEPBOUND medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZEPBOUND you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ZEPBOUND
- If ZEPBOUND is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ZEPBOUND
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZEPBOUND treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZEPBOUND you will need to meet the following criteria:
- You must be currently insured and have coverage for ZEPBOUND
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
US brand name of ZEPBOUND and manufacturer
ZEPBOUND is the brand name of tirzepatide and is available in the US under the brand name Zepbound. It is manufactured by Eli Lilly.
Source: Eli Lilly
UK brand name of ZEPBOUND and manufacturer
Zepbound is the brand name of tirzepatide. Zepbound is not yet licensed in the UK, however, it is understood Eli Lilly, the manufacturer, has plans to market it in the UK at some point in 2024, subject to regulatory approval.
Is ZEPBOUND available in the UK on the NHS?
Zepbound is not yet licensed in the UK, therefore, Zepbound is not available on the NHS as yet.
Prescription requirement for ZEPBOUND
Zepbound (tirzepatide) is available in an injectable Pen format in the following strengths:
- 2.5mg/0.5mL
- 5mg/0.5mL
- 7.5mg/0.5mL
- 10mg/0.5mL
- 12.5mg/0.5mL
- 15mg/0.5mL
Zepbound is a prescription medicine and requires a valid prescription.
FDA approval of ZEPBOUND
Zepbound has received FDA approval for chronic weight management in adults with:
chronic weight management in adults with
obesity (body mass index of 30 kilograms per square meter (kg/ m2) or greater);
or overweight (body mass index of 27 kg/m2 or greater) with at least one weight-related condition (such as high blood pressure, obstructive sleep apnea, type 2 diabetes or high cholesterol) for use, in addition to a reduced calorie diet and increased physical activity.
It is not know if ZEPBOUND can be used in people who had pancreatitis.
It is not known if ZEPBOUND is safe and effective for use in children under 18 years of age.
When not to use ZEPBOUND ?
There are certain precautions where ZEPBOUND may not be suitable if:
- You are allergic to tirzepatide or ingredients found in ZEPBOUND pen
- You have problems with your pancreas or kidney
- You have a history of diabetic retinopathy
- You are pregnant or breastfeeding or plan to become pregnant or breastfeed
- You or you family have had medullary thyroid carcinoma – MTC
- You have Multiple Endocrine Neoplasia syndrome type 2 -MEN 2
- You have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food
- You are taking insulin or sulfonylureas
- You take birth control pills by mouth? These may not work as well while using ZEPBOUND. Your healthcare provider may recommend another type of birth control when you start ZEPBOUND or when you increase your dose
- You have type 1 diabetes
Active ingredient of ZEPBOUND and mechanism of action
The active ingredient in ZEPBOUND is tirzepatide. Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist. It is the first and only unimolecular dual GIP/GLP-1 receptor agonist.
Both GIP and GLP-1 increase the production of insulin in your body.
It has proven to result in significant reductions in A1c levels and body weight. ZEPBOUND works in several ways:
- It increases insulin production, but only when your blood sugar is rising—which makes the risk of low blood sugar minimal
- It decreases your liver’s production of sugar
- It slows down the speed at which your stomach empties food into your intestine. This helps manage your blood sugars after eating while also leaving you feeling full longer
Is ZEPBOUND as effective as WEGOVY?
ZEPBOUND is more effective than WEGOVY (semaglutide) for weight loss. For people taking ZEPBOUND, the weight loss can reach up to 21% compared to the weight loss that you see from WEGOVY which tops out at around 15%.
Does ZEPBOUND reduce cardiovascular risks?
Findings published in the American Heart Association’s journal Hypertension, involving 500 people whose blood pressure was monitored continuously showed that readings from the 24-hour period at the start of the study to the 24-hour period at the end of the 36-week trial period resulted in people’s systolic blood pressure decreasing by between 7 and 10 points, depending on the dosage of ZEPBOUND administered.
Systolic blood pressure is the reading that is a predictor of heart attacks.
Can ZEPBOUND be used for weight loss?
Yes. ZEPBOUND is approved by the FDA for use in chronic weight management.
Can ZEPBOUND Pen be shared?
No. You should not share your ZEPBOUND pen with others, even if the needle is changed. You may give other people a serious infection or get a serious infection from them through cross-contamination.
Is it safe to use compounded ZEPBOUND ?
The manufacturer has said that they do not sell ZEPBOUND or the active ingredient tirzepatide for compounding. Eli Lilly is the sole company that has FDA approval to market ZEPBOUND and it is supplied in a branded box that includes a proprietary pen along with FDA-approved prescribing information. Eli Lilly cannot validate safety or effectiveness of products claiming to contain tirzepatide. Therefore, compounded ZEPBOUND should be avoided.
Is there a shortage of ZEPBOUND ?
ZEPBOUND, in all strengths, is available to community pharmacies nationwide for treatment in patients with obesity.
However, while it is currently available, comments from the CEO of Eli Lilly in January 2024, suggest that the pharmaceutical company many not be able to meet market demand in 2024.
After the drug was approved in December 2023, there were 25,000 new prescriptions a week issued for ZEPBOUND.
Forms of ZEPBOUND
ZEPBOUND comes as a solution in a prefilled, single-dose injection pen (requires no mixing) with the following dosage strengths:
- 2.5mg/0.5mL
- 5mg/0.5mL
- 7.5mg/0.5mL
- 10mg/0.5mL
- 12.5mg/0.5mL
- 15mg/0.5mL
Storage requirements for ZEPBOUND
ZEPBOUND is temperature sensitive and should be handled as follows:
- Store your Pen in the refrigerator between 2C to 8C
- You may store your Pen at room temperature below 30C for up to a total of 21 days
- Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen
- Store your Pen in the original carton to protect your Pen from light
- The Pen has glass parts. Handle it carefully. If you drop the Pen on a hard surface, do not use it. Use a new Pen for your injection
- Keep your ZEPBOUND Pen and all medicines out of the sight and reach of children
Dosage of ZEPBOUND
ZEPBOUND is given as a weekly injection under the skin (subcutaneous). It should be administered at the same time each week, at any time of the day.
Patients are initiated with the 2.5-mg dose once weekly.
After 4 weeks on the 2.5-mg dose, the physician may increase to the 5-mg dose once weekly. The physician can continue to increase the dose by 2.5-mg increments after at least 4 weeks on the current dose. The maximum dose is 15 mg once weekly.
Source: Eli Lilly
Even though doses change, the administration frequency will always be weekly. It is important to follow the dosage instructions provided by your healthcare provider.
Missing or changing your dosing schedule of ZEPBOUND
If you miss a dose of ZEPBOUND, take it as soon as possible – within 4 days (96 hours) of your scheduled dosing. If more than 4 days have passed, skip the missed dose and take your next dose on your regularly scheduled day. DO NOT TAKE 2 doses of ZEPBOUND within 3 days (72 hours) of each other.
How long does it take for ZEPBOUND to start working?
ZEPBOUND starts working immediately, but it might take several weeks before you begin to notice any weight loss. Weight loss also depends on calorie intake and physical activity.
How do I use the ZEPBOUND Pen?
After inspecting your pen, Follow these 4 steps to use your ZEPBOUND pen:
Step 1: Choose your injection site. Your healthcare provider can help you choose the injection site that is best for you. You or another person can inject the medicine in your stomach, thighs, or the back of your upper arms. Another person should give you the injection in the back of your upper arm.
Step 2: Pull off the base cap.
Step 3: Place the base flat on your skin, then unlock.
Step 4: Press and hold the button for up to 10 seconds. Even if you don’t feel a poke, listen for two clicks, the injection is complete. You will know your is complete when the grey plunger is visible.
How long can I continue using ZEPBOUND ?
ZEPBOUND is designed to be a long-term maintenance treatment. ZEPBOUND is safe and effective when used as indicated for the management of obesity.
What are the common side effects of ZEPBOUND ?
- Nausea
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
- Indigestion
- Stomach pain
- Injection site reactions
- Hair loss
- Belching
What are the serious side effects of ZEPBOUND ?
- Sudden inflammation of your pancreas (pancreatitis)
- Severe diarrhea, nausea, or vomiting
- Low blood sugar (hyproglycemia)
- Serious allergic reactions
- Possible risk of thyroid cancer
Contact your healthcare provider if you experience any serious side effects.
What can I do if I experience nausea when using ZEPBOUND ?
- Consume bland, low-fat foods, like crackers, toast, rice
- Eat smaller meals–try splitting your 3 daily meals into 4 or more smaller ones
- Stop eating when you feel full
- Avoid laying down after eating
- Avoid fat or fatty foods
- Drink ice-cold drinks
What support resources are there for ZEPBOUND ?
You can read more about support programs that exist for ZEPBOUND at Zepbound.Lilly
What prescription assistance is available for ZEPBOUND ?
Prescription drug prices can be confusing. Two people may pay different prices for the same drug, depending on their insurance situation. The list price of ZEPBOUND is $1,060.00 per fill, but the amount you pay will largely depend on your prescription drug insurance plan.
Commercially insured patients may be eligible for the ZEPBOUND Savings Card program where you can pay as little as $25 per fill.
If you are not eligible for the ZEPBOUND Savings Program, then you may have to pay close to the list price shown above, plus any additional pharmacy charges depending on where you purchase your medicine.
If you are interested in obtaining insurance, there are resources available to help you:
- To find out if you qualify for Medicaid and for information about copayments in your state, please visit: Medicaid State Overviews
- To learn more about private individual policies via the Insurance Marketplace, please visit: the Medical Assistance Tool
For the most accurate information, talk to your insurance provider who knows the details of your plan.
Interactions with other drugs
Ozempic may interact with certain medications, including:
- Insulin (Humalog, Tresiba, Lantus, Basaglar, Fiasp)
- Sulfonylureas (Amayrl, glyburide, glipizide)
- Meglitinides (repaglinide, nateglinide)
- Birth control pills (drospirenone/estetrol, ethinyl estradiol/norethindrone, ethinyl estradiol/norgestimate)
- Ibuprofen
- Simvastatin
- Atorvastatin (Lipitor)
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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