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Zepbound is the brand name for tirzepatide subcutaneous injection.

Zepbound is available as 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen.

Zepbound is a GLP-1 and GIP receptor agonist that is used for long-term weight management (with diet and exercise) in adults with:

• Body mass index (BMI) of 30 kg/m2 or more
• Body mass index (BMI) of 27 kg/m2 or more and have at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, obstructive sleep apnea)

Zepbound is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. It works by acting like GLP-1 and GIP, two hormones that your gut releases into the body. These hormones are thought to play a role in controlling your appetite (how hungry you feel) and therefore how much food you’re eating. By making you feel more full and less hungry, it can help you lose weight.

The typical starting dose of Zepbound is 2.5 mg injected under the skin once a week. After 4 weeks, your provider will raise your dose to 5 mg once a week. The recommended maintenance dose is 5 mg, 10 mg, or 15 mg once a week, depending on how you respond to the medication.

Zepbound is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2
• Known serious hypersensitivity to tirzepatide or any of the excipients in Zepbound

Common side effects of Zepbound:

• Nausea
• Diarrhea
• Constipation
• Vomiting
• Stomach pain
• Indigestion

Serious side effects are rare with Zepbound. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: hives; trouble breathing; swelling of your lips, tongue, throat, or face
• Dangerously low blood sugar: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion
• Kidney damage: nausea, vomiting, trouble urinating, muscle cramps, feeling confused, swelling in the ankles or feet, trouble breathing
• Inflammation of the pancreas: nausea, vomiting, stomach pain
• Suicidal thoughts and behavior

The following medications may interact with Zepbound:

• Zepbound delays gastric emptying and has the potential to impact the absorption of concomitantly administered oral medications

Eli Lilly and Company

Weight loss offers no benefit to a pregnant patient and may cause fetal harm. Weight loss is not recommended during pregnancy and you should discontinue Zepbound when a pregnancy is recognized. There will be a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Zepbound (tirzepatide) during pregnancy. Pregnant patients exposed to Zepbound and healthcare providers are encouraged to contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979).

• Tirzepatide