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Is retatrutide available yet?

Is retatrutide available yet?

Navin Khosla NowPatientGreen tick
Created on 27 Aug 2024
Updated on 27 Dec 2024

In the ever-evolving landscape of weight management solutions, the pharmaceutical industry has been brimming with promising developments surrounding a new experimental drug called retatrutide. Manufactured by the renowned pharmaceutical giant Eli Lilly, this new drug has gained significant attention for its potential to deliver unprecedented weight loss results, outperforming even the current market-leading medications.

Retatrutide’s weight loss potential

The standout feature of retatrutide is its ability to achieve high levels of weight loss in clinical trials. According to the findings published in the New England Journal of Medicine and The Lancet, participants in mid-stage studies who received the highest dose of retatrutide experienced an average weight loss of 24% of their body weight, or approximately 58 pounds, over 48 weeks.

These results are particularly noteworthy when compared to other weight loss medications currently available. Novo Nordisk’s semaglutide, the active ingredient in the popular drugs Ozempic and Wegovy, has been shown to reduce body weight by around 15%, or about 34 pounds, after 68 weeks. Lilly’s weight loss drug, tirzepatide (marketed as Mounjaro), demonstrated an average body weight reduction of 22.5%, or approximately 52 pounds, after 72 weeks.

The speed at which retatrutide produces weight loss is also impressive, with participants experiencing significant reductions in as little as 24 weeks. This rapid weight loss sets retatrutide apart from its competitors, potentially providing a more life-changing experience for individuals struggling with obesity or being overweight.

Retatrutide’s unique mechanism of action

What sets retatrutide apart from other weight loss drugs is its unique mechanism of action, which targets not one, but three distinct hormones in regulating hunger, metabolism, and glucose control.

Unlike Ozempic and Wegovy, which are solely glucagon-like peptide-1 (GLP-1) receptor agonists, or Mounjaro, which combines GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonism, retatrutide takes a more comprehensive approach. In addition to mimicking GLP-1 and GIP, retatrutide also targets the glucagon receptor, a crucial hormone in glucose and lipid metabolism, further promoting weight loss.

This “triple G” effect, as it has been dubbed, is believed to be the driving force behind retatrutide’s superior weight loss results compared to other medications in its class. By simultaneously activating these three key hormonal pathways, retatrutide appears to harness the body’s natural mechanisms that regulate food intake, energy expenditure, and metabolic processes more effectively.

The remarkable weight loss outcomes observed with retatrutide have the potential to significantly impact the treatment of obesity and its associated risk factors. Obesity, a growing global health concern, affects over 42% of Americans, according to the National Institute of Diabetes and Digestive and Kidney Diseases.

Retatrutide has demonstrated positive effects on glycemic control in individuals with type 2 diabetes. In a separate study published in The Lancet, participants with type 2 diabetes who received retatrutide experienced an average weight loss of 17% of their body weight in just nine months, a remarkable achievement given the typically more challenging weight loss path for this patient population.

The ability of retatrutide to simultaneously address both obesity and its associated metabolic complications, such as type 2 diabetes, could have far-reaching implications. By improving glycemic control and helping substantial weight loss, retatrutide may help reduce the risk of cardiovascular disease, obstructive sleep apnea, and other obesity-related risk factors, ultimately leading to improved overall health outcomes for individuals struggling with these conditions.

Timeline for retatrutide

Despite the promising results from the mid-stage clinical trials, retatrutide still has a long way to go before it becomes available to the public. The drug is currently in the process of entering larger, phase 3 clinical trials, which are expected to be completed by late 2025, according to clinicaltrials.gov.

Once the phase 3 trials are successfully concluded, Eli Lilly will need to submit the data to the U.S. Food and Drug Administration (FDA) for review and approval. This rigorous regulatory process can take several additional years, with experts estimating that retatrutide may not reach the market until 2028 or later.

The extended timeline is not uncommon for novel weight loss medications, as the FDA scrutinises these therapies closely to ensure their safety and efficacy.

The enthusiasm surrounding retatrutide’s potential has fueled optimism among healthcare professionals, who believe that this drug could be a game-changer in the fight against obesity and its associated complications.

Conclusion

As the pharmaceutical industry continues to push the boundaries of what is possible in weight loss management, the anticipation surrounding retatrutide and its potential to become a game-changer in the field remains palpable. While the path to market approval may be lengthy, the promise of this remarkable drug offers hope to millions of individuals seeking a more transformative solution to the challenges of obesity.

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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