NowPatient Blog
The link between rybelsus meds and reducing body weight

The link between rybelsus meds and reducing body weight

Have you been struggling with maintaining a healthy weight? Are you tired of trying different diets and workouts with little to no success? Look no further than the brand name prescription drug Rybelsus, manufactured by Novo Nordisk. Rybelsus is a popular diabetes medication for type 2 diabetes used to control blood sugar, but it has also been found to aid in weight loss. In this blog post, we will explore how this medication can help in reducing body weight and who can benefit from it. We’ll also discuss the potential side effects to help you make an informed decision about whether Rybelsus is right for you.

What is Rybelsus Medication?

Rybelsus is a prescription medication containing the active ingredient semaglutide. It is an oral tablet used to treat type 2 diabetes mellitus and also helps to reduce the risk of severe cardiovascular events. It is not used to treat type 1 diabetes.

Rybelsus belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists or GLP-1 inhibitors. It is useful to know Ozempic is the higher dose version of Rybelsus in an injectable form for diabetes.

It works by lowering blood glucose levels and reducing A1C levels, which measures average blood sugar levels over the past three months. It also helps to reduce body weight in individuals with obesity or those overweight before treatment begins.

To achieve the best results, Rybelsus should be taken once daily before breakfast on an empty stomach, with no food or liquid for at least 30 minutes after taking it. The dosage may vary based on individual needs and medical history. However, it is crucial to follow your doctor’s instructions when taking this medication, for optimal health benefits.

Mechanism of action

Rybelsus medication works by targeting various biological pathways to help patients lose weight. The mechanism of action includes:

  • Stimulating insulin production: Rybelsus increases the amount of insulin released from the pancreas after a meal, which helps to lower blood glucose levels and reduce appetite
  • Reducing appetite through the GLP-1 receptor pathway: Rybelsus activates receptors in the gut that signal fullness and satiety, leading to reduced feelings of hunger
  • Slowing down digestion to increase feelings of fullness: Rybelsus slows down gastric emptying, which can prolong feelings of fullness after a meal

These effects work together to help patients control their blood glucose levels and reduce body weight. By targeting multiple mechanisms, Rybelsus can provide an effective treatment option for those struggling with obesity or type 2 diabetes.


When taking Rybelsus medication to manage blood glucose levels, it’s important to follow the prescribed dosage. Here are some key dosing guidelines to keep in mind:

  • Starting with a low dose and gradually increasing: Your healthcare provider will likely start you on a lower dose of Rybelsus and increase it over time as needed
  • Taking it once a day before the first meal: To get the most benefit from Rybelsus, take it at least 30 minutes before your first meal of the day
  • Not exceeding the recommended maximum daily dosage: Taking more than the prescribed amount won’t improve its effectiveness and may increase your risk for side effects

Remember that while controlling blood glucose levels is important for overall health, weight management can also play an important role in managing conditions such as type 2 diabetes. Talk to your healthcare provider about how Rybelsus may help you achieve both goals together.

Can Rybelsus be used for weight loss in non-diabetics?

While Rybelsus is not yet approved as a weight loss drug for those without diabetes, Wegovy is a GLP-1 receptor agonist that has been granted the green light as a weight loss medication. This medication was developed after clinical trials showed promising results for the role semaglutide plays in weight loss.

If your prescribing doctor determines it is safe and medically appropriate, it is possible that Rybelesus can be prescribed off-label for weight management, if deemed medically appropriate. It is prescribed off-label for those with a body mass index (BMI) of 30 and over with at least one weight-related issue, such as high blood pressure. It must be taken alongside a healthy diet and exercise regime to see the full benefits.

How Does Rybelsus Medication Help in Reducing Body Weight?

Rybelsus medication helps in reducing body weight by reducing hunger pangs and caloric intake, while increasing insulin sensitivity. With its active ingredient, semaglutide, Rybelsus works to mimic the effects of a hormone called Glucagon-like peptide-1 (GLP-1) that is naturally found in the body. This helps to increase feelings of fullness after eating and reduces cravings for high-calorie foods. Rybelsus medication reduces body weight by reducing hunger pangs and increasing insulin sensitivity.

By reducing caloric intake and promoting healthy food choices, Rybelsus can help patients achieve their weight loss goals. Additionally, improved insulin sensitivity can lead to better blood sugar control, which may also contribute to weight loss efforts. It’s important to note that Rybelsus should always be used as part of a comprehensive weight management plan that includes diet and exercise modifications, under the guidance of a healthcare professional.

Reduces Hunger Pangs

If you’re struggling with hunger pangs and find it difficult to stick to your dietary goals, Rybelsus medication may offer a solution. One of the ways it works is by activating GLP-1 receptors that suppress appetite, reducing the urge to snack or overeat. Additionally, Rybelsus helps regulate the hypothalamus to reduce hunger signals sent from this part of your brain. With these two mechanisms at work, you’ll be able to better manage your cravings and make healthy choices about what foods you consume.

Another benefit of taking Rybelsus is its positive effect on digestive function and satiety. By improving how efficiently nutrients are absorbed into the body and how full you feel after meals, this medication can help prevent overeating caused by poor digestion or lack of satisfaction from food. All in all, if hunger pangs have been sabotaging your weight loss efforts thus far, adding Rybelsus to your treatment plan may be just what you need for success!

Reduces Caloric Intake

Decrease in food cravings and snacking behaviours are common struggles faced by individuals trying to lose weight. However, the use of Rybelsus medication has been linked to reducing these habits, leading to a decrease in overall caloric intake. Additionally, increased feelings of fullness have been reported, resulting in a reduction in meal portion sizes.

Improved adherence to dietary plans is another benefit of using Rybelsus medication for weight loss. Patients often struggle with following strict dietary plans due to cravings or lack of satiety after meals. However, with reduced hunger pangs and improved feelings of fullness experienced while taking Rybelsus medication, patients may find it easier to stick to their prescribed diet plan for effective weight loss results.

Increases Insulin Sensitivity

Promoting glucose uptake by cells for energy, instead of storing it as fat is one way that Rybelsus medication can increase insulin sensitivity. This means that the body can utilise glucose more efficiently, which in turn helps to regulate blood sugar levels and reduce the risk of type 2 diabetes.

Another benefit of enhanced insulin secretion by pancreatic beta-cells due to Rybelsus medication is improved glycemic control. With better regulation of blood glucose levels through increased insulin sensitivity and secretion, patients are less likely to experience spikes in their blood sugar after meals or during periods of stress. This can lead to greater feelings of stability and comfort throughout the day, making it easier to maintain a healthy diet and exercise routine for weight loss purposes.

Who Can Take Rybelsus Medication for Reducing Body Weight?

If you are an individual with Type 2 Diabetes or have a BMI above 27, Rybelsus medication may be a suitable option for reducing body weight. However, it is important to consult with your healthcare provider before starting any new medication. They can help determine if Rybelsus is right for you and monitor any potential side effects or interactions with other medications you may be taking. Remember that lifestyle changes such as exercise and a healthy diet also play an important role in achieving weight loss goals.

Individuals with Type 2 Diabetes

For individuals with Type 2 diabetes, Rybelsus medication can aid in reducing body weight. The medication works by targeting the GLP-1 hormone, which helps to regulate blood sugar levels and decrease appetite. Here are some important points to note about using Rybelsus while managing diabetes:

  • Recommended dosage and frequency: Typically, patients start on a 3 mg dose once daily for 30 days before increasing to the standard dose of 7 mg once daily
  • Potential side effects: While taking Rybelsus medication may aid in weight loss for diabetic patients, there are potential side effects such as nausea, vomiting or diarrhoea that should be discussed with your healthcare provider

It’s important to consult with your doctor before starting any new medications for weight management when living with diabetes. Your healthcare team will evaluate whether Rybelsus is right for you based on factors like other medications being taken and overall health status.

Individuals with BMI Above 27

For individuals with a BMI above 27, Rybelsus medication can be an effective aid in achieving weight loss goals. However, it is important to complement the use of medication with lifestyle changes such as regular exercise and a healthy diet. Consulting a healthcare provider before starting on a course of Rybelsus medication is also crucial for personalized treatment plans and monitoring any potential side effects. Remember that weight loss is a journey that requires commitment and patience, but incorporating Rybelsus into your routine may help you reach your goals more effectively.

What Are the Side Effects of Rybelsus Medication?

Like any medication, there are potential side effects that patients should be aware of. Nausea, vomiting and constipation are common side effects of Rybelsus and may occur during the first few weeks of treatment. If this persists or becomes severe, it is important to speak with your healthcare provider.

Another possible side effect of Rybelsus is diarrhoea. This can also occur during the initial stages of treatment as your body adjusts to the medication. It’s essential to stay hydrated if you experience diarrhoea and contact your doctor if it does not improve or worsens over time.

Finally, headaches have been reported as a less common side effect among patients taking Rybelsus medication, but should still be monitored closely. If you experience persistent or severe headaches while on this drug, seek medical attention promptly.

Nausea and Vomiting

Experiencing nausea when taking Rybelsus medication is a common side effect. However, there are ways to manage this and make the process easier. Taking Rybelsus with food or before bed can help reduce feelings of nausea. Additionally, staying hydrated and avoiding foods that trigger your symptoms may also be beneficial.

Vomiting while on Rybelsus medication can be uncomfortable and inconvenient. To avoid this, try taking small sips of water throughout the day, instead of larger meals which may cause discomfort. If you do end up vomiting, make sure to stay hydrated by drinking plenty of fluids and eating bland foods like crackers or toast until you feel better.

It’s important to know when your nausea and vomiting become serious. If you experience severe abdominal pain, bloody vomit or stools, dizziness or fainting with vomiting episodes, then seek medical attention immediately, as these could indicate a more serious problem. As always consult with your healthcare provider if any concerning symptoms arise during treatment with Rybelsus medication for weight management purposes.


If you are experiencing diarrhoea while taking Rybelsus medication, it may be due to some of the side effects associated with the drug. The primary cause could be that it speeds up your digestive system, leading to frequent bowel movements. However, there are ways you can prevent or reduce the severity of diarrhoea when using Rybelsus medication.

To minimise the likelihood of developing diarrhoea while on Rybelsus medication, ensure that you take it as prescribed by your doctor. Also, drink plenty of water and maintain a balanced diet rich in fibre to help regulate bowel movements. If diarrhoea persists for more than two days despite these measures or if you experience other symptoms like fever or severe dehydration, seek medical attention immediately.

Remember that experiencing diarrhoea is a common side effect when taking medications like Rybelsus. Following simple tips such as staying hydrated and eating a healthy diet can help alleviate this problem significantly. However, if problems persist for an extended period even after trying out preventive methods, consult with your physician before continuing any further treatment plan. Additionally, seeking advice before stopping treatment abruptly is advised too.


Using Rybelsus medication to reduce body weight may cause headaches as a side effect in some patients. Common triggers for these headaches include dehydration, changes in blood sugar levels, and stress. To alleviate symptoms caused by the drug, natural remedies such as drinking plenty of water, applying ice packs to the affected area or practising relaxation techniques like deep breathing can help.

The duration of headaches from using Rybelsus varies among individuals and depends on how their bodies respond to the drug. However, most people experience relief within a few days after starting treatment with Rybelsus. If headache symptoms persist or become severe, despite trying natural remedies or over-the-counter pain relievers, it’s important to seek medical advice from your healthcare provider promptly.

What are the serious side effects of Rybelsus?

  • An increased risk of heart attack and stroke
  • Low blood sugar (hypoglycemia) is more common if taken with insulin or a sulfonylurea
  • Kidney problems
  • Diabetic retinopathy
  • Inflammation of the pancreas (pancreatitis)
  • A lump or swelling in your neck (potential thyroid cancer/tumours)
  • Severe allergic reactions such as hives or swelling of the face or throat after taking the medication

There may be risks associated with taking Rybelsus that need to be thoroughly discussed by you and your doctor before beginning treatment. If you experience any of these symptoms while taking Rybelsus, you should immediately seek medical attention.

Patients not suitable for Rybelsus

Rybelsus is not recommended for certain groups of patients:

  • Patients with diabetic ketoacidosis
  • Patients with type 1 diabetes
  • Patients below the age of 18
  • Patients with severe renal or liver impairment
  • Patients with a personal or family history of medullary thyroid carcinoma (MTC)
  • Patients with a rare genetic condition called multiple endocrine neoplasia syndrome type 2
  • Those who are allergic to any of the ingredients in the medication
  • Pregnant women and breastfeeding mothers

Furthermore, risks may be associated with consuming Rybelsus with other medications, so make sure your healthcare provider knows about all your medications and supplements. It’s also important to check whether Rybelsus is safe to use if you have other conditions besides type 2 diabetes. By talking to your healthcare provider and knowing who should avoid taking the medication, you can ensure that your treatment is safe and effective.


In conclusion, Rybelsus medication is an effective treatment for reducing body weight. This medication works by decreasing appetite and increasing feelings of fullness, resulting in fewer calories consumed throughout the day. Clinical studies have confirmed the effectiveness of Rybelsus in achieving weight loss goals.

To achieve maximum results with Rybelsus, it’s important to follow a few tips. Take your medication as prescribed and at the same time each day to establish a routine. It’s also essential to make healthy lifestyle choices, such as eating a balanced diet and engaging in regular physical activity.

Overall, if you’re struggling with body weight issues despite making lifestyle changes on your own, consider speaking with your healthcare provider about whether Rybelsus may be right for you.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Now Patient Data Security

Data Security

Our Commitment to You.

Find out moreNow Patient Data SecurityNow Patient Data Security

What is NowPatient

Online Pharmacy & Telehealth

NowPatient is an online pharmacy & telehealth service that is available in the US and UK. Our service is FREE and packed with useful features that can help you save money on the cost of your medications, access virtual treatments, and provide tools that can help improve your overall health.  Get started today and benefit from medication reminders, private treatment plans, NHS online pharmacy, GP appointment booking, Rx savings card, Drug Coupons, US drug savings programs, health conditions information, Drug Information, genetic testing, home test kits, BMI Risks, Type 2 Diabetes Riskspollen meter, air quality monitor, and lots more!

A laptop screen displays a dashboard with various health metrics and notifications. Widgets include drug coupons, home health testing, genetic risk, diabetes risk, BMI, pollen meter, and air quality.


To improve the lives of everyone by making high-quality care accessible and convenient

We are here to improve lives. Our service gives you access to smart features and resources that can help empower you to take control of your health and improve your health outcomes. All this, in one place, for FREE. We strive to bring a fresh perspective to managing health. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A collage showing a map with pharmacies, a questionnaire, medication details, and a person video chatting on a screen.

Can I trust NowPatient

Meet our medical team

We are a passionate group of clinicians and medical writers covering a broad range of specialities with experience operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process

Your Questions Answered

For your peace of mind, we can answer your questions quickly

We have a comprehensive list of FAQ’s on each feature page. Alternatively, for broader questions around our service just click the button below.
Find your answers