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MEDICAL INFORMATION
Xenical Key Facts
About Xenical
Xenical contains the active ingredient orlistat. It was develpoed by Roche and is used to help people with obesity to lose weight when exercise and dieting alone have not been successful.
It is used in patients who have a body mass index (BMI) of 30 or more, or a BMI of 28 or more if other risk factors are present, such as diabetes, heart disease, or smoking.
Xenical blocks enzymes (lipases) in your intestine from digesting fat, preventing a third of the fat you consume from being absorbed. This undigested fat is passed out of your body with your stools.
NowPatient offers Xenical as a treatment for weight loss only, following an online consultation with a prescribing clinician.
Key facts of Xenical
- For the treatment of weight loss
- When taken in combination with a low calorie-controlled diet and exercise plan, you should see weight loss within the first 13 weeks
- Xenical has some common side effects which include bloating and wind
- It can be dangerous if you take Xenical with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- A dose of Xenical is not necessary if there is no fat within your food
Who is Xenical suitable for?
Xenical is used in patients who have a body mass index (BMI) of 30 or more, or a BMI of 28 or more if other risk factors are present, such as diabetes, heart disease, or smoking.
Who is Xenical not suitable for?
Xenical may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Xenical if you:
- Are allergic to any of the active ingredients of Xenical
- Have chronic malabsorption syndrome
- Have liver problems
How and where to get Xenical?
You can buy Xenical safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of weight loss, you can discuss if Xenical is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Xenical for weight loss
Xenical is available as 120 mg capsules when used for weight loss.
Information about how to take Xenical for weight loss
Take one Xenical 120 mg capsule up to three times a day, with or up to one hour after each main meal. A dose of Xenical is not necessary if you have had a low fat meal or if you skip a main meal. Xenical only works if you have eaten a meal containing dietary fat.
Your doctor will stop Xenical weight loss treatment after 12 weeks if you do not lose at least 5% of your body weight from the start of treatment. You are advised to read the patient information leaflet provided with your medication for further information.
What happens if you take too much Xenical?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Xenical and you experience any of the following side effects:
What are the side effects of Xenical?
Common side effects of Xenical include:
- Abdominal pains
- Bloating
- An urgent need to open the bowels
- Fatty liquidy oily stools
- Constipation
- Flatulence with an oily discharge
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Xenical at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Xenical, but you should let your prescribing clinician know if you are taking medications such as warfarin, levothyroxine, or cyclosporin.
Can Xenical taken for weight loss be taken long term?
If you do not see any results after taking Xenical for 3 months, it may not be suitable for you and should be stopped. If Xenical is working for you, you can take it for up to 2 years.
Is there a herbal Xenical?
No. Herbal Xenical does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Xenical?
Women can take Xenical for weight loss, but is not usually recommended during pregnancy. Speak to your doctor before taking Xenical if you are pregnant, planning to become pregnant, or if you are breastfeeding.
Should I avoid any particular food or drink when taking Xenical?
You can eat and drink normally when taking Xenical. You are advised if you are taking Xenical weight loss medication to take a supplement with your treatment, as you may find it hard to absorb fat-soluble vitamins.
What lifestyle changes can I make to help me with weight loss?
Modify your lifestyle and diet in a number of ways:
- Balanced diet
- Cut back on refined carbohydrates
- Eat more fibre and protein
- Drink water
- Regular exercise
Alternatives to Xenical
Alternatives for the treatment of weight loss include Alli, Saxenda, Wegovy, Ozempic, and Mysimba.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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FAQs
Answers to Popular Questions About Xenical
What is Xenical?
Xenical is the brand name for orlistat 120 mg capsules, manufactured by Roche. It is a prescription-only weight management medication that works by blocking approximately 30% of dietary fat absorption in the gut. Xenical is licensed for use in adults with a BMI of 30 or above, or 28 or above with weight-related risk factors, alongside a calorie-reduced, lower-fat diet. It has been one of the most prescribed weight loss medications worldwide and has been available for over 20 years.
What is the difference between Xenical and Alli?
Xenical and Alli both contain orlistat but at different doses. Xenical contains 120 mg of orlistat and requires a prescription. Alli contains 60 mg of orlistat and is available over the counter. Xenical (120 mg) is approximately twice as potent as Alli (60 mg) in blocking fat absorption and generally produces more weight loss. However, the higher dose also increases the likelihood of gastrointestinal side effects. Generic orlistat 120 mg is also available and is equivalent to Xenical.
How does Xenical work?
Xenical works by irreversibly inhibiting gastric and pancreatic lipase, the enzymes that break down dietary fat in the gut. Approximately 30% of the fat you eat passes through the gut undigested and is excreted in the stool. This creates a calorie deficit contributing to weight loss. The effect occurs locally in the gut with minimal systemic absorption of orlistat (less than 1%), making it one of the safest weight loss medications from a systemic perspective.
How do I take Xenical?
Take one Xenical 120 mg capsule with water immediately before, during, or up to 1 hour after each of your three main meals. If a meal is missed or contains no fat, skip the Xenical dose. Do not take more than 3 capsules per day. Your diet should provide approximately 30% of calories from fat, distributed evenly across meals. Avoid high-fat meals to minimise gastrointestinal side effects. Take a multivitamin containing fat-soluble vitamins at bedtime.
How long should I take Xenical for?
Xenical treatment should be reviewed after 12 weeks. If you have not lost at least 5% of your initial body weight after 12 weeks on full-dose treatment with dietary adherence, continuing Xenical is unlikely to be beneficial. If effective, treatment can continue for up to 2 years based on clinical evidence. Long-term studies show sustained weight loss with continued use. Your prescriber will review your progress regularly.
What are the side effects of Xenical?
The most common side effects relate to unabsorbed fat and include oily/fatty stools, oily spotting, flatulence with oily discharge, faecal urgency, and increased bowel movements. These effects are proportional to fat intake — reducing dietary fat significantly reduces symptoms. Headache, abdominal pain, and upper respiratory infections are also reported. Rare but serious: liver injury (seek help for jaundice, dark urine). Reduced absorption of fat-soluble vitamins requires supplementation.
Does Xenical interact with other medications?
Xenical can reduce the absorption of fat-soluble vitamins and certain medications. It may reduce the absorption of oral contraceptives (if diarrhoea occurs), levothyroxine (separate doses by at least 4 hours), ciclosporin, anticoagulants (warfarin — INR monitoring advised), antiretroviral medications, and antiepileptic drugs. Amiodarone levels may be reduced. Always inform your prescriber of all current medications when starting Xenical.
How can I get Xenical?
Xenical requires a prescription and is available on the NHS or privately through your GP or online services like NowPatient. Generic orlistat 120 mg is usually less expensive than branded Xenical with the same efficacy. NowPatient offers online consultations with qualified UK prescribers and home delivery.
Experienced a Side Effect?
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