Buy Mysimba Online
Mysimba (naltrexone/bupropion) is a prescription weight loss tablet that reduces appetite and controls food cravings. It’s a needle-free, non-GLP-1 alternative to weight loss injections. Get prescribed* by a UK clinician through a free video consultation. No questionnaires, no hidden fees. You only pay if approved.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.
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MEDICAL INFORMATION
Mysimba Key Facts
About Mysimba
Mysimba contains a combination of bupropion hydrochloride, an antidepressant, and naltrexone hydrochloride, an opioid antagonist as its active ingredients, both of which help with weight loss.
Mysimba is an anti-obesity medication, used with a reduced-calorie diet and increased physical activity, for weight management in adults with a body mass index (BMI) of 30 kg/m2, or 27 kg/m2 to < 30 kg/m2, with one or more weight-related health conditions, such as high blood pressure, high cholesterol, or type 2 diabetes. It is thought the naltrexone/bupropion combination reduces a person’s appetite and increases the amount of energy used up by the body.
NowPatient offers Mysimba as a treatment for weight loss only, following an online consultation with a prescribing clinician.
Key facts of Mysimba
- Mysimba is a weight loss treatment taken alongside a healthy diet and exercise plan
- Mysimba usually takes a couple of weeks to show a significant effect
- Mysimba has some common side effects which include nausea and vomiting
- It can be dangerous if you take Mysimba with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Mysimba not suitable for?
Mysimba may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Mysimba if you:
- Have ever had an allergic reaction to the active ingredients bupropion hydrochloride or naltrexone hydrochloride
- Have uncontrolled high blood pressure
- Suffer from seizures
- Have a brain tumour
- Drink alcohol heavily
- Have bipolar disorder
- Have severe liver disease or end-stage kidney disease
- Are taking antidepressants such as monoamine oxidase inhibitors
- Have depression
- Are taking opiate medication or methadone
How and where to get Mysimba?
You can buy Mysimba safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of weight loss, you can discuss if Mysimba is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Mysimba for weight loss
Mysimba is available as 8mg/90mg prolonged-release tablets when used for weight loss.
Information about how to take Mysimba for weight loss
Your dose of Mysimba will change during the first 4 weeks of treatment. The starting Mysimba dose is one tablet each day. From week 4 onwards you will take two tablets twice a day. Mysimba tablets should be taken whole.
Speak to a healthcare professional for further advice and read the patient information leaflet for further information.
What happens if you take too much Mysimba?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Mysimba and you experience any of the following side effects.
What are the side effects of Mysimba?
Possible side effects of Mysimba are split into common and serious.
Common side effects include:
- Nausea
- Vomiting
- Constipation
- Headaches
- Feeling anxious
- Dizziness
- Difficulty sleeping
- Difficulty concentrating
- Tiredness
- Irregular heartbeat
- Hot flushes
- High blood pressure (hypertension)
- Abdominal pain
- Hair loss
- Irritability
Serious side effects include:
- Depression or suicidal thoughts
- Seizures
- Muscle cramps or pain
- Hallucinations
- Unstable blood pressure
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Mysimba at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Mysimba. In any event, you should let your prescribing clinician know if you are taking any herbal supplements.
There are medications that may increase your risk of side effects when taking Mysimba, including:
- Phenelzine, selegiline or rasagiline
- Opiates
- Antidepressants
- Medication for high blood pressure
- Cancer treatments
- Medication for heart disease or stroke
- Medications for seizures
Why might Mysimba not work for weight loss?
Mysimba may not work for you and common reasons may be:
- Deviation from the recommended dose of Mysimba
- Lack of physical activity
- No reduction in calorie intake
Can Mysimba taken for weight loss be taken long term?
If you don’t lose 5% of your body weight after 16 weeks of treatment then you are recommended to stop using Mysimba and try alternative treatments.
Is there a herbal Mysimba?
No. Herbal Mysimba does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Mysimba?
Women can use Mysimba for weight loss. However, you are recommended to speak to your doctor if you are pregnant or plan to become pregnant. Also, speak to your doctor if you are breastfeeding or planning to breastfeed. It is not known if Mysimba passes into breast milk.
Should I avoid any particular food or drink when taking Mysimba?
You can eat and drink normally when taking Mysimba. However, you are recommended not to drink alcohol with Mysimba, as this may increase the risk of some of the side effects such as seizures or mental health issues.
What lifestyle changes can I make to help me with weight loss?
Modify your lifestyle and diet in a number of ways:
- Avoid overeating
- Cut back on refined carbs
- Eat more fibre and protein
- Reduced calorie diet
- Drink water
- Physical activity
Alternatives to Mysimba
Alternatives for the treatment of obesity include Saxenda, Wegovy, Ozempic, and orlistat.
Sources
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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FAQs
Answers to Popular Questions About Mysimba
What is Mysimba?
Mysimba is a prescription oral weight management medication containing two active ingredients: naltrexone hydrochloride 8 mg and bupropion hydrochloride 90 mg per prolonged-release tablet. It is licensed in the UK for chronic weight management in adults with a BMI of 30 or above, or 27 or above with weight-related comorbidities, as an adjunct to a reduced-calorie diet and increased physical activity. Mysimba is an oral alternative to injectable GLP-1 weight loss medications.
How does Mysimba work?
Mysimba works through two complementary mechanisms. Naltrexone is an opioid antagonist that blocks the brain’s opioid reward pathways, reducing food cravings and the pleasurable associations with eating. Bupropion is a dopamine and noradrenaline reuptake inhibitor that acts on the hypothalamic appetite centre to reduce appetite and increase energy expenditure. Together, these two drugs target the mesolimbic reward system and hypothalamic regulation of appetite, addressing both the craving and hunger aspects of overeating.
How much weight can I lose with Mysimba?
In clinical trials (COR programme), patients taking Mysimba alongside lifestyle changes lost an average of 5–8% of their body weight over 56 weeks. Approximately 50% of patients achieved at least 5% weight loss. Weight loss with Mysimba is generally more modest than with GLP-1 receptor agonists like Wegovy (12–15%) but significant enough to improve weight-related health markers. Response should be assessed after 16 weeks — if less than 5% weight loss is achieved, treatment should be reconsidered.
What is the dosing schedule for Mysimba?
Mysimba uses a 4-week dose escalation: Week 1: 1 tablet in the morning; Week 2: 1 tablet morning and 1 tablet evening; Week 3: 2 tablets morning and 1 tablet evening; Week 4 onwards: 2 tablets morning and 2 tablets evening (maintenance dose of 4 tablets daily). Tablets should be swallowed whole with water, preferably with food. Do not crush, break, or chew the prolonged-release tablets. Take morning and evening doses approximately 12 hours apart.
What should I do if I miss a dose?
If you miss a dose, skip the missed dose and take the next dose at your usual time. Do not take a double dose. Continue with the regular dosing schedule. Consistency is important for maintaining therapeutic levels and getting the best results from Mysimba.
What are the common side effects of Mysimba?
Very common side effects include nausea (most common, affecting about 1 in 3 people), constipation, vomiting, and headache. These are most pronounced during the dose escalation phase. Common side effects include dizziness, dry mouth, insomnia, anxiety, tremor, abdominal pain, and increased heart rate. Nausea typically improves after the first 2–4 weeks. Taking Mysimba with food and following the gradual dose escalation helps minimise side effects.
Does Mysimba affect mental health?
Bupropion (one of the components) has been associated with psychiatric side effects including anxiety, insomnia, irritability, and rarely suicidal thoughts. Patients with a history of depression, anxiety, or suicidal ideation should be monitored closely when starting Mysimba. If you experience significant mood changes, agitation, or thoughts of self-harm, stop Mysimba and contact your prescriber immediately. Mysimba is contraindicated in patients with current or history of bipolar disorder, eating disorders (bulimia or anorexia), or seizure disorders.
Who should not take Mysimba?
Mysimba is contraindicated in people with uncontrolled hypertension, seizure disorders or history of seizures, current or history of bulimia or anorexia nervosa, bipolar disorder, current use of opioid-containing medications or during opioid withdrawal, severe hepatic impairment, and end-stage renal failure. It should not be used with MAO inhibitors. Caution is needed with drugs that lower the seizure threshold. Mysimba should not be used during pregnancy or breastfeeding.
Can I drink alcohol while taking Mysimba?
Alcohol consumption should be minimised or avoided while taking Mysimba. Bupropion lowers the seizure threshold, and alcohol further increases seizure risk. Additionally, abruptly stopping heavy alcohol use while on Mysimba increases seizure risk. Naltrexone blocks opioid receptors, which may alter the subjective experience of alcohol. If you regularly drink significant amounts of alcohol, discuss this with your prescriber before starting Mysimba.
How can I get Mysimba?
Mysimba is available on private prescription through your GP or online services like NowPatient. NHS availability varies by area and commissioning policy. NowPatient offers online consultations with qualified UK prescribers who can assess your eligibility and prescribe Mysimba with home delivery.
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