Treatment options

Buy MYSIMBA safely, securely and easily in a few simple steps. Start a consultation today to check your eligibility with a prescribing clinician, at no cost to you.

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Manufactured by Orexigen


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Dispensed in the UK
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Updated on 26 Mar 2024

What to do if you missed your MYSIMBA dose

The MHRA's reporting program for suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.

Learn more about reporting side effects

About Mysimba

Mysimba contains a combination of bupropion hydrochloride, an antidepressant, and naltrexone hydrochloride, an opioid antagonist as its active ingredients, both of which help with weight loss.

Mysimba is an anti-obesity medication, used with a reduced-calorie diet and increased physical activity, for weight management in adults with a body mass index (BMI) of 30 kg/m2, or 27 kg/m2 to < 30 kg/m2, with one or more weight-related health conditions, such as high blood pressure, high cholesterol, or type 2 diabetes. It is thought the naltrexone/bupropion combination reduces a person’s appetite and increases the amount of energy used up by the body.

NowPatient offers Mysimba as a treatment for weight loss only, following an online consultation with a prescribing clinician.

Key facts of Mysimba

  • Mysimba is a weight loss treatment taken alongside a healthy diet and exercise plan
  • Mysimba usually takes a couple of weeks to show a significant effect
  • Mysimba has some common side effects which include nausea and vomiting
  • It can be dangerous if you take Mysimba with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician

Who is Mysimba not suitable for?

Mysimba may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Mysimba if you:

  • Have ever had an allergic reaction to the active ingredients bupropion hydrochloride or naltrexone hydrochloride
  • Have uncontrolled high blood pressure
  • Suffer from seizures
  • Have a brain tumour
  • Drink alcohol heavily
  • Have bipolar disorder
  • Have severe liver disease or end-stage kidney disease
  • Are taking antidepressants such as monoamine oxidase inhibitors
  • Have depression
  • Are taking opiate medication or methadone

How and where to get Mysimba?

Mysimba is available with a prescription only. It is not available over the counter at a pharmacy.

NowPatient does not allow customers to buy Mysimba directly. Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of weight loss, you can discuss if Mysimba is a suitable treatment option for you.

At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.

Dosage and strength for Mysimba for weight loss

Mysimba is available as 8mg/90mg prolonged-release tablets when used for weight loss.

Information about how to take Mysimba for weight loss

Your dose of Mysimba will change during the first 4 weeks of treatment. The starting Mysimba dose is one tablet each day. From week 4 onwards you will take two tablets twice a day. Mysimba tablets should be taken whole.

Speak to a healthcare professional for further advice and read the patient information leaflet for further information.

What happens if you take too much Mysimba?

If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Mysimba and you experience any of the following side effects.

What are the side effects of Mysimba?

Possible side effects of Mysimba are split into common and serious.

Common side effects include:

  • Nausea
  • Vomiting
  • Constipation
  • Headaches
  • Feeling anxious
  • Dizziness
  • Difficulty sleeping
  • Difficulty concentrating
  • Tiredness
  • Irregular heartbeat
  • Hot flushes
  • High blood pressure (hypertension)
  • Abdominal pain
  • Hair loss
  • Irritability

Serious side effects include:

  • Depression or suicidal thoughts
  • Seizures
  • Muscle cramps or pain
  • Hallucinations
  • Unstable blood pressure

If you experience any serious side effects, you should contact NHS 111.

If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.

  • Your lips, mouth, throat or tongue suddenly become swollen
  • You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • Your throat feels tight or you’re struggling to swallow
  • Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • You suddenly become very confused, drowsy or dizzy
  • Someone faints and cannot be woken up

Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient

Information about taking Mysimba at the same time as other medications or herbal supplements

There is not enough evidence to suggest there are any drug interactions between herbal supplements and Mysimba. In any event, you should let your prescribing clinician know if you are taking any herbal supplements.

There are medications that may increase your risk of side effects when taking Mysimba, including:

  • Phenelzine, selegiline or rasagiline
  • Opiates
  • Antidepressants
  • Medication for high blood pressure
  • Cancer treatments
  • Medication for heart disease or stroke
  • Medications for seizures

Why might Mysimba not work for weight loss?

Mysimba may not work for you and common reasons may be:

  • Deviation from the recommended dose of Mysimba
  • Lack of physical activity
  • No reduction in calorie intake

Can Mysimba taken for weight loss be taken long term?

If you don’t lose 5% of your body weight after 16 weeks of treatment then you are recommended to stop using Mysimba and try alternative treatments.

Is there a herbal Mysimba?

No. Herbal Mysimba does not exist. If you have been marketed such a formulation, it may be fake.

Can women use Mysimba?

Women can use Mysimba for weight loss. However, you are recommended to speak to your doctor if you are pregnant or plan to become pregnant. Also, speak to your doctor if you are breastfeeding or planning to breastfeed. It is not known if Mysimba passes into breast milk.

Should I avoid any particular food or drink when taking Mysimba?

You can eat and drink normally when taking Mysimba. However, you are recommended not to drink alcohol with Mysimba, as this may increase the risk of some of the side effects such as seizures or mental health issues.

What lifestyle changes can I make to help me with weight loss?

Modify your lifestyle and diet in a number of ways:

  • Avoid overeating
  • Cut back on refined carbs
  • Eat more fibre and protein
  • Reduced calorie diet
  • Drink water
  • Physical activity

Alternatives to Mysimba

Alternatives for the treatment of obesity include Saxenda, Wegovy, Ozempic, and orlistat.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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