Premique Low Dose
Book a quick face-to-face video consultation with a certified prescribing pharmacist, nurse, or doctor. If approved, your Premique Low Dose will be prescribed* and delivered straight to your door with free next-day delivery†. No hidden fees. No delays. Just expert care.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.


Other Related Treatments
MEDICAL INFORMATION
Premique Low Dose Key Facts
Other Related Names or Treatments
Elleste Solo, Premarin
About Premique Low Dose
Premique Low Dose is a hormone replacement therapy (HRT), used to treat the symptoms of menopause. It contains two active ingredients, conjugated oestrogens (an estrogen) and medroxyprogesterone acetate (a progesterone).
If only oestrogen levels are increased during HRT treatment, the endometrium would grow excessively, causing an increased risk of endometrial cancer. This is why Premique Low Dose (which contains a progestogen) is prescribed if you have not had a hysterectomy.
Premique Low Dose helps to treat menopausal symptoms such as:
- Osteoporosis
- Hot flushes
- Night sweats
- Depression
- Sleep problems
- Vaginal dryness
NowPatient offers Premique Low Dose as a treatment for HRT only, following an online consultation with a prescribing clinician.
Key facts of Premique Low Dose
- For the treatment of HRT
- Premique Low Dose has some common side effects which include nausea and headaches
- Premique Low Dose will not prevent pregnancy in otherwise fertile women
- Do not use a hormonal contraceptive when treated with a HRT
- It can be dangerous if you take Premique Low Dose with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Premique Low Dose not suitable for?
Premique Low Dose may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Premique Low Dose if you:
- Are allergic to conjugated oestrogens or medroxyprogesterone acetate
- Have ever had breast cancer
- Have cancer sensitive to oestrogen
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clots
- Suffer from porphyria
- Have had a heart attack, angina, stroke, or high blood pressure
- Have unusual vaginal bleeding
- Have liver disease or any other liver problems
- Are pregnant or breastfeeding
- Have fibroids
- Have uterine problems such as endometriosis or endometrial hyperplasia
- Have diabetes
- Suffer from migraines
- Have gallbladder disease
- Have asthma
- Have epilepsy
- Have fluid retention
- Have high cholesterol levels in the blood
- Are obese
- Have a hereditary ear disorder
How and where to get Premique Low Dose?
You can buy Premique Low Dose safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with one of our prescribers for the treatment of HRT, you can discuss if Premique Low Dose is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Premique Low Dose for HRT
Premique Low Dose is available in tablet form containing 300 mcg of conjugated oestrogens and 1.5 mg of medroxyprogesterone acetate.
Information about how to take Premique Low Dose for HRT
Premique Low Dose tablets should be taken at the same time each day. Swallow the tablets whole with water, with or without food. Start a new pack the day after you have finished your current pack. If you forget to take a tablet, take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Read the patient information leaflet provided or speak to a healthcare professional for further information.
What happens if you take too much Premique Low Dose?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Premique Low Dose and you experience any of the following side effects.
What are the side effects of Premique Low Dose?
Side effects of Premique Low Dose are split into common and serious.
Common side effects include:
- Nausea
- Headache
- Breast tenderness
- Breast pain
- Breakthrough bleeding
- Change in sex drive
- Stomach cramps
- Fluid retention, bloating
Serious side effects include:
- Blood clots (pulmonary embolism, deep vein thrombosis)
- Stroke
- Heart disease – chest pain passing into the neck or arm
- Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Premique Low Dose at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Premique Low Dose. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:
- Phenytoin or carbamazepine
- Rifampicin
- Ritonavir or nelfinavir
- Warfarin
- St John’s Wort
- Grapefruit juice
Can Premique Low Dose taken for HRT be taken long term?
HRT should only be used as a short-term treatment for the menopause. Speak to your GP to review your treatment at least once each year and have regular checkups.
Is there a herbal Premique Low Dose?
No. Herbal Premique Low Dose does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Premique Low Dose?
Women can take Premique Low Dose for HRT, but should speak to a doctor if considering taking it while pregnant or breastfeeding.
Should I avoid any particular food or drink when taking Premique Low Dose?
You can eat and drink normally when taking Premique Low Dose.
What lifestyle changes can I make to help me with menopause?
You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:
- Using a fan
- Cool showers
- Light clothing
- Lubricants
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Premique Low Dose
Alternative oestrogen-only HRT include Premarin, Progynova and Zumenon.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Premique Low Dose
What is Premique Low Dose?
Premique Low Dose is a continuous combined HRT containing conjugated equine oestrogens 0.3 mg and medroxyprogesterone acetate (MPA) 1.5 mg per tablet. It is a lower-dose version of Premique designed for postmenopausal women (at least 12 months since last period) who need combined, bleed-free HRT. It is taken daily without a break.
How does Premique Low Dose differ from standard Premique?
Premique Low Dose contains lower doses of both the oestrogen and progestogen components compared to standard Premique. This reflects the clinical principle of using the lowest effective dose of HRT to minimise side effects and risks while adequately controlling symptoms.
How do I take Premique Low Dose?
Take one tablet daily at the same time, continuously without a break. Swallow with water, with or without food. All tablets are identical.
What are the side effects of Premique Low Dose?
Common side effects include breast tenderness, headaches, nausea, bloating, and mood changes. Breakthrough bleeding may occur in the first 3–6 months. As an oral combined HRT, it carries a small increased risk of VTE and, with prolonged use, breast cancer. Women with VTE risk factors may benefit from switching to transdermal HRT.
Is Premique Low Dose still recommended?
While Premique remains licensed, modern UK guidelines favour body-identical oestradiol-based HRT with micronised progesterone. Premique uses conjugated equine oestrogens and a synthetic progestogen. If you are stable on Premique Low Dose, there is no urgent need to switch, but discuss body-identical alternatives with your prescriber at your next review.
How can I get Premique Low Dose?
Premique Low Dose is available on NHS prescription from your GP or menopause clinic, or through NowPatient’s online service.
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