Premarin
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MEDICAL INFORMATION
Premarin Key Facts
Other Related Names or Treatments
Elleste Solo
About Premarin
Premarin tablets are a form of HRT (hormone replacement therapy), used to treat the symptoms of the menopause. Premarin tablets contains conjugated estrogens, a mixture of sulfate esters of estrone, equilin sulfates, 17a-estradiol and 17b-estradiol. Premarin is suitable for women who have had a hysterectomy.
Symptoms of menopause include:
- Osteoporosis
- Hot flashes
- Depression
- Sleep problems
- Vaginal dryness
NowPatient offers Premarin as a treatment for HRT only, following an online consultation with a prescribing clinician.
Key facts of Premarin
- For the treatment of HRT
- Premarin has some common side effects which include nausea and headaches
- Premarin will not prevent pregnancy in otherwise fertile women
- Do not use a hormonal contraceptive when treated with a HRT
- It can be dangerous if you take Premarin with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Premarin not suitable for?
Premarin may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Premarin if you:
- Are allergic to the active ingredient, estradiol hemihydrate
- Have ever had breast cancer
- Have cancer sensitive to oestrogen
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clots
- Suffer from porphyria
- Have had a heart attack, angina, stroke, or high blood pressure
- Have unusual vaginal bleeding
- Have liver disease or any other liver problems
- Are pregnant or breastfeeding
- Have fibroids
- Have uterine problems such as endometriosis or endometrial hyperplasia
- Have diabetes
- Suffer from migraines
- Have gallbladder disease
- Have asthma
- Have epilepsy
- Have fluid retention
- Have high cholesterol levels in the blood
- Are obese
- Have a hereditary ear disorder
How and where to get Premarin?
You can buy Premarin safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with one of our prescribers for the treatment of HRT, you can discuss if Premarin is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Premarin for HRT
Premarin is available as 0.3mg, 0.625mg & 1.25mg tablets when used for HRT.
Information about how to take Premarin for HRT
Premarin tablets should be taken at the same time each day. Swallow the tablets whole with water, with or without food. If you forget to take a tablet, take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Read the patient information leaflet provided or speak to a healthcare professional for further information.
What happens if you take too much Premarin?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Premarin and you experience any of the following side effects.
What are the side effects of Premarin?
In clinical trials, side effects of Premarin are split into common and serious.
Common side effects include:
- Nausea
- Headache
- Breast tenderness
- Breast pain
- Breakthrough bleeding
- Change in sex drive
- Stomach cramps
- Fluid retention, bloating
Serious side effects include:
- Blood clots (pulmonary embolism, deep vein thrombosis)
- Stroke
- Heart disease – chest pain passing into the neck or arm
- Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Premarin at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Premarin. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:
- Phenytoin or carbamazepine
- Rifampicin
- Ritonavir or nelfinavir
- Warfarin
- St John’s Wort
- Grapefruit juice
Can Premarin taken for HRT be taken long term?
HRT should only be used as a short-term treatment for the menopause. Speak to your GP to review your treatment at least once each year and have regular checkups.
Is there a herbal Premarin?
No. Herbal Premarin does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Premarin?
Women can take Premarin for HRT, but should speak to a doctor if considering taking while pregnant or breastfeeding.
Should I avoid any particular food or drink when taking Premarin?
You can eat and drink normally when taking Premarin.
What lifestyle changes can I make to help me with menopause?
You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:
- Using a fan
- Cool showers
- Light clothing
- Lubricants
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Premarin
Alternative oestrogen-only HRT include Progynova and Zumenon.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Premarin
What is Premarin?
Premarin is an oestrogen-only hormone replacement therapy (HRT) containing conjugated equine oestrogens (CEE) 0.3 mg, 0.625 mg, or 1.25 mg. Conjugated oestrogens are derived from the urine of pregnant mares and contain a mixture of oestrogen compounds. Premarin has been used for menopausal symptom relief since the 1940s and is one of the most studied HRT products. It is used to treat vasomotor symptoms (hot flushes, night sweats), vulvovaginal atrophy, and osteoporosis prevention in postmenopausal women.
How does Premarin differ from other oestrogen HRT?
Premarin contains conjugated equine oestrogens, which is a mixture of oestrogen compounds rather than a single molecule like oestradiol (used in Elleste Solo, Evorel, and Femoston). Modern prescribing guidelines tend to favour body-identical oestradiol-based HRT products, as oestradiol is molecularly identical to the oestrogen produced by the human ovary. However, Premarin remains licensed and effective, and some women prefer it, particularly those who have used it successfully for years.
Who can take Premarin?
Premarin is used for postmenopausal women with moderate to severe vasomotor symptoms or vulvovaginal atrophy. As an oestrogen-only product, it is most appropriate for women who have had a hysterectomy. Women with an intact uterus must take a progestogen alongside Premarin (or use Premique, which combines CEE with medroxyprogesterone acetate). Premarin should not be used in women with active breast cancer, undiagnosed vaginal bleeding, active VTE, or severe liver disease.
How do I take Premarin?
Take one Premarin tablet daily at the same time, continuously without a break. The usual starting dose is 0.625 mg, but your prescriber may start at a lower dose (0.3 mg) and adjust based on symptom response. Swallow the tablet whole with water. It can be taken with or without food.
How long should I take Premarin?
HRT duration should be reviewed annually. Use the lowest effective dose for the shortest duration needed to control symptoms. Some women take HRT for many years if the benefits outweigh the risks. NICE does not recommend an arbitrary time limit. If you wish to stop, your prescriber may suggest tapering the dose gradually.
What are the side effects of Premarin?
Common side effects include breast tenderness, headaches, nausea, bloating, fluid retention, and leg cramps. Breakthrough bleeding may occur. Less common effects include mood changes, changes in libido, and skin reactions. These often improve within the first 3 months of treatment.
What are the risks of taking Premarin?
Oral conjugated oestrogens are associated with a small increased risk of VTE (blood clots), stroke, and — when combined with progestogen — breast cancer. These risks increase with age and duration of use. Premarin was the oestrogen used in the Women’s Health Initiative study. Transdermal oestradiol (patches, gels) may have a lower VTE and stroke risk than oral oestrogens. Discuss your individual risk profile with your prescriber.
Is Premarin still recommended?
Premarin remains licensed and available, but modern UK prescribing guidelines from NICE and the British Menopause Society (BMS) tend to favour body-identical oestradiol-based HRT. Oestradiol is molecularly identical to human oestrogen and is available in a wider range of formulations (tablets, patches, gels). However, if you are stable and well on Premarin, there is no automatic need to switch. Discuss options with your prescriber.
How can I get Premarin?
Premarin is available on NHS prescription from your GP, menopause specialist, or through online services like NowPatient. Your prescriber may discuss whether body-identical oestradiol-based HRT might be more appropriate for you. NowPatient offers online consultations and home delivery.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
Report to
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