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Astellas Pharma Ltd. has announced the authorisation by the Medicines and Healthcare products Regulatory Agency (MHRA) of Veoza (fezolinetant) for the treatment of moderate to severe vasomotor symptoms (hot flushes and night sweats) associated with menopause.
Veoza is a neurokinin-3 receptor antagonist that targets the hypothalamus (the brain’s temperature control centre) where vasomotor symptoms (VMS) are triggered by an imbalance between oestrogens (a female sex hormone) and neurokinin B (a protein made by the brain). Fezolinetant blocks neurokinin B binding in the hypothalamus, preventing VMS and reducing the intensity and number of hot flashes and night sweats.
Now Patient offers Veoza as a treatment for moderate to severe vasomotor symptoms only, following an online consultation with a prescribing clinician.
Key facts of Veoza
- For the treatment of moderate to severe VMS
- Veoza has some common side effects which include diarrhoea and insomnia
- It can be dangerous if you take Veoza with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Veoza not suitable for?
Veoza may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Veoza if you:
- Are allergic to the active substance fezolinetant or to any of the inactive ingredients
- Are, or think you may be pregnant
- Have Child-Pugh Class B or C chronic hepatic impairment
- Have severe renal impairment or end-stage renal disease
- Have known or previous breast cancer sensitive to oestrogen
- Are using hormone replacement therapy with oestrogens
- Are taking moderate or strong CYP1A2 inhibitors
How and where to get Veoza?
Veoza is available with a prescription only. It is not available over the counter at a pharmacy.
Now Patient does not allow customers to buy Veoza directly. Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of VMS, you can discuss if Veoza is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by Now Patient.
Dosage and strength for Veoza for VMS
Veoza is available as 45 mg film-coated tablets when used for VMS.
Information about how to take Veoza for VMS
The recommended dose of Veoza is 45 mg once daily, at the same time each day with or without food. Veoza tablets should be swallowed whole with water. Do not break, crush, or chew the tablets.
If you forget to take a dose of Veoza take the missed dose as soon as possible, unless your next dose is due in less than 12 hours. Resume your regular dosing schedule the next day. Read the patient information leaflet or speak to a healthcare provider for further information.
What happens if you take too much Veoza?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Veoza and you experience any of the following side effects:
- Paraesthesia (pins and needles)
What are the side effects of Veoza?
In clinical trials, when compared to placebo, side effects of Veoza are split into common and serious. Common side effects include:
- Abdominal pain
- Back pain
Serious side effects include:
- Liver damage
- Endometrial cancer
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Veoza at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Veoza. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or prescription drugs, such as:
- Strong or moderate CYP1A2 inhibitors such as contraceptives containing ethinyl estradiol, mexiletine, enoxacin, or fluvoxamine
Is there a herbal Veoza?
No. Herbal Veoza does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Veoza?
Women can take Veoza for the treatment of VMS. However, Veoza is not recommended during pregnancy or if breastfeeding. It is not known if this medication passes into breast milk. Speak to your doctor for further medical advice.
Should I avoid any particular food or drink when taking Veoza?
You can eat and drink normally when taking Veoza.
What lifestyle changes can I make to help me with VMS?
You may modify your lifestyle in a number of ways to improve your quality of life and have a positive impact on your menopause symptoms:
- Using a fan
- Cool showers
- Light clothing
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Veoza
Alternatives for the treatment of VMS includes HRT treatment such as Premarin or Kliofem tablets, or Evorel patches.
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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