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MEDICAL INFORMATION
Evorel Key Facts
Other Related Names or Treatments
Estraderm, Estradot
About Evorel
Evorel patches are classed as a hormone replacement therapy (HRT). It contains estradiol, which acts in the same way as the female sex hormone oestrogen and is used to treat the symptoms of menopause.
If only oestrogen levels are increased during HRT treatment, the endometrium would grow excessively, causing an increased risk of endometrial cancer. If you have not had a hysterectomy you will be prescribed a progestogen with Evorel.
Evorel helps to treat menopausal symptoms such as:
- Osteoporosis
- Hot flushes, night sweats
- Depression, mood swings
- Sleep problems
- Vaginal dryness
NowPatient offers Evorel patches as a treatment for HRT only, following an online consultation with a prescribing clinician.
Key facts of Evorel
- For the treatment of HRT
- Evorel has some common side effects which include nausea and headaches
- Evorel will not prevent pregnancy in otherwise fertile women
- Do not use a hormonal contraceptive when treated with a HRT
- It can be dangerous if you use Evorel with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- Evorel Conti patches (50mcg estradiol and 170mcg norethisterone acetate) are used in postmenopausal women who have not had a period in the last 18 months
Who is Evorel not suitable for?
Evorel may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before using Evorel if you:
- Have hypersensitivity to the active ingredients estradiol
- Have ever had breast cancer
- Have cancer sensitive to oestrogen
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clots
- Suffer from porphyria
- Have had a heart attack, angina, stroke, or high blood pressure
- Have unusual vaginal bleeding
- Have liver disease or any other liver problems
- Are pregnant or breastfeeding
- Have fibroids
- Have uterine problems such as endometriosis or endometrial hyperplasia
- Have diabetes
- Suffer from migraines
- Have gallbladder disease
- Have asthma
- Have epilepsy
- Have fluid retention
- Have high cholesterol levels in the blood
- Are obese
- Have a hereditary ear disorder
How and where to get Evorel?
You can buy Evorel safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of HRT, you can discuss if Evorel is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Evorel patches for HRT
Evorel patches contain estradiol as the active ingredient. It is available as:
- Evorel 25 which gives 25mcg of estradiol in 24 hours
- Evorel 50 which gives 50mcg of estradiol in 24 hours
- Evorel 100 which gives 100mcg of estradiol in 24 hours
Information about how to use Evorel for HRT
The Evorel patch should be applied to a clean and dry area of skin. You may choose to apply the patch to your thighs or bottom. The patch must be changed twice a week, on the same two days each week. You should not apply the new patch to the same area of skin and do not apply the patch around your breasts. Read the patient information leaflet provided or speak to a healthcare professional for further information.
What happens if you use too much Evorel?
If you use more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have used too much Evorel and you experience any of the following side effects:
What are the side effects of Evorel?
Side effects of Evorel are split into common and serious.
Common side effects include:
- Nausea
- Headache, dizziness
- Breast tenderness, breast pain
- Change in sex drive
- Anxiety, insomnia
- Stomach pain, indigestion, flatulence, diarrhoea
- Irregular bleeding
- Acne, skin irritation, rash
- Vaginal discharge
- Fluid retention, weight gain, bloating
Serious side effects include:
- Blood clots
- Stroke
- Heart disease – chest pain passing into the neck or arm
- Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about using Evorel at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Evorel. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:
- Phenytoin or carbamazepine
- Rifampicin
- Ritonavir or nelfinavir
- Warfarin
- St John’s Wort
Can Evorel used for HRT be used long term?
HRT should only be used as a short-term treatment for the menopause. Women who use HRT for more than 5 years may be at an increased risk of ovarian cancer. Speak to your GP to review your treatment at least once each year and have regular checkups.
Is there a herbal Evorel?
No. Herbal Evorel does not exist. If you have been marketed such a formulation, it may be fake.
Should I avoid any particular food or drink when using Evorel?
You can eat and drink normally when using Evorel.
What lifestyle changes can I make to help me with HRT?
You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:
- Using a fan
- Cool showers
- Light clothing
- Lubricants
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Evorel
Alternative HRT patches include Estaderm and Estradot patches.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Evorel
What is Evorel?
Evorel is an oestrogen-only HRT patch containing oestradiol. It is available in three strengths: Evorel 25 (25 mcg/24h), Evorel 50 (50 mcg/24h), and Evorel 100 (100 mcg/24h). The patches deliver oestradiol through the skin (transdermally), bypassing the liver and gastrointestinal tract. Evorel is used for menopausal symptom relief and is particularly suitable for women who prefer patches to tablets or who have VTE risk factors. It is manufactured by Jannsen-Cilag.
How do Evorel patches work?
Evorel patches contain oestradiol embedded in an adhesive matrix. When applied to the skin, oestradiol is absorbed steadily through the skin into the bloodstream. This provides a consistent hormone level throughout the day, avoiding the peaks and troughs of oral HRT. Transdermal oestradiol does not undergo first-pass liver metabolism, which means it does not increase the risk of blood clots (VTE) or affect clotting factors — a significant advantage over oral HRT.
Who is Evorel suitable for?
Evorel (oestrogen-only) is primarily for women who have had a hysterectomy. Women with an intact uterus must add a progestogen. Evorel patches are particularly recommended for women with VTE risk factors (obesity, family history of clots), women over 60, women with migraine, those with liver disease, and women taking enzyme-inducing medications. NICE and BMS guidance favours transdermal oestrogen for these groups.
How do I apply Evorel patches?
Apply one patch to clean, dry, non-irritated skin on the lower trunk (below the waist), buttocks, or upper thigh. Avoid the breasts, waistline, and areas where clothing may rub. Press firmly for 10–15 seconds to ensure good adhesion. Change the patch twice weekly (every 3–4 days). Rotate the application site to prevent skin irritation — do not apply to the same area within 7 days. The patch can be worn during bathing and swimming.
What if my Evorel patch falls off?
If the patch falls off within the first 24 hours, reapply the same patch to a different area or apply a new one. If it falls off after 24 hours, apply a new patch and continue with your usual schedule. If a patch repeatedly falls off, ensure the skin is clean, dry, and free from lotions, oils, or creams before application. Avoid applying patches after hot baths or saunas as the skin may be too moist for adhesion.
What are the side effects of Evorel?
Common side effects include skin irritation at the patch site (redness, itching), headaches, breast tenderness, nausea, and bloating. Application site reactions usually resolve with site rotation. If skin irritation is persistent, discuss alternative transdermal formulations (gels) or patch brands with your prescriber. Systemic side effects are generally milder than with oral HRT due to steady hormone delivery.
Does Evorel increase the risk of blood clots?
No, transdermal oestradiol (including Evorel) does not increase the risk of venous thromboembolism (VTE). This is a key advantage over oral HRT. Transdermal delivery avoids first-pass liver metabolism and does not affect clotting factor production. Evorel is the preferred route of oestrogen delivery for women with VTE risk factors.
How can I get Evorel?
Evorel patches are available on NHS prescription from your GP, menopause clinic, or through NowPatient’s online service. They are often recommended as a first-line HRT option due to the safety advantages of transdermal delivery.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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