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MEDICAL INFORMATION
Blissel Gel Key Facts
Other Related Names or Treatments
Vagifem, Ovestin cream, Estring
About Blissel Gel
Blissel vaginal gel contains the active ingredient estriol, developed to treat symptoms of vaginal atrophy due to menopause. Estriol replenishes estrogen levels in the vaginal tissues, helping to restore a normal vaginal environment and prevent symptoms such as dryness, itching, burning, and painful intercourse by promoting the regeneration of the vaginal epithelium and maintaining vaginal health.
Blissel Gel is a prescription-only medication and may be recommended when other topical treatments have not been effective or are not well tolerated.
NowPatient offers Blissel Gel as a treatment for vaginal atrophy due to menopause, following an online consultation with a prescriber.
Key facts of Blissel Gel
- For the treatment of vaginal atrophy
- Blissel Gel has some common side effects which include vaginal irritation, vaginal discharge and vaginal infection
- If you’re not sure if it is safe to use with other treatments, discuss this with the prescribing clinician
- Blissel Gel is not a contraceptive
- Blissel Gel should generally be used when other treatments have not been effective or are not suitable
- You should stop using Blissel Gel if your condition has cleared up and your prescriber advises it is no longer needed
Who is Blissel Gel suitable for?
Blissel Gel is suitable for women experiencing menopausal symptoms, such as vaginal dryness, itching, burning or irritation.
Who is Blissel Gel not suitable for?
Blissel Gel may not be suitable for some people. To make sure it’s safe for you, speak to the NowPatient prescribing clinician before using Blissel Gel if you:
- Are pregnant or planning to become pregnant
- Are breastfeeding
- Have a history of allergic reactions to any ingredients in Blissel Gel
- Have or have ever had breast cancer
- Have cancer which is sensitive to oestrogens
- Have any unexplained vaginal bleeding
- Have excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated
- Have or have ever had a blood clot in a vein
- Have a blood clotting disorder
- Have or recently have had a heart attack, stroke or angina
- Have or have ever had liver disease
- Have porphyria, a rare blood disorder
How and where to get Blissel Gel?
You can buy Blissel Gel safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of vaginal atrophy, you can discuss if Blissel Gel is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Blissel Gel for vaginal atrophy
Blissel Gel comes in a 30g tube. Initially apply one application daily for the first few weeks. After the initial treatment period, the usual dose is one application twice a week or as directed.
What happens if you use too much Blissel Gel?
Do not worry if you have applied too much Blissel Gel at any time. You should however speak to a doctor or reach out to one of our prescribing clinicians for advice. You may feel or be sick and may have some vaginal bleeding after a few days.
What are the side effects of Blissel Gel?
Side effects of Blissel Gel are split into common and serious.
Common side effects include:
- Itching, local irritation in or around the vagina
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below, you should contact emergency services on 999:
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA Yellow Card reporting system. You can read more about this here: How and where do I report side effects of my medication?
Information about using Blissel Gel with other medications
Tell your doctor if you are taking other medicines, including those obtained without a prescription or herbal medicines. Blissel Gel is for local treatment and is therefore not expected to affect or be affected by other medicines. Interactions with other locally applied vaginal treatments should however be considered.
Why might Blissel Gel not work for vaginal atrophy?
Blissel Gel may not work for vaginal atrophy if the dose is too low, if the gel is not well absorbed, or if it is the wrong treatment for your specific cause of vaginal atrophy.
Can Blissel Gel be used long term?
Blissel Gel can be used long term for vaginal dryness and other menopausal symptoms as long as your clinician recommends it.
How to store Blissel Gel
- Keep Blissel Gel out of the sight and reach of children
- Do not use this medicine after the expiry date shown on the carton and tube/pump (marked as “EXP”). The expiry date refers to the last day of that month
- Discard the tube 6 months after first opening
- Store below 25 degrees celsius
- Do not dispose of unused Blissel Gel in wastewater or household waste. Ask your pharmacist how to properly dispose of medicines you no longer use. These steps help protect the environment.
Is there a herbal Blissel Gel?
No. Herbal Blissel Gel does not exist. If you have been marketed such a product, it may be counterfeit or unsafe.
Should I avoid any particular food or drink when using Blissel Gel?
You can eat and drink normally while using Blissel Gel. Maintaining a balanced diet can help manage menopause symptoms and contribute to overall well-being.
What lifestyle changes can I make to help with vaginal atrophy?
There are several lifestyle changes that may improve your symptoms. These include:
- Exercise
- A healthy diet
- Staying sexually active
- Avoiding smoking and excessive alcohol
- Using lubricants during intercourse
Alternatives to Blissel Gel
Alternatives for the treatment of vaginal atrophy include:
- Vagifem
- Ovestin cream
- Estring
Your prescriber will help decide which option is most suitable for your condition.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Blissel Gel
What is Blissel Gel?
Blissel Gel is a vaginal gel containing estriol 50 micrograms per gram, used for the treatment of vaginal atrophy (atrophic vaginitis) caused by oestrogen deficiency, typically in postmenopausal women. Estriol is a weak, short-acting natural oestrogen that acts locally on vaginal tissue to restore thickness, lubrication, and the normal acidic vaginal pH. Blissel is applied intravaginally using a calibrated applicator. It is a prescription-only medicine.
How does Blissel Gel work?
Blissel delivers low-dose estriol directly to the vaginal tissues. Estriol stimulates oestrogen receptors in the vaginal epithelium, promoting cell proliferation, increasing blood flow, restoring natural secretions, and lowering vaginal pH to the normal acidic range (which protects against infections). Because estriol is a weak, short-acting oestrogen with minimal systemic absorption, it has an excellent safety profile and does not require additional progestogen protection of the endometrium.
How do I use Blissel Gel?
Using the calibrated applicator, insert one dose (1 g of gel containing 50 mcg estriol) intravaginally once daily for 2–3 weeks, then reduce to twice weekly as maintenance. Apply at bedtime for convenience. Insert the applicator gently into the vagina and press the plunger to deliver the gel. Clean the applicator after each use. Improvement in symptoms (dryness, itching, discomfort during intercourse) is usually noticed within 2–3 weeks.
What are the side effects of Blissel Gel?
Side effects are generally mild and localised. Common effects include vaginal irritation, itching, or burning (particularly when first starting treatment). Breast tenderness and vaginal bleeding/spotting may occasionally occur. Systemic side effects are rare due to the minimal absorption of estriol. If vaginal bleeding occurs, especially if unexpected, consult your prescriber for investigation.
Is Blissel safe for breast cancer survivors?
Low-dose vaginal estriol products like Blissel have minimal systemic absorption and are generally considered safe. However, the use of any oestrogen-containing product in women with a history of oestrogen-receptor-positive breast cancer should be discussed with their oncologist. Some specialists do permit low-dose vaginal estriol in carefully selected patients. Non-hormonal alternatives include vaginal moisturisers and lubricants.
How can I get Blissel Gel?
Blissel Gel requires a prescription from your GP, menopause specialist, or online prescriber such as NowPatient. It is available on the NHS. Other vaginal oestrogen options (Vagifem tablets, Estring ring) are also available and your prescriber can advise on the most suitable formulation.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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