Buy Evorel Sequi Online. No Consultation Fee, Free Next-Day Delivery†
Get prescribed Evorel Sequi for Menopause by a UK clinician through a free video consultation*. No questionnaires, no hidden fees. You only pay for your medication if approved.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.
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MEDICAL INFORMATION
Evorel Sequi Key Facts
Other Related Names or Treatments
Estraderm, Estradot
About Evorel Sequi patches
Evorel Sequi patches are classed as a sequential hormone replacement therapy (HRT) used to treat the symptoms of menopause. Evorel Sequi contains two types of patches, Evorel 50 which contains the sex hormone estradiol (an oestrogen), and Evorel Conti patches which contain estradiol and norethisterone (a progesterone). Evorel Sequi patches are normally used in postmenopausal women who have not had a period in the last 18 months.
If only oestrogen levels are increased during HRT treatment, the endometrium would grow excessively, causing an increased risk of endometrial cancer. This is why Evorel Sequi patches (which contains a progestogen) are used for the second half of the treatment cycle.
Evorel Sequi helps to treat menopausal symptoms such as:
- Osteoporosis
- Hot flushes, night sweats
- Depression, mood swings
- Sleep problems
- Vaginal dryness
NowPatient offers Evorel Sequi patches as a treatment for HRT only, following an online consultation with a prescribing clinician.
Key facts of Evorel Sequi
- For the treatment of HRT
- Evorel Sequi has some common side effects which include nausea and headaches
- Evorel Sequi will not prevent pregnancy in otherwise fertile women
- Do not use a hormonal contraceptive when treated with a HRT
- It can be dangerous if you use Evorel Sequi with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Evorel Sequi not suitable for?
Evorel Sequi may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before using Evorel Sequi if you:
- Are allergic to the active ingredients estradiol or norethisterone acetate
- Have ever had breast cancer
- Have cancer sensitive to oestrogen
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clots
- Suffer from porphyria
- Have had a heart attack, angina, stroke, or high blood pressure
- Have unusual vaginal bleeding
- Have liver disease or any other liver problems
- Are pregnant or breastfeeding
- Have fibroids
- Have uterine problems such as endometriosis or endometrial hyperplasia
- Have diabetes
- Suffer from migraines
- Have gallbladder disease
- Have asthma
- Have epilepsy
- Have fluid retention
- Have high cholesterol levels in the blood
- Are obese
- Have a hereditary ear disorder
How and where to get Evorel Sequi?
You can buy Evorel Sequi safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of HRT, you can discuss if Evorel Sequi is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Evorel Sequi patches for HRT
Evorel Sequi contains 8 patches. 4 Evorel 50 and 4 Evorel Conti patches.
- Evorel 50 patches contain 3.2mg estradiol hemihydrate
- Evorel Conti patches contain 3.2mg estradiol hemihydrate and 11.2mg norethisterone acetate
Information about how to use Evorel Sequi for HRT
The Evorel Sequi patch should be applied to a clean and dry area of skin. You may choose to apply the patch to your thighs or bottom. The patch must be changed twice a week, on the same two days each week. You should not apply the new patch to the same area of skin and do not apply the patch around your breasts. Read the patient information leaflet provided or speak to a healthcare professional for further information.
What happens if you use too much Evorel Sequi?
If you use more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have used too much Evorel Sequi and you experience any of the following side effects:
What are the side effects of Evorel Sequi?
Side effects of Evorel Sequi are split into common and serious.
Common side effects include:
- Nausea
- Headache, dizziness
- Breast tenderness, breast pain
- Change in sex drive
- Anxiety, insomnia
- Stomach pain, indigestion, flatulence, diarrhoea
- Breakthrough bleeding
- Acne, skin irritation, rash
- Vaginal discharge
- Fluid retention, weight gain, bloating
Serious side effects include:
- Blood clots
- Stroke
- Heart disease – chest pain passing into the neck or arm
- Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about using Evorel Sequi at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Evorel Sequi. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:
- Phenytoin or carbamazepine
- Rifampicin
- Ritonavir or nelfinavir
- Warfarin
- St John’s Wort
Can Evorel Sequi used for HRT be used long term?
HRT should only be used as a short-term treatment for the menopause. Women who use HRT for more than 5 years may be at an increased risk of ovarian cancer. Speak to your GP to review your treatment at least once each year and have regular checkups.
Is there a herbal Evorel Sequi?
No. Herbal Evorel Sequi does not exist. If you have been marketed such a formulation, it may be fake.
Should I avoid any particular food or drink when using Evorel Sequi?
You can eat and drink normally when using Evorel Sequi.
What lifestyle changes can I make to help me with HRT?
You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:
- Using a fan
- Cool showers
- Light clothing
- Lubricants
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Evorel Sequi
Alternative HRT patches include Estaderm, Estradot and Evorel Conti patches.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Evorel Sequi
What is Evorel Sequi?
Evorel Sequi is a sequential combined HRT patch system. Each pack contains two types of patches: Evorel 50 (oestradiol 50 mcg/24h only, 4 patches for weeks 1–2) and Evorel Conti (oestradiol 50 mcg + norethisterone 170 mcg/24h, 4 patches for weeks 3–4). This mimics the natural cycle, providing oestrogen-only for the first half and combined oestrogen-progestogen for the second half. It is designed for perimenopausal women with an intact uterus.
How does Evorel Sequi work?
Evorel Sequi delivers oestradiol transdermally throughout the month for symptom relief, with norethisterone added in the second two weeks to induce a regular withdrawal bleed and protect the endometrium. The sequential design makes it appropriate for perimenopausal women or those within 12 months of their last period who still need a monthly bleed. All hormones are delivered through the skin.
How do I use Evorel Sequi patches?
Apply one patch twice weekly. For the first 2 weeks, use Evorel 50 (oestrogen-only) patches. For the next 2 weeks, use Evorel Conti (combined) patches. Each patch is changed every 3–4 days. Apply to clean dry skin on the lower trunk, buttocks, or thigh, rotating the site. A withdrawal bleed usually occurs towards the end of the Evorel Conti phase or just after.
What are the side effects of Evorel Sequi?
Common side effects include application site reactions, breast tenderness, headaches, nausea, and mood changes during the progestogen phase. The withdrawal bleed may cause period-like symptoms. Breakthrough bleeding outside the expected time should be reported to your prescriber. Transdermal delivery means no increased VTE risk compared to oral sequential HRT.
When should I switch from Evorel Sequi to Evorel Conti?
Once you have been postmenopausal for at least 12 months (no natural periods for a year), your prescriber may recommend switching to Evorel Conti for bleed-free HRT. Switching too early may cause irregular bleeding.
How can I get Evorel Sequi?
Evorel Sequi is available on NHS prescription from your GP, menopause clinic, or through NowPatient. It is ideal for perimenopausal women who prefer transdermal HRT delivery.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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