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MEDICAL INFORMATION
Kliovance Key Facts
Other Related Names or Treatments
Evorel, Femoston, Kliofem
About Kliovance
Kliovance tablets contains two active ingredients, estradiol, a natural version of oestrogen and norethisterone, a synthetic progestogen. It is classed as a HRT (hormone replacement therapy), used to treat the symptoms of menopause. Menopausal symptoms include:
- Osteoporosis
- Hot flushes, night sweats
- Depression, mood swings
- Sleep problems
- Vaginal dryness
Kliovance is a combined HRT treatment used in women who are suffering from menopause, but still have a menstrual cycle, and have not had a hysterectomy. If only oestrogen levels are increased during HRT treatment, the endometrium will grow excessively, causing an increased risk of endometrial cancer. Women who have not had a hysterectomy are therefore given HRT that contains progestogen.
NowPatient offers Kliovance as a treatment for HRT only, following an online consultation with a prescribing clinician.
Key facts of Kliovance
- For the treatment of HRT
- Kliovance has some common side effects which include nausea and headaches
- Kliovance will not prevent pregnancy in otherwise fertile women
- Do not use a hormonal contraceptive when treated with a HRT
- It can be dangerous if you take Kliovance with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- Kliovance has a lower dose of oestrogen and progesterone and is more suitable for women who are more sensitive to hormones
Who is Kliovance not suitable for?
Kliovance may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Kliovance if you:
- Have hypersensitivity to the active ingredients estradiol hemihydrate or norethisterone acetate
- Have ever had breast cancer
- Have cancer sensitive to oestrogen
- Have untreated endometrial hyperplasia (an excessively thick womb lining)
- Suffer from a blood clots
- Suffer from porphyria
- Have had a heart attack, angina, stroke, or high blood pressure
- Have unusual vaginal bleeding
- Have liver disease or any other liver problems
- Are pregnant or breastfeeding
- Have fibroids
- Have uterine problems such as endometriosis or endometrial hyperplasia
- Have diabetes
- Suffer from migraines
- Have gallbladder disease
- Have asthma
- Have epilepsy
- Have fluid retention
- Have high cholesterol levels in the blood
- Are obese
- Have a hereditary ear disorder
How and where to get Kliovance?
You can buy Kliovance safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of HRT, you can discuss if Kliovance is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Kliovance for HRT
Kliovance tablets contain 1mg estradiol and 0.5mg norethisterone acetate.
Information about how to take Kliovance for HRT
Kliovance tablets should be taken at the same time each day. Swallow the tablets whole with water, with or without food. Start a new pack once you finish your current pack, without a break.
If you forget to take a tablet, take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Read the patient information leaflet provided or speak to a healthcare professional for further information.
What happens if you take too much Kliovance?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Kliovance and you experience any of the following side effects:
What are the side effects of Kliovance?
Possible side effects of Kliovance are split into common and serious.
Common side effects include:
- Nausea
- Headache, dizziness
- Breast tenderness, breast pain
- Change in sex drive
- Anxiety, insomnia
- Stomach cramps, indigestion, flatulence, diarrhoea
- Breakthrough bleeding
- Acne, skin irritation, rash
- Vaginal discharge
- Fluid retention, weight gain, bloating
- Infection
Serious side effects include:
- Blood clots
- Stroke
- Heart disease – chest pain passing into the neck or arm
- Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Kliovance at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Kliovance. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:
- Phenytoin or carbamazepine
- Rifampicin
- Ritonavir or nelfinavir
- Warfarin
- St John’s Wort
Can Kliovance taken for HRT be taken long term?
HRT should only be used as a short-term treatment for the menopause. Speak to your GP to review your treatment at least once each year and have regular checkups.
Is there a herbal Kliovance?
No. Herbal Kliovance does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Kliovance?
Women can take Kliovance for HRT, but should speak to a doctor if considering taking it while pregnant or breastfeeding.
Should I avoid any particular food or drink when taking Kliovance?
You can eat and drink normally when taking Kliovance.
What lifestyle changes can I make to help me with HRT?
You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:
- Using a fan
- Cool showers
- Light clothing
- Lubricants
- Healthy diet
- Regular exercise
- Quit smoking
Alternatives to Kliovance
Alternative HRT treatments include Femoston, Evorel, and Premarin.
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Kliovance
What is Kliovance?
Kliovance is a continuous combined hormone replacement therapy (HRT) containing oestradiol 1 mg and norethisterone acetate 0.5 mg in every tablet. It is designed to be taken every day without a break, and aims to provide bleed-free HRT for postmenopausal women. Kliovance is suitable for women who are at least 12 months past their last natural period. It is manufactured by Novo Nordisk and available on the NHS.
How does Kliovance work?
Kliovance provides a continuous dose of oestradiol to relieve menopausal symptoms (hot flushes, night sweats, vaginal dryness, mood changes) alongside a continuous low dose of norethisterone to protect the endometrium from thickening. Because the progestogen is given every day (rather than cyclically), the aim is to avoid a monthly withdrawal bleed. This makes it suitable for women who are fully postmenopausal.
What is the difference between Kliovance and Kliofem?
Both are continuous combined HRT products from Novo Nordisk. Kliovance contains oestradiol 1 mg/norethisterone 0.5 mg (lower dose), while Kliofem contains oestradiol 2 mg/norethisterone 1 mg (higher dose). Kliovance is generally tried first as it uses the lowest effective dose. If symptoms are not adequately controlled on Kliovance, your prescriber may switch to Kliofem.
How do I take Kliovance?
Take one tablet daily at the same time, continuously without any break. Each tablet is identical, so there is no specific starting day within the pack. If switching from sequential HRT, start Kliovance after completing the current pack. Swallow the tablet with water, with or without food.
When can I start Kliovance?
Kliovance is suitable for women who are at least 12 months past their last natural period (fully postmenopausal). Starting continuous combined HRT too early may cause irregular breakthrough bleeding. If you are perimenopausal (still having some periods), sequential HRT (such as Elleste Duet or Femoston) is more appropriate initially.
What are the side effects of Kliovance?
Common side effects include breast tenderness, headaches, nausea, bloating, and mood changes. Breakthrough bleeding or spotting may occur in the first 3–6 months, particularly when switching from sequential HRT. If bleeding persists beyond 6 months, your prescriber should investigate. Leg cramps, fluid retention, and skin reactions are uncommon.
Will I have periods on Kliovance?
The aim of continuous combined HRT is to avoid monthly bleeding. Most women on Kliovance will have no periods after the initial settling-in phase. Some spotting or light bleeding may occur in the first 3–6 months, which usually resolves. If bleeding continues or starts after a period of no bleeding, see your prescriber for investigation.
How can I get Kliovance?
Kliovance is available on NHS prescription from your GP, menopause clinic, or through online services like NowPatient. NowPatient offers convenient online consultations with qualified UK prescribers and home delivery.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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