Used for Menopause

Are you tired of high medication costs? Our service offers unbeatable savings on your ACTIVELLA prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Gemini Laboratories, LLC

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

ACTIVELLA cost saving options available to you

  • Qualified

    Rx Advantage Card

    NowPatient's Rx Advantage card is a simple & convenient way to save money on your ACTIVELLA

    You can save up to 90%

  • Available

    Canadian Prescription Savings

    Manufactured by
    Powered by
    Buy your ACTIVELLA without insurance from Canada at discounts of up to 90% using NowPatient's Canadian Prescription savings program.
  • Unavailable

    Drug Coupons

    Obtain your ACTIVELLA for as little as $0 per fill. Suitable for insured individuals only.
  • Unavailable

    Patient Assistance Programs

    Obtain your ACTIVELLA at no cost. Suitable for insured, underinsured and uninsured individuals

How it works

How to Lower Your Drug Costs

  • swoosh
    View programs

    View the savings programs that are available

  • swoosh
    Select program

    Pick the program that is suitable for you

  • swoosh

    If required, complete the online qualification check

  • swoosh
    Start Saving

    Enroll & Start Saving



Why Choose Our Service?

  • black dot icon

    Comprehensive Coverage

    Our service covers a wide range of medications, ensuring you can find savings on almost any prescription.

  • emoji icon

    Easy to Use

    Our website is user-friendly, allowing you to quickly find and apply discounts.

  • check icon

    Trusted by Many

    Thousands of users trust us to help them save on their medication costs every day.


Start Saving Today!

Lower the cost of your ACTIVELLA prescription

Join the many satisfied customers who have already benefited from our prescription discount service.

Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ACTIVELLA Uses, Side Effects, Interactions, Warnings & Dosing



ACTIVELLA is the brand name for estradiol and norethindrone acetate and is available as an oral tablet.

What dosages is ACTIVELLA available in?

What dosages is ACTIVELLA available in?

ACTIVELLA is available as a 1 mg/0.5 mg tablet and a 0.5 mg/0.1 mg tablet.

What is ACTIVELLA used for?

What is ACTIVELLA used for?

ACTIVELLA is a combination of two hormones that are used to treat moderate-to-severe symptoms of menopause, like hot flashes, night sweats, vaginal dryness, irritation, or swelling. It is also used in the prevention of osteoporosis in women who’ve reached menopause.

How does ACTIVELLA work?

How does ACTIVELLA work?

ACTIVELLA is a combination of estradiol and norethindrone which act as natural hormones to balance hormonal changes your body goes through during menopause.

How do I take ACTIVELLA?

How do I take ACTIVELLA?

ACTIVELLA is typically taken once daily.

Is it safe for me to take ACTIVELLA?

Is it safe for me to take ACTIVELLA?

ACTIVELLA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take ACTIVELLA if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

  • Undiagnosed abnormal vaginal bleeding
  • Known, suspected, or history of breast cancer
  • Known or suspected estrogen-dependent cancer
  • Active or history of deep vein thrombosis or pulmonary embolism
  • Stroke or myocardial infarction (heart attack) within the past year
  • Liver disease
  • Allergy to any of the ingredients in Activella
  • Known or suspected pregnancy
ACTIVELLA Common Side Effects

ACTIVELLA Common Side Effects

Common side effects of ACTIVELLA include:

  • Breast pain
  • Headache
  • Accidental injury
  • Upper respiratory tract infection
  • Sinus infection
  • Postmenopausal bleeding
  • Nausea
  • Weight gain
  • Ovarian cyst
  • Stomach flu
  • Viral infection
  • Vaginal yeast infection
  • Mood swings
  • Back pain
ACTIVELLA Serious Side Effects

ACTIVELLA Serious Side Effects

Serious side effects are rare with ACTIVELLA. Contact your healthcare provider immediately if you experience any of the following such as blood clots (trouble breathing, leg pain or swelling, skin that’s warm to the touch); heart attack (chest pain, arm pain, shortness of breath, cold sweats, lightheadedness); stroke (sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache); high calcium levels (tiredness, muscle weakness, nausea, vomiting, constipation); low calcium levels (muscle spasms or twitching, numbness and tingling in your fingers, toes, or around your mouth); or unusual vaginal bleeding, vaginal discharge, or pelvic pain.

Effects of other drugs, drug classes and over-the-counter products on ACTIVELLA

Effects of other drugs, drug classes and over-the-counter products on ACTIVELLA

The following medications may interact with ACTIVELLA:

  • Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of ACTIVELLA
  • Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of ACTIVELLA
Who makes ACTIVELLA?

Who makes ACTIVELLA?

Gemini Laboratories, LLC

Is ACTIVELLA safe in pregnancy?

Is ACTIVELLA safe in pregnancy?

ACTIVELLA should not be used during pregnancy.


What to do if you missed your ACTIVELLA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
dollar sign

Drug Savings Tips

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

FAQ logo

Things to know

Now Patient Data Security

Data Security

Our Commitment to You.

Find out moreNow Patient Data SecurityNow Patient Data Security

What is NowPatient

Online Pharmacy & Telehealth

NowPatient is an online pharmacy & telehealth service that is available in the US and UK. Our service is FREE and packed with useful features that can help you save money on the cost of your medications, access virtual treatments, and provide tools that can help improve your overall health.  Get started today and benefit from medication reminders, private treatment plans, NHS online pharmacy, GP appointment booking, Rx savings card, Drug Coupons, US drug savings programs, health conditions information, Drug Information, genetic testing, home test kits, BMI Risks, Type 2 Diabetes Riskspollen meter, air quality monitor, and lots more!

A laptop screen displays a dashboard with various health metrics and notifications. Widgets include drug coupons, home health testing, genetic risk, diabetes risk, BMI, pollen meter, and air quality.


To improve the lives of everyone by making high-quality care accessible and convenient

We are here to improve lives. Our service gives you access to smart features and resources that can help empower you to take control of your health and improve your health outcomes. All this, in one place, for FREE. We strive to bring a fresh perspective to managing health. NowPatient can be accessed by downloading the App or using your web browser.

Download our app today

A collage showing a map with pharmacies, a questionnaire, medication details, and a person video chatting on a screen.

Can I trust NowPatient

Meet our medical team

We are a passionate group of clinicians and medical writers covering a broad range of specialities with experience operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process

Your Questions Answered

For your peace of mind, we can answer your questions quickly

We have a comprehensive list of FAQ’s on each feature page. Alternatively, for broader questions around our service just click the button below.
Find your answers