ACTIVELLA

Activella (estradiol/norethindrone) is a combined medication comprising estradiol and norethindrone, effectively alleviating symptoms associated with low estrogen levels in menopause, such as hot flashes, night sweats, and vaginal dryness.

If conventional methods like exercise, calorie reduction, and a balanced diet have proven ineffective in your weight loss efforts, hormone replacement therapy (HRT) could be a viable solution. HRT may be particularly beneficial for weight loss if you experienced weight gain during menopause or have excess abdominal fat.

North American Menopause Society 2022: “Routine discontinuation of hormone therapy is not necessary for women aged over 60 or 65 years and can be contemplated for continuation beyond age 65, especially for persistent vasomotor symptoms (VMS).”

Estradiol controls body weight by reducing appetite and enhancing sensations of satiety.

Hot flushes, nocturnal sweats, sleep disturbances resulting from menopause, anxiety, low mood attributed to menopause, and vaginal dryness.

The combination of estradiol and norethindrone is used to alleviate moderate to severe menopausal symptoms such as sensations of warmth in the face, neck, and chest, sudden intense episodes of heat and sweating (hot flashes), and vaginal issues. Additionally, this medication is utilized to prevent osteoporosis after menopause.

Every film-coated Activelle tablet comprises 1 mg of estradiol (as estradiol hemihydrate) and 0.5 mg of norethisterone acetate. Inactive ingredients in the tablet core include lactose monohydrate, maize starch, copovidone, talc, and magnesium stearate. The film-coating consists of hypromellose, triacetin, and talc.

The use of this medication may elevate the likelihood of blood clots, stroke, or heart attack. The risk is further heightened for individuals with conditions such as high blood pressure, diabetes, high cholesterol, those who are overweight, or individuals who smoke.

Administer Activella (estradiol and norethindrone tablets) at the same time each day, with or without food. If it causes an upset stomach, take it with food.

Both drugs are effective for their licensed indications. Your doctor will discuss which medication is the most suitable considering your health circumstances and condition which is being treated.

Activella is a tablet that combines estrogen and progestin as part of hormone replacement therapy (HRT).

Opting for estrogen in the form of a patch, gel, or spray is considered safer, as it is absorbed directly through the skin, resulting in fewer side effects and risks.

It took approximately three weeks to take effect, but it is effective.

A comprehensive analysis of 22 well-executed randomized clinical trials found no significant difference in weight between menopausal women undergoing hormone replacement therapy (HRT) and those who were not treated.

Frequent side effects of estradiol and norethindrone can include nausea, vomiting, bloating, stomach cramps, and fluid retention, manifesting as swelling and rapid weight gain.

If you struggle with swallowing tablets or are prone to forgetting doses, patches may present a preferable option. The use of patches can also minimize certain side effects associated with hormone replacement therapy (HRT), like indigestion. Notably, unlike tablets, they do not elevate the risk of blood clots.

Consume this medication with a meal. Refrain from eating grapefruit or drinking grapefruit juice while using this medicine, as they can alter the absorption of the medication in the body.

If you have any inquiries, consult your doctor or pharmacist. Take this medication orally, with or without food, according to your doctor’s instructions, typically once a day. You can take it with food or immediately after a meal to reduce the risk of stomach upset. The prescribed dosage depends on your medical condition and how you respond to the treatment.

Herbal medicine involves using plants or plant extracts, such as evening primrose oil or St. John’s Wort, to alleviate symptoms. Alternative medicine encompasses various therapies used as alternatives to conventional medicine, including acupressure, acupuncture, and homeopathy.

Tablets, intended for oral ingestion. A skin patch that adheres to your skin. An implant, administered under local anesthesia. Oestrogen gel, applied to the skin and absorbed. Oestrogen spray, applied to the forearm.

Across extensive studies spanning the past 15 years, and in addition to other research, minimal or no evidence has been discovered supporting the notion that Hormone Replacement Therapy (HRT) diminishes the risk of heart disease. Conversely, these studies have identified indications of an elevated risk of blood clots and stroke associated with HRT. Moreover, an augmented risk of breast and ovarian cancer has been observed in women undergoing HRT.

Possible side effects like stomach upset, nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, promptly inform your doctor or pharmacist.

Abdominal pain, breast lumps, breast pain, alterations in vaginal discharge, skin and mucous membrane discoloration, nipple discharge, and increased or prolonged and exceptionally heavy periods.

Extended usage increases the risk of the following side effects: ovarian cancer, endometrial cancer, breast cancer, endometrial hyperplasia, or thickening of the womb lining. Additionally, chest pain may occur.

Hot flushes, nocturnal sweats, sleep disturbances resulting from menopause, anxiety, low mood attributed to menopause, and vaginal dryness.

Contraindications for Activella include undiagnosed abnormal genital bleeding, breast or other estrogen-dependent tumors, thromboembolic disorders such as deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, and myocardial infarction (MI). Additionally, individuals with protein C, protein S, or antithrombin deficiency, or other thrombophilias should avoid Activella.

The use of this medication may elevate your likelihood of developing blood clots, experiencing strokes, or suffering from heart attacks. This risk may persist even after discontinuing the medication.

Hormone replacement therapy (HRT) comes with potential risks, which encompass the development of breast cancer and cardiovascular disease, affecting the heart and blood vessels.

Indications of liver issues may include symptoms such as nausea, vomiting, diarrhea, reduced appetite, weight loss, yellowing of the skin or eyes, dark urine, and pale stools.

Current research indicates that menopausal women undergoing hormone therapy typically exhibit reduced body fat, particularly in the visceral belly region. The distribution of body fat is influenced by estrogen, and diminished estrogen levels can contribute to an accumulation of fat in the abdominal area.

Indeed, hormone replacement therapy (HRT) has the potential to inhibit the accumulation of abdominal fat. HRT is also expected to enhance sleep quality and alleviate other menopausal symptoms, consequently providing increased energy and motivation to engage in healthy eating and exercise. One actionable step is to consume smaller portions, recognizing that our dietary needs may have changed.

There is no evidence supporting the direct correlation between hormone replacement therapy (HRT) and weight loss. While HRT is not classified as a weight loss medication, many women, upon experiencing significant improvement in well-being, find renewed desire and motivation to prioritize self-care. This often translates into healthier food choices, incorporating more fruits, vegetables, and higher fiber into their diets.

Numerous individuals assert that fluctuations in estrogen levels impact their weight, especially during menopause. A decline in estradiol, a type of estrogen hormone, can potentially result in weight gain or pose challenges in losing weight.

Consume calories through nutritious sources like fruits and vegetables, avoiding sweets, alcohol, or white bread. Limit alcohol intake. Incorporate physical activity into your routine, aiming for at least an hour of exercise on four days each week, or more if feasible.

Administer this medication orally, with or without food, according to your doctor’s instructions, typically once daily. To prevent stomach upset, you can take it with food or immediately after a meal. The prescribed dosage is determined by your medical condition and how you respond to treatment. Consistently take this medication to derive the maximum benefit from it.

Sudden increase in body weight, indications of depression (such as impaired concentration, alterations in weight, changes in sleep patterns, diminished interest in activities, and thoughts of suicide), and indications of liver issues (like nausea, vomiting, diarrhea, reduced appetite, weight loss, yellowing of the skin or eyes, dark urine, and pale stools).

Adopt a consistent exercise regimen. Incorporate fiber into your diet. Consume vegetables from the cruciferous family. Minimize your exposure to endocrine disruptors.

We often seek instant results, but the advantages of hormone replacement therapy (HRT) require some patience. Although some individuals experience enhanced sleep or mood shortly after beginning HRT, notable changes such as improved muscle mass or fat loss may take at least three to six months.