estradiol
Used for Menopause
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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estradiol Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is estradiol available in?
estradiol is available as a 0.5 mg, 1 mg, or 2 mg tablet and a 0.01% vaginal cream.
What is estradiol used for?
estradiol is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.
How does estradiol work?
estradiol replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.
How do I take estradiol?
estradiol tablets are typically taken once daily. estradiol cream is typically applied to the vagina daily for 1 to 2 weeks then slowly lowered to 1 gram one to three times a week.
Is it safe for me to take estradiol?
estradiol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take estradiol if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:
- Undiagnosed abnormal vaginal bleeding
- Known, suspected, or history of breast cancer
- Known or suspected estrogen-dependent cancer
- Active or history of deep vein thrombosis or pulmonary embolism
- Stroke or myocardial infarction (heart attack) within the past year
- Liver disease
- Allergy to any of the ingredients in Activella
- Known or suspected pregnancy
estradiol Common Side Effects
Common side effects of estradiol include:
- Headache
- Breast pain or tenderness
- Flu-like symptoms
- Stomach pain
- Swelling
- Back and body pain
- Depression
- Vaginal spotting
- Upset stomach
- Weight gain
- Rashes
- Vaginal discharge
- Itching
- Nausea
estradiol Serious Side Effects
Serious side effects are rare with estradiol. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions
- Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
- Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
- Shortness of breath
- Breast lumps or pain
- Unusual or heavy vaginal bleeding
- Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)
Effects of other drugs, drug classes and over-the-counter products on estradiol
The following medications may interact with estradiol:
- Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of DOTTI
- Inhibitors of CYP3A4 such as erythromycin, clarithromycin
- ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of estradiol
Who makes estradiol?
Various FDA-approved generic manufacturers
Is estradiol safe in pregnancy?
estradiol should not be used during pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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