estradiol
Used for Menopause
NowPatient helps you obtain your estradiol prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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Lower the cost of your estradiol prescription
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estradiol key facts
What dosages is estradiol available in?
estradiol is available as a 0.5 mg, 1 mg, or 2 mg tablet and a 0.01% vaginal cream.
What is estradiol used for?
estradiol is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.
How does estradiol work?
estradiol replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.
How do I take estradiol?
estradiol tablets are typically taken once daily. estradiol cream is typically applied to the vagina daily for 1 to 2 weeks then slowly lowered to 1 gram one to three times a week.
Is it safe for me to take estradiol?
estradiol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take estradiol if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:
- Undiagnosed abnormal vaginal bleeding
- Known, suspected, or history of breast cancer
- Known or suspected estrogen-dependent cancer
- Active or history of deep vein thrombosis or pulmonary embolism
- Stroke or myocardial infarction (heart attack) within the past year
- Liver disease
- Allergy to any of the ingredients in Activella
- Known or suspected pregnancy
estradiol Common Side Effects
Common side effects of estradiol include:
- Headache
- Breast pain or tenderness
- Flu-like symptoms
- Stomach pain
- Swelling
- Back and body pain
- Depression
- Vaginal spotting
- Upset stomach
- Weight gain
- Rashes
- Vaginal discharge
- Itching
- Nausea
estradiol Serious Side Effects
Serious side effects are rare with estradiol. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions
- Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
- Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
- Shortness of breath
- Breast lumps or pain
- Unusual or heavy vaginal bleeding
- Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)
Effects of other drugs, drug classes and over-the-counter products on estradiol
The following medications may interact with estradiol:
- Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of DOTTI
- Inhibitors of CYP3A4 such as erythromycin, clarithromycin
- ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of estradiol
Who makes estradiol?
Various FDA-approved generic manufacturers
Is estradiol safe in pregnancy?
estradiol should not be used during pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my estradiol prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your estradiol prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient estradiol savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient estradiol savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for estradiol | Canadian Prescription Savings* for estradiol | estradiol Drug Coupon* | estradiol Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of estradiol?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for estradiol | Canadian Prescription Savings* for estradiol | estradiol Drug Coupon* | estradiol Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the estradiol savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the estradiol drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for estradiol, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the estradiol prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, estradiol is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed estradiol for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the estradiol prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the estradiol prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for estradiol
If you are having trouble paying for your estradiol medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for estradiol you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- estradiol is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers estradiol
- If estradiol is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for estradiol
If you are having trouble paying for your estradiol medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for estradiol you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers estradiol
- If estradiol is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for estradiol
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your estradiol treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for estradiol you will need to meet the following criteria:
- You must be currently insured and have coverage for estradiol
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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