Question 1

How can I lower the cost of my estradiol

Accepted Answer

You can lower cost of your estradiol using one of the 4 following drug savings programs: Rx Advantage Card for estradiol, Canadian Prescription Savings for estradiol, estradiol Drug Coupons, estradiol Patient Assistance Programs

Question 2

What dosages is estradiol available in?

Accepted Answer

estradiol is available as a 0.5 mg, 1 mg, or 2 mg tablet and a 0.01% vaginal cream.

Question 3

What is estradiol used for?

Accepted Answer

estradiol is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

Question 4

How does estradiol work?

Accepted Answer

estradiol replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

Question 5

How do I take estradiol?

Accepted Answer

estradiol tablets are typically taken once daily. estradiol cream is typically applied to the vagina daily for 1 to 2 weeks then slowly lowered to 1 gram one to three times a week.

Question 6

Is it safe for me to take estradiol?

Accepted Answer

estradiol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take estradiol if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:  Undiagnosed abnormal vaginal bleeding Known, suspected, or history of breast cancer Known or suspected estrogen-dependent cancer Active or history of deep vein thrombosis or pulmonary embolism Stroke or myocardial infarction (heart attack) within the past year Liver disease Allergy to any of the ingredients in Activella Known or suspected pregnancy

Question 7

estradiol Common Side Effects

Accepted Answer

Common side effects of estradiol include:  Headache Breast pain or tenderness Flu-like symptoms Stomach pain Swelling Back and body pain Depression Vaginal spotting Upset stomach Weight gain Rashes Vaginal discharge Itching Nausea

Question 8

estradiol Serious Side Effects

Accepted Answer

Serious side effects are rare with estradiol. Contact your healthcare provider immediately if you experience any of the following.  Allergic reactions Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw) Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches) Shortness of breath Breast lumps or pain Unusual or heavy vaginal bleeding Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)

Question 9

Effects of other drugs, drug classes and over-the-counter products on estradiol

Accepted Answer

The following medications may interact with estradiol:  Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of DOTTI Inhibitors of CYP3A4 such as erythromycin, clarithromycin ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of estradiol

Question 10

Who makes estradiol?

Accepted Answer

Various FDA-approved generic manufacturers

Question 11

Is estradiol safe in pregnancy?

Accepted Answer

estradiol should not be used during pregnancy.

Question 12

What is the brand name for estradiol?

Accepted Answer

ESTRACEVAGIFEMACTIVELLADOTTIVIVELLE-DOTCLIMARA

Question 13

How can NowPatient help me to lower the cost of my estradiol prescription?

Accepted Answer

After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your estradiol prescription

Applicability to each program will be dependent on your insurance status.

Question 14

How do the NowPatient estradiol savings programs work?

Accepted Answer

After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.

Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.

Question 15

Are the NowPatient estradiol savings programs suitable for everyone, regardless of insurance status?

Accepted Answer

No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.

	Rx Advantage Card* for estradiol	Canadian Prescription Savings* for estradiol	estradiol Drug Coupon*	estradiol Patient Assistance Program*
Insured (federal, state or government)	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured (Commercial or Private)	Available	Available	Available If Offered by Pharmaceutical Company	Available If Offered by Pharmaceutical Company
Uninsured	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured but without pharmacy benefit or drug coverage	Available	Available	Not Available	Available If Offered by Pharmaceutical Company

*This is not insurance.

Question 16

Are the NowPatient drug savings programs suitable for brand and generic versions of estradiol?

Accepted Answer

No. Each program has applicability requirements. Please see below

	Rx Advantage Card* for estradiol	Canadian Prescription Savings* for estradiol	estradiol Drug Coupon*	estradiol Patient Assistance Program*
Brand	Yes	Yes	Yes, If Offered by Pharmaceutical Company	Yes, If Offered by Pharmaceutical Company
Generic	Yes	Yes	No	No

*This is not insurance.

Question 17

If you have Medicare Part D or Medicare Advantage and none of the estradiol savings options are applicable or affordable for me, what can you do?

Accepted Answer

If you are insured with Medicare and the estradiol drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.

The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.

If you are denied Medicaid for estradiol, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

Question 18

I am uninsured or underinsured and none of the estradiol prescription saving options are applicable or affordable for me, what can I do?

Accepted Answer

If you are uninsured or underinsured (for example, estradiol is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.

The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

If you are denied and all else fails, and if you have been prescribed estradiol for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.

Question 19

I am commercially or privately insured and none of the estradiol prescription saving options are applicable or affordable for me, what can I do?

Accepted Answer

If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.

If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.

However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.

The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.

Question 20

If I have federal, state or commercial insurance and none of the estradiol prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?

Accepted Answer

If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:

1. Patient Access Network Foundation (PAN) assistance for estradiol

If you are having trouble paying for your estradiol medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for estradiol you will need to meet one or all of the following criteria:

Your income is below 400% of the federal poverty level
estradiol is prescribed for an approved FDA indication
You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
You have Medicare insurance coverage that covers estradiol
If estradiol is listed on PAN’s list of covered medications

You can check the Patient Access Network Foundation Website for more information.

2. HealthWell Foundation Copay Program for estradiol

If you are having trouble paying for your estradiol medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for estradiol you will need to meet the following criteria:

You live in and are being treated in the United States
You are insured and your plan covers estradiol
If estradiol is listed on the HealthWell Foundation’s list of covered medications

You can check the HealthWell Foundation Website for more information.

3. Patient Advocate Foundation Co-Pay Relief Program for estradiol

Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your estradiol treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for estradiol you will need to meet the following criteria:

You must be currently insured and have coverage for estradiol
You must have a confirmed diagnosis and treatment plan
You must reside and receive treatment in the United States
Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.