EstradiolPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
    You save
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  2. Estradiol (Twice Weekly)
    Generic for Dotti
    8 Patches patchs $48.81 USD
    Save $47.27
  3. Estradiol (Twice Weekly)
    Generic for Dotti
    8 Patches patchs $48.81 USD
    Save $47.27
  4. Estradiol (Twice Weekly)
    Generic for Dotti
    8 Patches patchs $48.81 USD
    Save $47.27
  5. Estradiol (Twice Weekly)
    Generic for Dotti
    8 Patches patchs $44.17 USD
    Save $51.91
  6. Estradiol Vaginal Estrogen Cream
    Generic for Estrace
    42.5g tube of creams $20.48 USD
    Save $204.53
  7. Estradiol / Norethrindrone Acetate
    Generic for Activella
    28 blister pack of tabletss $26.23 USD
    Save $83.16
  8. Estradiol / Norethrindrone Acetate
    Generic for Activella
    28 blister pack of tabletss $36.25 USD
    Save $73.14
  9. Estradiol (Once Weekly)
    Generic for Climara
    4 Patches patchs $54.34 USD
    Save $48.24
  10. Estradiol (Twice Weekly)
    Generic for Vivelle-Dot
    8 patchs $50.84 USD
    Save $135.03
  11. Estradiol Vaginal Estrogen
    Generic for Vagifem
    Estradiol Vaginal Estrogen
    30 tablets $111.9 USD
    Save $457.20
  12. Estradiol Oral Estrogen
    Generic for Estrace
    Estradiol Oral Estrogen
    30 tablets $5.1 USD
    Save $6.30
  13. Estradiol Oral Estrogen
    Generic for Estrace
    Estradiol Oral Estrogen
    30 tablets $5.1 USD
    Save $6.30
  14. Estradiol Oral Estrogen
    Generic for Estrace
    Estradiol Oral Estrogen
    60 tablets $5.7 USD
    Save $17.10
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Do you need a prescription for estradiol?

Yes, estradiol is only available with a valid physician Rx.

How much is estradiol without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase estradiol, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for estradiol in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a estradiol savings card?

Yes. Save up to 90% on your estradiol with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a estradiol coupon provider in the US?

No. Now Patient does not provide estradiol coupons or FREE estradiol samples.

Do you accept commercial, Medicare or Medicaid coverage for estradiol in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much estradiol?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using estradiol. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much estradiol. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic estradiol?

Generic estradiol refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of estradiol

Estradiol is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions related to hormonal imbalance, such as menopausal symptoms, hormone replacement therapy, and certain gynecological disorders.

Active ingredient of estradiol

The active ingredient of estradiol is estradiol, which is a form of the hormone estrogen.

US brand name of estradiol and manufacturer

Estradiol is available under various brand names in the US, including Estrace, Climara, and Vivelle-Dot. These medications are manufactured by different pharmaceutical companies.

UK brand name of estradiol and manufacturer

In the UK, estradiol is available under various brand names, and the manufacturers may vary.

Prescription requirement for estradiol

A prescription (Rx) is required for estradiol in both the US and the UK.

Availability of estradiol in the UK with NHS prescription

Estradiol is available in the UK with an NHS prescription.

Conditions treated by estradiol

Estradiol is a hormone normally made by the ovaries in the human body. Estardiol therapy is used to reduce symptoms of menopause such as hot flashes, vaginal dryness, and to prevent osteoporosis related to low estrogen levels or hormonal imbalance due to ovarian failure. Estardiol may also be used for the treatment of prostate cancer in men.

How does estradiol work?

Estradiol works by supplementing or replacing the estrogen hormone in the body. It helps to alleviate menopausal symptoms, restore hormonal balance, and provide therapeutic benefits in specific gynecological conditions.

Forms of estradiol available

Estradiol is available in various forms, including oral tablets, transdermal patches, topical gels, creams, vaginal rings, and injectable formulations.

Dosage of estradiol

The dosage of estradiol may vary depending on the specific condition being treated, the route of administration, and individual patient factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for estradiol use

Estradiol should be taken or used as directed by the healthcare provider, following the specific instructions for the chosen form of medication (e.g., oral ingestion, patch application, vaginal insertion).

Warnings and precautions for estradiol

  • Estradiol should not be used in individuals with a history of certain medical conditions, such as breast cancer, uterine cancer, or blood clots
  • Postmenopausal women taking estrogen with progestin are at an increased risk for breast cancer
  • Long-term use of estrogen therapy may be associated with increased risks of certain health conditions, including cardiovascular events, breast cancer, and endometrial cancer
  • Tell your doctor if you have undiagnosed vaginal bleeding, liver disease, kidney disease, heart disease (such as heart attack), angioedema, blood clotting disorders, high blood pressure, high cholesterol levels, obesity, underactive thyroid, high or low blood calcium levels, fibroids, endometriosis, gallbladder disease, seizures, asthma, migraine headaches, or depression before you use estradiol

Use of estradiol during pregnancy

Estradiol is not indicated for use during pregnancy. It should be avoided unless specifically prescribed by a healthcare provider. The potential risks and benefits should be discussed.

Use of estradiol while breastfeeding

Estradiol is not recommended during breastfeeding, as it can pass into breast milk and may have effects on the nursing infant. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Possible side effects of estradiol

Common side effects of estradiol may include breast tenderness, bloating, weight gain, mood changes, headache, and nausea. Serious side effects are rare but can include cardiovascular events, blood clots, and certain types of cancers. Get medical help right away if you have an allergic reaction. Symptoms include hives, trouble breathing, swelling of your face, tongue or throat, skin rash, and blistering or peeling of the skin. Promptly report any adverse effects to a healthcare provider.

Interactions with other drugs

Estradiol may interact with certain medications. Be sure to tell your doctor if you are using contraceptives or hormone replacement therapy. It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter (OTC) drugs, dietary supplements, multivitamins, and herbal products, to avoid any adverse effects and potential drug interactions.

Similar drugs to estradiol

Other estrogen hormone replacement therapies similar to estradiol include estrone and estriol.


  • FDA Prescribing Information for Estradiol
  • MHRA product information for Estradiol
  • NHS UK
  • Drugs.com
  • WebMD


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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