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Estradiol is available as a 1 mg/0.5 mg tablet and a 0.5 mg/0.1 mg tablet.

Estradiol is a combination of two hormones that are used to treat moderate-to-severe symptoms of menopause, like hot flashes, night sweats, vaginal dryness, irritation, or swelling. It is also used in the prevention of osteoporosis in women who’ve reached menopause.

Estradiol is a combination of Estradiol and norethindrone which act as natural hormones to balance hormonal changes your body goes through during menopause.

Estradiol is typically taken once daily.

Estradiol is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Estradiol if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

• Undiagnosed abnormal vaginal bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent cancer
• Active or history of deep vein thrombosis or pulmonary embolism
• Stroke or myocardial infarction (heart attack) within the past year
• Liver disease
• Allergy to any of the ingredients in Estradiol
• Known or suspected pregnancy

Common side effects of Estradiol include:

• Breast pain
• Headache
• Accidental injury
• Upper respiratory tract infection
• Sinus infection
• Postmenopausal bleeding
• Nausea
• Weight gain
• Ovarian cyst
• Stomach flu
• Viral infection
• Vaginal yeast infection
• Mood swings
• Back pain

Serious side effects are rare with Estradiol. Contact your healthcare provider immediately if you experience any of the following such as blood clots (trouble breathing, leg pain or swelling, skin that’s warm to the touch); heart attack (chest pain, arm pain, shortness of breath, cold sweats, lightheadedness); stroke (sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache); high calcium levels (tiredness, muscle weakness, nausea, vomiting, constipation); low calcium levels (muscle spasms or twitching, numbness and tingling in your fingers, toes, or around your mouth); or unusual vaginal bleeding, vaginal discharge, or pelvic pain.

The following medications may interact with Estradiol:

• Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of Estradiol
• Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of Estradiol

Various FDA-approved generic manufacturers

Estradiol should not be used during pregnancy.

• Activella
• Climara
• Dotti
• Estrace
• Evorel
• Vagifem
• Vivelle-DOT