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Vagifem is the brand name for estradiol and is available as a vaginal insert.

Vagifem is available as a 10 mcg vaginal insert.

Vagifem is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

Vagifem replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

Vagifem is dosed as follows: 1 insert into the vagina once a day for 2 weeks. After that, place 1 insert into the vagina twice a week (for example, Tuesday and Friday).

Vagifem is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Vagifem if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

• Undiagnosed abnormal vaginal bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent cancer
• Active or history of deep vein thrombosis or pulmonary embolism
• Stroke or myocardial infarction (heart attack) within the past year
• Liver disease
• Allergy to any of the ingredients in Activella
• Known or suspected pregnancy

Common side effects of Vagifem include:

• Vaginal yeast infections
• Itching of the vagina or vulva area
• Back pain
• Diarrhea

Serious side effects are rare with Vagifem. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat
• Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
• Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face, sudden, severe headache
• Blood clots: legs (cramps, swelling, pain, muscle tightness) and lungs (shortness of breath, trouble breathing, chest pain, cough)
• Breast lumps or pain
• Unusual vaginal bleeding

The following medications may interact with Vagifem:

• Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of Vagifem
• Inhibitors of CYP3A4 such as erythromycin, clarithromycin
• ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of Vagifem

Bayer HealthCare Pharmaceuticals Inc.

Vagifem should not be used during pregnancy.

• Estradiol