Used for Menopause

View VIVELLE-DOT savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or VIVELLE-DOT Patient Assistance Program.

Programs are suitable for individuals who want to buy VIVELLE-DOT without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Novartis Pharmaceuticals

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about VIVELLE-DOT



VIVELLE-DOT is the brand name for estradiol and is available as a transdermal patch.

What dosages is VIVELLE-DOT available in?

What dosages is VIVELLE-DOT available in?

VIVELLE-DOT is available as a transdermal patch that delivers 0.025 mg, 0.0375 mg, 0.05 mg, 0.06 mg, 0.075 mg, and 0.1 mg of estradiol per day.

What is VIVELLE-DOT used for?

What is VIVELLE-DOT used for?

VIVELLE-DOT is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

How does VIVELLE-DOT work?

How does VIVELLE-DOT work?

VIVELLE-DOT replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

How do I take VIVELLE-DOT?

How do I take VIVELLE-DOT?

The starting dose of VIVELLE-DOT is started low and then increased as needed. It is a patch that is placed on the lower part of the stomach or upper part of the buttocks and replaced twice weekly.

Is it safe for me to take VIVELLE-DOT?

Is it safe for me to take VIVELLE-DOT?

VIVELLE-DOT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take VIVELLE-DOT if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

  • Undiagnosed abnormal vaginal bleeding
  • Known, suspected, or history of breast cancer
  • Known or suspected estrogen-dependent cancer
  • Active or history of deep vein thrombosis or pulmonary embolism
  • Stroke or myocardial infarction (heart attack) within the past year
  • Liver disease
  • Allergy to any of the ingredients in Activella
  • Known or suspected pregnancy
VIVELLE-DOT Common Side Effects

VIVELLE-DOT Common Side Effects

Common side effects of VIVELLE-DOT include:

  • Headache
  • Breast pain or tenderness
  • Flu-like symptoms
  • Stomach pain
  • Swelling
  • Back and body pain
  • Depression
  • Vaginal spotting
  • Upset stomach
  • Weight gain
  • Rashes
  • Vaginal discharge
  • Itching
  • Nausea
VIVELLE-DOT Serious Side Effects

VIVELLE-DOT Serious Side Effects

Serious side effects are rare with VIVELLE-DOT. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions
  • Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
  • Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
  • Shortness of breath
  • Breast lumps or pain
  • Unusual or heavy vaginal bleeding
  • Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)
Effects of other drugs, drug classes and over-the-counter products on VIVELLE-DOT

Effects of other drugs, drug classes and over-the-counter products on VIVELLE-DOT

The following medications may interact with VIVELLE-DOT:

  • Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of VIVELLE-DOT
  • Inhibitors of CYP3A4 such as erythromycin, clarithromycin
  • ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of VIVELLE-DOT
Who makes VIVELLE-DOT?

Who makes VIVELLE-DOT?

Novartis Pharmaceuticals

Is VIVELLE-DOT safe in pregnancy?

Is VIVELLE-DOT safe in pregnancy?

VIVELLE-DOT should not be used during pregnancy.


What to do if you missed your VIVELLE-DOT dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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