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Dotti is the brand name for estradiol and is available as a transdermal patch.

Dotti is available as a transdermal patch that delivers 0.025 mg, 0.0375 mg, 0.05 mg, 0.06 mg, 0.075 mg, and 0.1 mg of estradiol per day.

Dotti is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

Dotti replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

The starting dose of Dotti is started low and then increased as needed. It is a patch that is placed on the lower part of the stomach or upper part of the buttocks and replaced twice weekly.

Dotti is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take Dotti if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

• Undiagnosed abnormal vaginal bleeding
• Known, suspected, or history of breast cancer
• Known or suspected estrogen-dependent cancer
• Active or history of deep vein thrombosis or pulmonary embolism
• Stroke or myocardial infarction (heart attack) within the past year
• Liver disease
• Allergy to any of the ingredients in Activella
• Known or suspected pregnancy

Common side effects of Dotti include:

• Headache
• Breast pain or tenderness
• Flu-like symptoms
• Stomach pain
• Swelling
• Back and body pain
• Depression
• Vaginal spotting
• Upset stomach
• Weight gain
• Rashes
• Vaginal discharge
• Itching
• Nausea

Serious side effects are rare with Dotti. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reactions
• Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
• Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
• Shortness of breath
• Breast lumps or pain
• Unusual or heavy vaginal bleeding
• Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)

The following medications may interact with Dotti:

• Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of Dotti
• Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of Dotti

Amneal Pharmaceuticals

Dotti should not be used during pregnancy.

• Estradiol