Used for Menopause

View DOTTI savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or DOTTI Patient Assistance Program.

Programs are suitable for individuals who want to buy DOTTI without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Amneal Pharmaceuticals LLC

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about DOTTI

What is DOTTI?

What is DOTTI?

DOTTI is the brand name for estradiol and is available as a transdermal patch.

What dosages is DOTTI available in?

What dosages is DOTTI available in?

DOTTI is available as a transdermal patch that delivers 0.025 mg, 0.0375 mg, 0.05 mg, 0.06 mg, 0.075 mg, and 0.1 mg of estradiol per day.

What is DOTTI used for?

What is DOTTI used for?

DOTTI is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

How does DOTTI work?

How does DOTTI work?

DOTTI replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

How do I take DOTTI?

How do I take DOTTI?

The starting dose of DOTTI is started low and then increased as needed. It is a patch that is placed on the lower part of the stomach or upper part of the buttocks and replaced twice weekly.

Is it safe for me to take DOTTI?

Is it safe for me to take DOTTI?

DOTTI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take DOTTI if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

  • Undiagnosed abnormal vaginal bleeding
  • Known, suspected, or history of breast cancer
  • Known or suspected estrogen-dependent cancer
  • Active or history of deep vein thrombosis or pulmonary embolism
  • Stroke or myocardial infarction (heart attack) within the past year
  • Liver disease
  • Allergy to any of the ingredients in Activella
  • Known or suspected pregnancy
DOTTI Common Side Effects

DOTTI Common Side Effects

Common side effects of DOTTI include:

  • Headache
  • Breast pain or tenderness
  • Flu-like symptoms
  • Stomach pain
  • Swelling
  • Back and body pain
  • Depression
  • Vaginal spotting
  • Upset stomach
  • Weight gain
  • Rashes
  • Vaginal discharge
  • Itching
  • Nausea
DOTTI Serious Side Effects

DOTTI Serious Side Effects

Serious side effects are rare with DOTTI. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions
  • Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
  • Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
  • Shortness of breath
  • Breast lumps or pain
  • Unusual or heavy vaginal bleeding
  • Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)
Effects of other drugs, drug classes and over-the-counter products on DOTTI

Effects of other drugs, drug classes and over-the-counter products on DOTTI

The following medications may interact with DOTTI:

  • Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of DOTTI
  • Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of DOTTI
Who makes DOTTI?

Who makes DOTTI?

Amneal Pharmaceuticals LLC

Is DOTTI safe in pregnancy?

Is DOTTI safe in pregnancy?

DOTTI should not be used during pregnancy.


What to do if you missed your DOTTI dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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