How can I lower the cost of my DOTTI

You can lower cost of your DOTTI using one of the 4 following drug savings programs: Rx Advantage Card for DOTTI, Canadian Prescription Savings for DOTTI, DOTTI Drug Coupons, DOTTI Patient Assistance Programs

DOTTI Coupon, Savings Card and Patient Assistance

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DOTTI

Used for Menopause

Are you tired of high medication costs? Our service offers unbeatable savings on your DOTTI prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.

Manufactured by Amneal Pharmaceuticals LLC

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

This content is intended for US audiences only

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DOTTI Uses, Side Effects, Interactions, Warnings & Dosing

Medically reviewed by Jamie Winn, Pharm.D

Written by Rajive Patel, B.Pharm

What is DOTTI?

DOTTI is the brand name for estradiol and is available as a transdermal patch.

What dosages is DOTTI available in?

DOTTI is available as a transdermal patch that delivers 0.025 mg, 0.0375 mg, 0.05 mg, 0.06 mg, 0.075 mg, and 0.1 mg of estradiol per day.

What is DOTTI used for?

DOTTI is an estrogen replacement that is used to prevent bone loss and relieve symptoms of menopause, such as hot flashes and vaginal dryness.

How does DOTTI work?

DOTTI replaces estrogen hormones that your body loses during menopause to relieve symptoms of menopause and prevent bone loss.

How do I take DOTTI?

The starting dose of DOTTI is started low and then increased as needed. It is a patch that is placed on the lower part of the stomach or upper part of the buttocks and replaced twice weekly.

Is it safe for me to take DOTTI?

DOTTI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take DOTTI if you are a woman who is over 35 years old and smoke. It should also not be used in women with any of the following medical conditions:

Undiagnosed abnormal vaginal bleeding
Known, suspected, or history of breast cancer
Known or suspected estrogen-dependent cancer
Active or history of deep vein thrombosis or pulmonary embolism
Stroke or myocardial infarction (heart attack) within the past year
Liver disease
Allergy to any of the ingredients in Activella
Known or suspected pregnancy

DOTTI Common Side Effects

Common side effects of DOTTI include:

Headache
Breast pain or tenderness
Flu-like symptoms
Stomach pain
Swelling
Back and body pain
Depression
Vaginal spotting
Upset stomach
Weight gain
Rashes
Vaginal discharge
Itching
Nausea

DOTTI Serious Side Effects

Serious side effects are rare with DOTTI. Contact your healthcare provider immediately if you experience any of the following.

Allergic reactions
Heart attack (hest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw)
Stroke (sudden trouble talking, trouble walking, numbness on one side of your body or face, sudden, severe headaches)
Shortness of breath
Breast lumps or pain
Unusual or heavy vaginal bleeding
Gallbladder problems (stomach pain, nausea or vomiting that doesn’t go away, fever, yellowing of the skin and eyes)

Effects of other drugs, drug classes and over-the-counter products on DOTTI

The following medications may interact with DOTTI:

Inducers of CYP3A4 such as St. John’s wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin may reduce the levels and effects of DOTTI
Inhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase the levels and effects of DOTTI

Who makes DOTTI?

Amneal Pharmaceuticals LLC

Is DOTTI safe in pregnancy?

DOTTI should not be used during pregnancy.

What is the generic name for DOTTI?

estradiol

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects

Drug Savings Tips

How can NowPatient help me to lower the cost of my DOTTI prescription?

How do the NowPatient DOTTI savings programs work?

Are the NowPatient DOTTI savings programs suitable for everyone, regardless of insurance status?

	Rx Advantage Card* for DOTTI	Canadian Prescription Savings* for DOTTI	DOTTI Drug Coupon*	DOTTI Patient Assistance Program*
Insured (federal, state or government)	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured (Commercial or Private)	Available	Available	Available If Offered by Pharmaceutical Company	Available If Offered by Pharmaceutical Company
Uninsured	Available	Available	Not Available	Available If Offered by Pharmaceutical Company
Insured but without pharmacy benefit or drug coverage	Available	Available	Not Available	Available If Offered by Pharmaceutical Company

Are the NowPatient drug savings programs suitable for brand and generic versions of DOTTI?

	Rx Advantage Card* for DOTTI	Canadian Prescription Savings* for DOTTI	DOTTI Drug Coupon*	DOTTI Patient Assistance Program*
Brand	Yes	Yes	Yes, If Offered by Pharmaceutical Company	Yes, If Offered by Pharmaceutical Company
Generic	Yes	Yes	No	No

If you have Medicare Part D or Medicare Advantage and none of the DOTTI savings options are applicable or affordable for me, what can you do?

I am uninsured or underinsured and none of the DOTTI prescription saving options are applicable or affordable for me, what can I do?

I am commercially or privately insured and none of the DOTTI prescription saving options are applicable or affordable for me, what can I do?

If I have federal, state or commercial insurance and none of the DOTTI prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?

If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:

1. Patient Access Network Foundation (PAN) assistance for DOTTI

If you are having trouble paying for your DOTTI medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for DOTTI you will need to meet one or all of the following criteria:

Your income is below 400% of the federal poverty level
DOTTI is prescribed for an approved FDA indication
You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
You have Medicare insurance coverage that covers DOTTI
If DOTTI is listed on PAN’s list of covered medications

You can check the Patient Access Network Foundation Website for more information.

2. HealthWell Foundation Copay Program for DOTTI

If you are having trouble paying for your DOTTI medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for DOTTI you will need to meet the following criteria:

You live in and are being treated in the United States
You are insured and your plan covers DOTTI
If DOTTI is listed on the HealthWell Foundation’s list of covered medications

You can check the HealthWell Foundation Website for more information.

3. Patient Advocate Foundation Co-Pay Relief Program for DOTTI

Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your DOTTI treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for DOTTI you will need to meet the following criteria:

You must be currently insured and have coverage for DOTTI
You must have a confirmed diagnosis and treatment plan
You must reside and receive treatment in the United States
Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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