Kliofem

Other Related Names or Treatments

Evorel, Femoston, Kliovance

About Kliofem

Kliofem tablets contains two active ingredients, estradiol, a natural version of oestrogen and norethisterone, a synthetic progestogen. It is classed as a HRT (hormone replacement therapy), used to treat women after menopause to replace oestrogen no longer made by the body. Menopausal symptoms include:

• Osteoporosis
• Hot flushes, night sweats
• Depression, mood swings
• Sleep problems
• Vaginal dryness

Kliofem is a continuous combined HRT treatment used in postmenopausal women who have not had a hysterectomy. If only oestrogen levels are increased during HRT treatment, the endometrium will grow excessively, causing an increased risk of endometrial cancer. Women who have not had a hysterectomy are therefore given HRT that contains progestogen.

NowPatient offers Kliofem tablets as a treatment for HRT only, following an online consultation with a prescribing clinician.

Key facts of Kliofem

• For the treatment of HRT
• Kliofem has some common side effects which include nausea and headaches
• Kliofem will not prevent pregnancy in otherwise fertile women
• Do not use a hormonal contraceptive when treated with a HRT
• It can be dangerous if you take Kliofem with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
• Kliofem has a lower dose of oestrogen and progesterone and is more suitable for women who are more sensitive to hormones

Who is Kliofem not suitable for?

Kliofem may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Kliofem if you:

• Have hypersensitivity to the active ingredients estradiol hemihydrate or norethisterone acetate
• Have ever had breast cancer
• Have cancer sensitive to oestrogen
• Have untreated endometrial hyperplasia (an excessively thick womb lining)
• Suffer from a blood clots
• Suffer from porphyria
• Have had a heart attack, angina, stroke, or high blood pressure
• Have unusual vaginal bleeding
• Have liver disease or any other liver problems
• Are pregnant or breastfeeding
• Have fibroids
• Have uterine problems such as endometriosis or endometrial hyperplasia
• Have diabetes
• Suffer from migraines
• Have gallbladder disease
• Have asthma
• Have epilepsy
• Have fluid retention
• Have high cholesterol levels in the blood
• Are obese
• Have a hereditary ear disorder

How and where to get Kliofem?

You can buy Kliofem safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.

Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of HRT, you can discuss if Kliofem is a suitable treatment option for you.

At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.

Dosage and strength for Kliofem tablets for HRT

Kliofem tablets contain 2mg estradiol and 1mg norethisterone acetate.

Information about how to take Kliofem for HRT

Kliofem tablets should be taken at the same time each day. Swallow the tablets whole with water, with or without food. Start a new pack once you finish your current pack, without a break.

If you forget to take a tablet, take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Read the patient information leaflet provided or speak to a healthcare professional for further information.

What happens if you take too much Kliofem?

If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Kliofem and you experience any of the following side effects:

What are the side effects of Kliofem?

Possible side effects of Kliofem are split into common and serious.

Common side effects include:

• Nausea
• Headache, dizziness
• Breast tenderness, breast pain
• Change in sex drive
• Anxiety, insomnia
• Stomach cramps, indigestion, flatulence, diarrhoea
• Breakthrough bleeding
• Acne, skin irritation, rash
• Vaginal discharge
• Fluid retention, weight gain, bloating
• Infection

Serious side effects include:

• Blood clots
• Stroke
• Heart disease – chest pain passing into the neck or arm
• Liver disease – jaundice (yellowing of the skin or eyes), abdominal pain

If you experience any serious side effects, you should contact NHS 111.

If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.

• Your lips, mouth, throat or tongue suddenly become swollen
• You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
• Your throat feels tight or you’re struggling to swallow
• Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• You suddenly become very confused, drowsy or dizzy
• Someone faints and cannot be woken up

Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient

Information about taking Kliofem at the same time as other medications or herbal supplements

There is not enough evidence to suggest there are any drug interactions between herbal supplements and Kliofem. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other prescription drugs, such as:

• Phenytoin or carbamazepine
• Rifampicin
• Ritonavir or nelfinavir
• Warfarin
• St John’s Wort

Can Kliofem taken for HRT be taken long term?

HRT should only be used as a short-term treatment for the menopause. Speak to your GP to review your treatment at least once each year and have regular checkups.

Is there a herbal Kliofem?

No. Herbal Kliofem does not exist. If you have been marketed such a formulation, it may be fake.

Can women use Kliofem?

Women can take Kliofem for HRT, but should speak to a doctor if considering taking it while pregnant or breastfeeding.

Should I avoid any particular food or drink when taking Kliofem?

You can eat and drink normally when taking Kliofem.

What lifestyle changes can I make to help me with HRT?

You modify your lifestyle in a number of ways, and this may have a positive impact on your symptoms:

• Using a fan
• Cool showers
• Light clothing
• Lubricants
• Healthy diet
• Regular exercise
• Quit smoking

Alternatives to Kliofem

Alternative HRT treatments include Femoston, Evorel, and Premarin.

Sources

•  HRT – NHS 
•  MHRA Products – Home