conjugated estrogens
Used for Menopause
NowPatient helps you obtain your conjugated estrogens prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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conjugated estrogens key facts
What dosages is conjugated estrogens available in?
conjugated estrogens are available as a 0.3, 0.45, 0.625, 0.9, and 1.25 mg oral tablet.
What is conjugated estrogens used for?
conjugated estrogens is an estrogen replacement and is used for the following:
- Hot flashes, night sweats, and flushes caused by menopause
- Vaginal dryness and pain caused by menopause
- Low estrogen levels due to certain conditions
- Pain caused by breast cancer that has spead to other parts of the body
- Pain caused by advanced prostate cancer
- Prevention of bone loss (osteoporosis) after menopause
How does conjugated estrogens work?
conjugated estrogens contains a type of estrogen, a natural hormone in your body. This medication replaces the estrogen that your body loses during menopause. Replacing estrogen strengthens bones and relieves symptoms of menopause, like vaginal dryness and irritation, hot flashes, and night sweats. The tablets can also help with the pain that happens with some forms of advanced breast and prostate cancer.
How do I take conjugated estrogens?
conjugated estrogens is dosed as follows:
- Menopausal symptoms: The typical starting dose is 0.3 mg by mouth once a day
- Low estrogen: The starting dose is determined by your provider based on the condition causing low estrogen. The starting dose ranges from 0.3 mg to 1.25 mg by mouth once a day for 3 weeks, with 1 week off (no tablets taken during this week). Then this cycle is repeated
- Breast cancer: The typical dose is 10 mg by mouth 3 times a day for at least 3 months
- Prostate cancer: The typical dose is 1.25 mg to 2.5 mg by mouth 3 times a day
- Prevention of bone loss (osteoporosis): The typical starting dose is 0.3 mg by mouth once a day
Is it safe for me to take conjugated estrogens?
conjugated estrogens is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if the following apply:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic diseases
- Known or suspected estrogen-dependent neoplasia.
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions.
- Known anaphylactic reaction or angioedema with PREMARIN
- Known liver impairment or disease
- Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
- Known or suspected pregnancy
conjugated estrogens Common Side Effects
Common side effects of conjugated estrogens:
- Headache
- Abnormal vaginal bleeding
- Breast pain
- Stomach pain
- Passing gas
conjugated estrogens Serious Side Effects
Serious side effects are rare with conjugated estrogens. Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: rash, itching, swollen lips or tongue, trouble breathing, stomach pain, vomiting
- Heart attack: chest pain or tightness, shortness or breath, sweating, nausea, pain that radiates up to your shoulder, arm, neck, or jaw
- Stroke: sudden trouble talking or walking, numbness on one side of your body or face, severe headache, dizziness, confusion
- Blood clot: chest pain, shortness of breath, dizziness, fast heart rate, swelling, pain, or redness in the arms or legs
- Cancer: lumps, pain, swelling, or changes in the breasts; swollen lymph nodes, unusual or heavy vaginal bleeding, bloating, extreme tiredness, stomach-area pain
Effects of other drugs, drug classes and over-the-counter products on conjugated estrogens
The following medications may interact with conjugated estrogens:
- Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism
Who makes conjugated estrogens?
Various FDA-approved generic manufacturers
Is conjugated estrogens safe in pregnancy?
conjugated estrogens should not be used during pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my conjugated estrogens prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your conjugated estrogens prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient conjugated estrogens savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient conjugated estrogens savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for conjugated estrogens | Canadian Prescription Savings* for conjugated estrogens | conjugated estrogens Drug Coupon* | conjugated estrogens Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of conjugated estrogens?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for conjugated estrogens | Canadian Prescription Savings* for conjugated estrogens | conjugated estrogens Drug Coupon* | conjugated estrogens Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the conjugated estrogens savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the conjugated estrogens drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for conjugated estrogens, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the conjugated estrogens prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, conjugated estrogens is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed conjugated estrogens for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the conjugated estrogens prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the conjugated estrogens prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for conjugated estrogens
If you are having trouble paying for your conjugated estrogens medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for conjugated estrogens you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- conjugated estrogens is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers conjugated estrogens
- If conjugated estrogens is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for conjugated estrogens
If you are having trouble paying for your conjugated estrogens medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for conjugated estrogens you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers conjugated estrogens
- If conjugated estrogens is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for conjugated estrogens
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your conjugated estrogens treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for conjugated estrogens you will need to meet the following criteria:
- You must be currently insured and have coverage for conjugated estrogens
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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