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Premarin Vaginal Cream is the brand name for conjugated estrogens and is available as a vaginal cream.

Premarin Vaginal Cream is available as a vaginal cream that contains 0.625 mg/g.

Premarin Vaginal Cream is an estrogen replacement and is used for the following:

• Vaginal thinning, dryness, and pain
• Severe itching and inflammation in the vagina
• Pain during vaginal sex caused by menopause

Premarin Vaginal Cream contains a type of estrogen, a natural hormone in your body. This medication replaces the estrogen that your body loses during menopause. Replacing estrogen strengthens bones and relieves symptoms of menopause, like vaginal dryness and irritation, hot flashes, and night sweats. The vaginal cream only works in the vagina where you apply it, so it only relieves vaginal dryness and irritation.

Premarin Vaginal Cream is dosed as follows:
Vaginal thinning caused by conditions other than menopause: Using the included applicator, apply 0.5 grams to into the vagina once a day for 3 weeks, then apply no cream for 1 week. Then this cycle is repeated. Vaginal dryness and irritation casued by menopause: Using the included applicator, apply 0.5 grams into the vagina twice a week.

Premarin Vaginal Cream is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if the following apply:

• Undiagnosed abnormal genital bleeding
• Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic diseases.
• Known or suspected estrogen-dependent neoplasia
• Active DVT, PE, or a history of these conditions. Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions.
• Known anaphylactic reaction or angioedema with PREMARIN
• Known liver impairment or disease
• Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
• Known or suspected pregnancy

Common side effects of Premarin Vaginal Cream:

• Breast pain
• Headache
• Pelvic pain
• Vaginal discharge

Serious side effects are rare with Premarin Vaginal Cream. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: rash, itching, swollen lips or tongue, trouble breathing, stomach pain, vomiting
• Heart attack: chest pain or tightness, shortness or breath, sweating, nausea, pain that radiates up to your shoulder, arm, neck, or jaw
• Stroke: sudden trouble talking or walking, numbness on one side of your body or face, severe headache, dizziness, confusion
• Blood clot: chest pain, shortness of breath, dizziness, fast heart rate, swelling, pain, or redness in the arms or legs
• Cancer: lumps, pain, swelling, or changes in the breasts; swollen lymph nodes, unusual or heavy vaginal bleeding, bloating, extreme tiredness, stomach-area pain

The following medications may interact with Premarin Vaginal Cream:

• Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism

Pfizer

Premarin Vaginal Cream should not be used during pregnancy.

• Conjugated Estrogens