Buy Duloxetine Online. No Consultation Fee, Free Next-Day Delivery
Get prescribed Duloxetine for Urinary Incontinence by a UK clinician through a free video consultation*. No questionnaires, no hidden fees. You only pay for your medication if approved.
Other Related Treatments
MEDICAL INFORMATION
Duloxetine Key Facts
Other Related Names or Treatments
Cymbalta
About Duloxetine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by increasing serotonin and noradrenaline, in your brain. Duloxetine is used to treat major depressive disorder (MDD), generalized anxiety disorder, nerve pain, such as fibromyalgia, diabetic peripheral neuropathy, and also stress urinary incontinence in women.
It is available with a prescription as generic Duloxetine or under brand names such as Cymbalta or Yentreve. NowPatient offers Duloxetine or Yentreve as treatments for urinary incontinence only, following an online consultation with a prescribing clinician.
Key facts about Duloxetine
- For the treatment of stress urinary incontinence in women
- It can be dangerous if you take Duloxetine with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- Duloxetine may take 2 to 4 weeks to start working, but may take longer if you’re using it for nerve pain
- Common side effects of Duloxetine include nausea, dry mouth, constipation and drowsiness
- If you decide to stop taking Duloxetine, your doctor may reduce your dose in steps, to prevent withdrawal symptoms
Who is Duloxetine suitable for?
Duloxetine is suitable for:
- Most adults 18 years of age and over
Who is Duloxetine not suitable for?
Duloxetine may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Duloxetine if you:
- Have had an allergic reaction to Duloxetine
- Have kidney or liver problems
- Have heart problems
- Have taken other medication for depression within the last 14 days
- Have glaucoma
- Suffer from seizures, fits, manic episodes or bipolar disorder
- Are pregnant, trying to get pregnant, or you’re breastfeeding
How and where to get Duloxetine?
You can buy Duloxetine safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of urinary incontinence, you can discuss if Duloxetine is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Duloxetine for urinary incontinence
Duloxetine is available as delayed-release capsules when used for urinary incontinence. For stress urinary incontinence, Duloxetine is available in strengths ranging from 20mg and 40mg capsules.
Information about how to take Duloxetine for urinary incontinence
For stress urinary incontinence, the starting dose of Duloxetine is 20mg twice a day, increased to 40mg twice a day, after 2 weeks. Take Duloxetine with or without food, at the same time each day. Swallow Duloxetine capsules whole with a glass of water. Duloxetine may be taken long-term for urinary incontinence, if it is helping your symptoms. Speak to a healthcare professional or read the patient information leaflet provided for further medical advice.
What happens if you take too much Duloxetine?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Duloxetine and you experience any of the following side effects:
What are the side effects of Duloxetine?
Side effects of Duloxetine are split into common and serious.
Common side effects include:
- Problems sleeping
- Headaches, dizziness, blurred vision, drowsiness
- Constipation, diarrhoea
- Nausea or vomiting
- Dry mouth
- Tiredness
- Loss of appetite, weight loss
Serious side effects include:
- Serotonin syndrome – agitation, hallucinations, shivering, muscle stiffness, fast heart rate
- Constant headaches
- Liver problems -yellowing of the whites of your eyes or skin
- Blurred vision or eye pain
- Coughing up blood or blood in your stools or urine
- Bruising easily
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Information about taking Duloxetine at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Duloxetine. In any event, you should let your prescribing clinician know if you are taking any other medicines, such as:
- Selective serotonin reuptake inhibitors (SSRIs) such as citalopram, fluoxetine, or sertraline
- Serotonin-norepinephrine reuptake inhibitors such as venlafaxine
- Tricyclic antidepressants such as amitriptyline
- Monoamine oxidase inhibitors (MAOIs) such as linezolid, methylene blue, or phenelzine
- Opioids such as fentanyl and tramadol
- St. John’s wort
- Warfarin
- Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen
- Antibiotics such as ciprofloxacin
Can Duloxetine taken for urinary incontinence be taken long-term?
Yes. Duloxetine may be taken long-term for urinary incontinence, if it is helping your symptoms. Speak to a healthcare professional or read the patient information leaflet provided for further medical advice.
Is there a herbal Duloxetine?
No. Herbal Duloxetine does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Duloxetine?
Women can only take Duloxetine for the treatment of stress urinary incontinence. Duloxetine is not recommended during pregnancy. Speak to your doctor if you get pregnant. You may continue to take Duloxetine while breastfeeding if your doctor says your baby is healthy. Duloxetine does pass into breast milk, but does not cause side effects in breastfed babies. Speak to your doctor if you’re breastfeeding, or planning to breastfeed.
Should I avoid any particular food or drink when taking Duloxetine?
You can eat and drink normally when taking Duloxetine.
What lifestyle changes can I make to help me with urinary incontinence?
Modifying your lifestyle may have a positive impact on your urinary incontinence. These may include:
- Practice Kegel exercises to improve your bladder control
- Stay well hydrated to maintain a healthy urinary function
- Avoid caffeine, alcohol, and spicy foods
- Urinate when you feel the urge to
- When urinating, wait once you have finished for a few moments, and then try again to make sure the bladder is emptied completely
Alternatives to Duloxetine
Alternatives for the treatment of urinary incontinence include tamsulosin and tolteridone.
Sources
- Taking Duloxetine with other medicines and herbal supplements – NHS
- Duloxetine: Side effects, dosage, uses, and more
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Duloxetine
What is Duloxetine?
Duloxetine is a serotonin and noradrenaline reuptake inhibitor (SNRI) available as gastro-resistant capsules in strengths of 20 mg, 30 mg, 40 mg, and 60 mg. It is licensed in the UK for the treatment of major depressive disorder, generalised anxiety disorder, diabetic peripheral neuropathic pain, and stress urinary incontinence (as branded Yentreve 40 mg). Duloxetine is a prescription-only medicine. Brand names include Cymbalta and Yentreve.
How does Duloxetine work?
Duloxetine inhibits the reuptake of both serotonin and noradrenaline in the brain and spinal cord, increasing the availability of these neurotransmitters. For depression and anxiety, this enhances mood regulation and reduces excessive worry. For neuropathic pain, the increased noradrenaline and serotonin activity in descending pain inhibitory pathways reduces pain signal transmission. For stress urinary incontinence, duloxetine increases the tone of the urethral sphincter through its action on Onuf’s nucleus in the sacral spinal cord.
What is Duloxetine used for?
Duloxetine is licensed for major depressive disorder (60 mg daily), generalised anxiety disorder (30–60 mg daily), diabetic peripheral neuropathic pain (60 mg daily), and stress urinary incontinence (as Yentreve 40 mg twice daily). Off-label uses include chronic pain conditions such as fibromyalgia and chronic musculoskeletal pain. The dose depends on the indication and should be determined by your prescriber.
How do I take Duloxetine?
Swallow duloxetine capsules whole with water — do not crush, chew, or open them, as the gastro-resistant coating prevents degradation in stomach acid. Take at the same time each day, with or without food. For depression: the usual dose is 60 mg once daily. For anxiety: start at 30 mg daily, increasing to 60 mg after 2 weeks if needed. For neuropathic pain: 60 mg once daily (start at 30 mg for 2 weeks if preferred). For stress urinary incontinence: 40 mg twice daily (as Yentreve).
How long does Duloxetine take to work?
For depression and anxiety, duloxetine may begin to improve symptoms within 1–2 weeks, but full therapeutic effect usually takes 4–6 weeks. For neuropathic pain, some improvement may be noticed within the first week, with maximum benefit at 4–8 weeks. For stress urinary incontinence, benefits are typically seen within 2–4 weeks. Continue taking duloxetine as prescribed even if you do not feel immediate improvement.
What are the common side effects of Duloxetine?
Very common side effects include nausea (most common, especially in the first 1–2 weeks), headache, dry mouth, and somnolence (drowsiness). Common side effects include dizziness, constipation, diarrhoea, fatigue, decreased appetite, insomnia, increased sweating, and sexual dysfunction (reduced libido, difficulty reaching orgasm, erectile dysfunction). Nausea usually improves within the first 1–2 weeks. Taking duloxetine with food may help reduce nausea.
Can I stop Duloxetine suddenly?
No, duloxetine should not be stopped abruptly. Sudden discontinuation can cause withdrawal symptoms including dizziness, nausea, headache, paraesthesia (tingling or electric shock sensations, sometimes called ‘brain zaps’), irritability, insomnia, anxiety, and diarrhoea. The dose should be gradually tapered over at least 2 weeks under your prescriber’s guidance. A common tapering schedule is reducing to the next lower dose for 2 weeks before stopping completely.
Who should not take Duloxetine?
Duloxetine should not be taken by people currently taking or recently stopped taking MAO inhibitors (allow 14 days washout), those with uncontrolled narrow-angle glaucoma, severe hepatic impairment, severe renal impairment (creatinine clearance <30 mL/min), or those taking fluvoxamine (strong CYP1A2 inhibitor). Caution is needed in patients with hypertension (duloxetine can increase blood pressure), bleeding disorders, epilepsy, and bipolar disorder. It should be used with caution in pregnancy.
Can I drink alcohol with Duloxetine?
Alcohol should ideally be avoided while taking duloxetine. Both substances affect the central nervous system, and combining them may increase drowsiness, dizziness, and impaired judgement. Alcohol can also worsen depression and anxiety. Additionally, both duloxetine and alcohol are metabolised by the liver, and the combination may increase the risk of liver toxicity. If you choose to drink, keep consumption minimal.
How can I get Duloxetine?
Duloxetine requires a prescription from your GP, psychiatrist, pain specialist, or online prescriber such as NowPatient. It is available on the NHS. Your prescriber will assess the appropriate indication and dosage. NowPatient offers online consultations with qualified UK prescribers for convenient access.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
Report to
OUR CUSTOMERS VIEW
What Customers Love About Our Service
We want everyone to be happy and healthy, that’s what keeps us going. Read what some of them have to say about us.
Medicines Experts
Meet Our Medical Team
We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
