Treatment options

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Updated on 4 Apr 2024

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Other known brand names

Blerone, Detrusitol, Neditol XL, Preblacon, Detrol LA

About Mariosea XL

Mariosea XL contains tolterodine tartrate, an antimuscarinic, as its active ingredient. It helps to reduce bladder muscle spasms and the urge to frequently urinate, caused by these spasms. Mariosea XL is used to treat the symptoms of an overactive bladder, such as:

  • Urinary urgency (a sudden and urgent need to pee)
  • Urinary frequency (needing to pee more often than usual)
  • Urinary incontinence (wetting yourself)

Tolterodine relaxes muscles around your bladder, allowing your bladder to hold more liquid, stopping you from needing to pee as often or as urgently. It is available with a prescription as generic tolterodine or under brand names such as Detrusitol, Mariosea XL and Neditol.

NowPatient offers generic tolterodine or the branded treatments for urinary incontinence only, following an online consultation with a prescribing clinician.

Key facts of Mariosea XL

  • For the treatment of urinary incontinence
  • Mariosea XL starts to work within 3 to 8 hours but full effects may take up to 4 weeks to be seen
  • Possible side effects of Mariosea XL include dry mouth or headache
  • It can be dangerous if you take Mariosea XL with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
  • You will normally take Mariosea XL slow-release capsules once daily

Who is Mariosea XL suitable for?

Tolterodine may be taken by adults. It may also be given to children 2 years of age and over, on specialist advice.

Who is Mariosea XL not suitable for?

Mariosea XL may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Mariosea XL if you:

  • Have had an allergic reaction to the active ingredient tolterodine
  • Have urinary retention
  • Have gastric retention
  • Have kidney or liver disease
  • Have myasthenia gravis
  • Have uncontrolled narrow-angle glaucoma
  • Have a severe stomach or bowel condition
  • Have toxic megacolon or ulcerative colitis
  • Have any heart problems such as heart failure, long QT syndrome, or an irregular or slow heart rate (bradycardia)
  • Have heartburn or acid reflux
  • Have a hiatus hernia
  • Have any nerve damage
  • Are pregnant, trying to get pregnant or breastfeeding

How and where to get Mariosea XL?

Mariosea XL is available, only with a prescription. It is not available over the counter at a pharmacy.

NowPatient does not allow customers to buy Mariosea XL directly. Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of urinary incontinence, you can discuss if Mariosea XL is a suitable treatment option for you.

At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.

Dosage and strength for Mariosea XL for urinary incontinence

Mariosea XL is available as 2 mg and 4 mg prolonged-release capsules when used for urinary incontinence.

Information about how to take Mariosea XL for urinary incontinence

Mariosea XL extended-release capsules should be taken whole with a glass of water, with or without food, at the same time each day. Do not chew, crush or break open the capsules.

You will normally take 4mg once a day, unless you have liver or kidney problems, in which case you will be prescribed 2mg tablets once a day. For further information please speak to a healthcare professional for medical advice.

What happens if you take too much Mariosea XL?

If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Mariosea XL and you experience any of the following side effects:

What are the side effects of Mariosea XL?

Side effects of Mariosea XL are split into common and serious.

Common side effects include:

  • Dry mouth
  • Dry eyes
  • Dry skin
  • Headache
  • Dizziness, drowsiness, blurred vision
  • Gastrointestinal side effects such as diarrhoea, constipation, vomiting, burping, or passing wind, stomach pain
  • Palpitations

Serious side effects include:

  • Faecal impaction
  • Urinary retention
  • Urinary tract infection (UTI)
  • Swollen ankles or legs
  • Angioedema – swollen face, throat or tongue, difficulty swallowing or breathing
  • Disorientation

If you experience any serious side effects, you should contact NHS 111.

If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.

  • Your lips, mouth, throat or tongue suddenly become swollen
  • You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • Chest pain
  • Your throat feels tight or you’re struggling to swallow
  • Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • You suddenly become very confused, drowsy or dizzy
  • Someone faints and cannot be woken up

Information about taking Mariosea XL at the same time as other medications or herbal supplements

There may be drug interactions when using herbal remedies and supplements when taking Mariosea XL. In any event, you should let your prescribing clinician know if you are taking any herbal supplements or other medicinal products, such as:

  • Erythromycin or clarithromycin
  • Ketoconazole or itraconazole
  • Metoclopramide or cisapride
  • Medication for irregular heartbeats such as amiodarone, sotalol, quinidine or procainamide
  • Cyclosporine
  • Vinblastine

Can Mariosea XL taken for urinary incontinence be taken long term?

You should not take Mariosea XL longer than you need to. Your doctor will check that you still need to take Mariosea XL every 6 to 12 months.

Is there a herbal Mariosea XL?

No. Herbal Mariosea XL does not exist. If you have been marketed such a formulation, it may be fake.

Can women use Mariosea XL?

Women can take Mariosea XL, but it is not recommended in pregnancy or when breastfeeding. Speak to your doctor about taking Mariosea XL if you’re pregnant, trying to get pregnant, or when breastfeeding.

Should I avoid any particular food or drink when taking Mariosea XL?

You can eat and drink normally when taking Mariosea XL. Some drinks may however irritate your bladder, making your symptoms worse. These include:

  • Coffee, tea, cola and energy drinks
  • Fizzy drinks
  • Alcohol
  • Diet drinks or those with artificial sweeteners
  • Citrus, orange, grapefruit or lime juice

What lifestyle changes can I make to help me with urinary incontinence?

Modifying your lifestyle may have a positive impact on your urinary incontinence and quality of life. These may include:

  • Pelvic floor muscle training to improve your bladder control
  • Stay well hydrated to maintain a healthy urinary function
  • Avoid caffeine, alcohol, and spicy foods
  • Urinate when you feel the urge to
  • When urinating, wait once you have finished for a few moments, and then try again to make sure the bladder is emptied completely

Alternatives to Mariosea XL

Alternatives for the treatment of urinary incontinence include Betmiga, Detrusitol, Yentreve and Emselex.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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