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MEDICAL INFORMATION
Obgemsa Key Facts
Other Related Names or Treatments
Gemtesa
About Obgemsa
Obgemsa is indicated for the symptomatic treatment of overactive bladder (OAB) syndrome in adults. Obgemsa contains vibegron as its active ingredient, which works by activating certain receptors in the bladder detrusor muscle. By relaxing detrusor smooth muscle, Obgemsa helps to increase bladder capacity during bladder filling.
Obgemsa is available in a tablet formulation and is used in individuals aged 18 years of age and older. Obgemsa is a prescription-only medication and may be recommended when other treatments have not been effective or are not well tolerated.
NowPatient offers Obgemsa as a treatment for urinary incontinence following an online consultation with a prescriber.
Key facts of Obgemsa
- For the treatment of urinary incontinence
- Obgemsa has some common side effects which include constipation, diarrhoea, headache and nausea
- Obgemsa can interact with ketoconazole, diltiazem and rifampicin. If you’re not sure if it is safe to use with other treatments, discuss this with the prescribing clinician
- Obgemsa may be used when other treatments have not been effective or are not suitable
- Signs of urinary retention should be monitored before and during treatment, especially in patients with clinically significant bladder outlet obstruction, conditions predisposing for bladder outlet obstruction, and in patients taking muscarinic antagonists
Who is Obgemsa suitable for?
Obgemsa is suitable for use in adults over the age of 18.
Who is Obgemsa not suitable for?
Obgemsa may not be suitable for some people. To make sure it’s safe for you, speak to the NowPatient prescribing clinician before using Obgemsa if you:
- Are pregnant or planning to become pregnant
- Are breastfeeding
- Have a history of allergic reactions to Obgemsa or any ingredients in the tablet formulation
- Are under 18 years of age
How and where to get Obgemsa?
You can buy Obgemsa safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of urinary incontinence, you can discuss if Obgemsa is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength of Obgemsa for urinary incontinence
Obgemsa is available as a film coated tablet, containing 75 mg of vibegron as its active ingredient. Obgemsa is taken orally with or without food. Obgemsa may be taken with a glass of water or it may be crushed and mixed with a tablespoon of soft food such as applesauce and taken immediately with a glass of water.
What happens if you use too much Obgemsa?
Using more than the prescribed amount of Obgemsa will not improve your urinary incontinence faster and can increase the risk of side effects such as constipation, diarrhoea or headaches.
If you have taken too much and experience side effects, speak to your doctor or reach out to one of our prescribing clinicians.
What are the side effects of Obgemsa?
Side effects of Obgemsa are split into common and uncommon.
Common side effects include:
- Constipation
- Diarrhoea
- Headache
- Nausea
- Urinary tract infection
Uncommon side effects include:
- Hot flush
- Skin reactions
- Urinary disorders
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below, you should contact emergency services on 999:
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA Yellow Card reporting system. You can read more about this here: How and where do I report side effects of my medication?
Information about using Obgemsa with other medications
Using Obgemsa alongside other treatments, especially products containing dabigatran etexilate, apixaban or rivaroxaban can increase the risk of interactions. Let your prescribing clinician know if you are using any other medications before starting treatment with Obgemsa.
Why might Obgemsa not work for urinary incontinence?
Obgemsa may not work for urinary incontinence due to variations in individual response to the medication, when it was given and potential drug interactions. Additionally, over time, some people may experience a change in effectiveness, which may require a change in treatment or dosage.
Can Obgemsa be used long term?
Obgemsa can be used as long as your clinician recommends it. You should always be monitored by a healthcare professional when taking medication.
How to store Obgemsa
- Keep Obgemsa out of the sight and reach of children
- Do not use this medicine after the expiry date shown on the carton (marked as “EXP”). The expiry date refers to the last day of that month
- No special storage conditions are required for this medicine
- Do not dispose of unused Obgemsa tablets in wastewater or household waste. Ask your pharmacist how to properly dispose of medicines you no longer use. These steps help protect the environment
Is there a herbal Obgemsa?
No. Herbal Obgemsa does not exist. If you have been marketed such a product, it may be counterfeit or unsafe.
Should I avoid any particular food or drink when using Obgemsa?
You can eat and drink normally while using Obgemsa. However, it’s important to take Obgemsa with a glass of water.
What lifestyle changes can I make to help with urinary incontinence?
There are several lifestyle changes that may improve your urinary incontinence:
- Maintain a healthy weight
- Pelvic floor exercises
- Managing fluid intake
- Avoiding caffeine and alcohol
- Quit smoking
Alternatives to Obgemsa
Alternatives for the treatment of urinary incontinence include:
- Duloxetine (Yentreve)
- Darifenacin (Emselex)
- Mirabegron (Betmiga)
- Tolterodine (Detrusitol)
- Oxybutinin (Ditropan)
Your prescriber will help decide which option is most suitable for you.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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FAQs
Answers to Popular Questions About Obgemsa
What is Obgemsa?
Obgemsa is a prescription medication containing vibegron 75 mg, a selective beta-3 adrenergic receptor agonist used for the symptomatic treatment of overactive bladder (OAB) syndrome in adults. It helps to reduce symptoms of urgency, increased urinary frequency, and urge urinary incontinence. Obgemsa is manufactured by Pierre Fabre and was approved by the MHRA in July 2024. It is a prescription-only medicine and is subject to additional monitoring.
How does Obgemsa work?
Obgemsa works by selectively activating beta-3 adrenergic receptors located in the detrusor muscle of the bladder wall. This activation promotes relaxation of the detrusor smooth muscle during bladder filling, increasing bladder capacity and reducing involuntary contractions that cause urgency and incontinence. Unlike antimuscarinic drugs (such as oxybutynin or solifenacin), vibegron does not block muscarinic receptors, so it has a lower incidence of anticholinergic side effects such as dry mouth, constipation, and cognitive impairment.
How effective is Obgemsa?
In the EMPOWUR phase 3 clinical trial of 1,515 patients with OAB, vibegron 75 mg significantly reduced daily micturition frequency and urge incontinence episodes compared to placebo. The benefits were observed within 2 weeks and maintained over 52 weeks of treatment. Vibegron was shown to be as effective as tolterodine (an established antimuscarinic) while offering a different side effect profile. Daily urination decreased by approximately 1.8 episodes per day compared to 1.3 with placebo.
How do I take Obgemsa?
Take one Obgemsa 75 mg tablet once daily with a glass of water, with or without food. The tablet can also be crushed and mixed with a tablespoon of soft food (such as applesauce) and taken immediately with water if you have difficulty swallowing. Take at the same time each day. Improvement in OAB symptoms is typically noticed within 2 weeks.
What are the side effects of Obgemsa?
Common side effects include urinary tract infection (6.6%), headache (5.0%), diarrhoea (3.1%), and nausea (3.0%). These are generally mild. An uncommon side effect is urinary retention — tell your doctor straight away if you are unable to empty your bladder. Unlike antimuscarinic OAB treatments, vibegron does not cause significant dry mouth, constipation, or cognitive impairment. Vibegron does not cross the blood-brain barrier, reducing the risk of central nervous system side effects.
Who is Obgemsa suitable for?
Obgemsa is suitable for adults with overactive bladder symptoms including urgency, increased urinary frequency, and urge incontinence. It may be particularly appropriate for patients who have not responded adequately to or cannot tolerate antimuscarinic medications, or where anticholinergic side effects (dry mouth, constipation, cognitive effects) are a concern. It should not be used in patients with hypersensitivity to vibegron, and caution is advised in patients with bladder outlet obstruction. Obgemsa has not been studied in patients with severe hepatic impairment.
How can I get Obgemsa?
Obgemsa requires a prescription from your GP, urologist, or online prescriber such as NowPatient. It is available on NHS prescription and through private prescribers. NowPatient offers online consultations for overactive bladder treatment and can check current stock availability.
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