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How long should I take pregabalin for nerve pain?

How long should I take pregabalin for nerve pain?

Navin Khosla NowPatientGreen tick
Updated on 28 May 2024

Pregabalin has emerged as a treatment option for many patients grappling with chronic pain conditions, particularly nerve pain relief. Understanding the correct usage of pregabalin, including the optimal duration for its use is crucial for maximizing its benefits while minimizing potential risks. Through this article, readers will gain valuable insights into improving their pregabalin therapy for effective nerve pain relief.

Understanding pregabalin

What is pregabalin?

Pregabalin is a medication mainly used to manage various forms of neuropathic pain, which is pain coming from damaged nerves. Pain can occur in multiple parts of the body, such as the arms, hands, fingers, legs, feet, or toes. Pain is typically due to conditions like diabetes, following an outbreak of shingles (postherpetic neuralgia) or spinal cord injury. Additionally, pregabalin is effective in treating fibromyalgia, a chronic condition characterized by pain, muscle stiffness, and fatigue, as well as epilepsy and partial-onset seizures, in both adults and children.

Pregabalin’s role in treating nerve pain

Pregabalin has been proven effective in the treatment of various types of neuropathic pain, including peripheral diabetic neuropathy, fibromyalgia, post-herpetic neuralgia, and pain associated with cancer chemotherapy. The drug achieves its effects by inhibiting overactive nerves that contribute to pain, thereby providing relief. It is the first medication to receive FDA approval specifically for the treatment of diabetic neuropathy and post-herpetic neuralgia, marking a significant milestone in neuropathic pain management.

Short-term vs. Long-term use

Pregabalin is recommended as a first-line treatment for various neuropathic pain conditions, such as diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN), and central pain. Clinical guidelines suggest that the medication should be carefully increased to achieve the best possible pain relief with tolerable side effects. Typically, treatment duration in clinical studies range from 2 to 16 weeks, but the exact duration can vary based on the individual’s response and the specific condition being treated.

For conditions like diabetic neuropathy and postherpetic neuralgia, initial doses are generally lower, gradually increasing, based on patient tolerance and effectiveness. The goal is to find a dose that provides the best possible pain relief without adverse effects. If, after an initial period (usually 2 to 4 weeks of treatment), there is insufficient pain relief at lower doses, a higher dose may be considered.

Factors influencing treatment duration

Individual response to medication

The duration of pregabalin treatment can vary significantly depending on how individuals respond to the medication. It has been observed that higher doses of pregabalin, such as 600 mg/day divided into two or three doses, can lead to a faster reduction in pain scores compared to lower doses. This rapid pain reduction is particularly notable in patients who receive the maximum recommended dosage. However, it is essential to monitor for any adverse effects that may arise with increased dosages.

Severity and type of nerve pain

The type and severity of nerve pain a patient experiences plays a crucial role in determining the appropriate duration of pregabalin treatment. For instance, pregabalin at fixed dosages of 300 and 600 mg/day has shown superior efficacy over placebo in relieving pain and improving pain-related sleep interference in patients with painful diabetic peripheral neuropathy over 5-8 weeks. Furthermore, an 8-week administration of pregabalin ranging from 75-300 mg/day has been effective in providing significant and long-lasting pain relief in chemotherapy-induced neuropathic pain among pediatric oncological patients.

Other medical conditions

Other medical conditions can also affect the duration of pregabalin treatment. Older patients, aged 65 years and above with diabetic peripheral neuropathy or post-herpetic neuralgia have shown a reduction in neuropathic pain with pregabalin treatment compared to younger patients. Additionally, patients with a history of adverse reactions to small doses of other medications may also experience similar reactions to pregabalin, which can affect the duration of treatment and dosage adjustments. Dosing of pregabalin should be based on an individuals tolerability and medical history to optimize effectiveness while minimizing adverse effects.

Possible side effects of pregabalin use

Common side effects

Many individuals taking pregabalin may experience side effects. These include:

  • Accidental injury: Increased risk due to changes in balance or coordination
  • Blurred vision: This can affect daily activities and may adjust over time
  • Changes in sensory perception: Including burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • Cognitive and motor function: Difficulty with speaking, memory problems, an unsteady walk, and lack of coordination are noted
  • Gastrointestinal issues: Difficulty having a bowel movement and dry mouth
  • Mood changes: Experiencing confusion, unusual drowsiness, or an unusual sense of well-being

These side effects are generally more common and may decrease as the body adjusts to the medication. Healthcare professionals can offer strategies to manage or reduce these effects.

Serious side effects and how to manage them

While less common, some side effects of pregabalin can be serious and may need immediate medical attention:

  • Chest pain or tightness, cold sweats: These could indicate serious cardiovascular issues
  • Muscle issues: Include aches, twitching, jerking, or weakness, which could signal underlying problems
  • Trouble breathing: Such as difficulty breathing, noisy breathing, or even loss of consciousness
  • Severe allergic reactions: Symptoms can include skin rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing
  • Mental health concerns: Depression, anxiety, suicidal thoughts or behaviors are serious side effects requiring medical consultation
  • Rhabdomyolysis: A rare but serious condition that can lead to organ damage

If you stop taking pregabalin suddenly, you might experience withdrawal symptoms. Speak with healthcare professionals for medical advice to supervise a gradual reduction in your dose.

Alternatives to pregabalin for nerve pain management

Other medications

Pregabalin is frequently used for nerve pain management, but several other medications can serve as alternatives, each with its unique mechanisms and side effects.


Often prescribed for epilepsy and migraine prevention, topiramate is also beneficial in treating nerve pain. It is a carbonic anhydrase inhibitor anticonvulsant. However, patients should be aware of its potential side effects such as drowsiness, and interactions with alcohol which can increase sleepiness.


Similar to pregabalin, gabapentin is used to treat nerve pain and partial-onset seizures. It is known for causing side effects like dizziness and drowsiness. Gabapentin enacarbil, a prodrug of gabapentin, is another option that offers similar benefits.


This medication has multiple uses including treating depression, anxiety, and nerve pain. Patients should note that withdrawal from duloxetine can be challenging, so it’s important to manage discontinuation carefully.


Amitriptyline is a tricyclic antidepressant that is effective in managing nerve pain but may lead to several side effects such as constipation, dizziness, and dry mouth. In rare cases, it can cause serious effects like abnormal heart rhythms.


Recently approved in Japan, mirogabalin is a selective oral α2δ ligand shown to be effective for peripheral neuropathic pain. It is generally well tolerated when switching from pregabalin, though monitoring for dizziness and somnolence is advised.

Non-pharmaceutical Treatments

In addition to medication, there are non-pharmaceutical approaches to managing nerve pain that can be effective, particularly when combined with medical treatments.

  • Physical therapy: Engaging in tailored exercise programs can help reduce nerve pain by strengthening the muscles around the nerves, improving mobility, and reducing pressure on the nerve
  • Acupuncture: This traditional Chinese medicine technique involves inserting thin needles into specific body points to relieve pain and improve body function
  • Transcutaneous Electrical Nerve Stimulation (TENS): A TENS unit delivers mild electrical currents to the skin, which can help to mask pain signals going to the brain
  • Lifestyle modifications: Simple changes such as maintaining a healthy weight, optimizing nutrition, and managing stress can significantly impact the severity of nerve pain
  • Cognitive Behavioral Therapy (CBT): CBT can help patients manage the psychological aspects of chronic pain, teaching strategies to cope with pain and alter pain perception

By considering these alternatives, individuals suffering from nerve pain can explore various options that may better suit them.


We have looked at pregabalin, from its mechanism of action and medical uses to the factors influencing how quickly it works for nerve pain. Understanding the reasons for how quickly the drug will work on an individual basis is key to managing expectations. Your experience with pregabalin is essential in deciding how long you should use it for treatment. Patients are encouraged to follow their doctor’s guidance closely and communicate any concerns about their pain relief or side effects.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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