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What is pregabalin used for?

What is pregabalin used for?

Navin Khosla NowPatientGreen tick
Created on 27 May 2024
Updated on 16 Jul 2024

Pregabalin is an FDA-approved prescription drug, available under the brand name Lyrica. It has proven effective in treating various medical conditions such as epilepsy, neuropathic pain, and anxiety disorders. Its unique mechanism of action and versatile therapeutic applications have made it a subject of increasing interest among healthcare professionals and patients alike.

Let’s explore how this drug can help reduce a wide range of symptoms and improve the quality of life for those with various neurological and psychological conditions.

Understanding pregabalin

Pregabalin works in the central nervous system (CNS) and is classed as an anticonvulsant. It is known for its ability to control the activity of certain neurotransmitters in the brain and spinal cord.

Epilepsy management

Pregabalin is mainly used in the treatment of epilepsy, a condition which can significantly impact an individual’s quality of life. It’s also used to treat partial-onset seizures, when taken with other medications. Pregabalin works by reducing abnormal electrical activity in the brain, helping to control and prevent seizures.

Neuropathic pain relief

Pregabalin is also a treatment option for individuals suffering from neuropathic pain. This type of pain is often associated with conditions such as diabetes (diabetic neuropathy), fibromyalgia, pain that occurs after shingles (postherpetic neuralgia) and spinal cord injuries. Pregabalin’s ability to block nerve pain signals from reaching the brain and spinal cord makes it an effective painkiller, offering relief to those living with these conditions.

Anxiety management

Pregabalin can also be used for the treatment of anxiety disorders. By controlling the release of certain neurotransmitters responsible for the feelings of anxiety, pregabalin can help reduce symptoms such as excessive worry, restlessness, and panic attacks.

This versatility in addressing both neurological and psychological conditions has made pregabalin a valuable asset in the field of mental health care.

Dosage and administration of pregabalin

Pregabalin is available in various formulations, including capsules, oral solutions, and extended-release tablets. The recommended dosage of pregabalin typically ranges from 150 to 600 milligrams each day, taken in 2 or 3 divided doses.

It is important to note that the dose of pregabalin may be adjusted based on the patient’s specific condition, age, and response to the medication. Healthcare providers often start with a lower dose and gradually increase it over the first week of treatment to minimize the risk of side effects, and to allow the patient’s body to adapt to the medication.

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time.

Patients are advised to read the medication guide, to take pregabalin at the same time(s) each day, with or without food, and to swallow the extended-release tablets whole, without cutting, chewing, or crushing them.

Potential side effects of pregabalin

The most common side effects include:

  • Drowsiness and fatigue
  • Dizziness and headaches
  • Dry mouth
  • Nausea and vomiting
  • Constipation
  • Mood changes, such as anxiety or depression
  • Weight gain

While these side effects are generally mild and tend to subside as the body adjusts to the medication, it is essential for patients to be aware of them and to report any worsening symptoms or serious side effects to their healthcare providers.

In addition to the potential side effects, there are several precautions that patients should be aware of when taking pregabalin. These include:

  • Avoiding alcohol consumption, as it can exacerbate the sedative effects of the medication
  • Refraining from driving or operating heavy machinery until the effects of the medication are known. This drug may make you dizzy or drowsy or cause blurred vision
  • Informing healthcare providers of any allergies or other medications being taken, to prevent drug interactions or allergic reactions with pregabalin. This medicine may cause serious allergic reactions, including angioedema, which can be life-threatening and require immediate medical advice
  • Informing healthcare providers of any medical conditions such as heart problems (heart failure) and kidney disease (renal impairment)
  • Informing healthcare providers if you have ever abused or been addicted to a medicine. Pregabalin has potential for addiction and patient dependence
  • Monitoring for changes in mental health, including suicidal thoughts or behaviors, and promptly reporting any such changes to a healthcare provider

Patients should also be aware that abruptly discontinuing pregabalin can lead to withdrawal symptoms, such as anxiety, insomnia, and seizures. It is essential to work closely with a healthcare provider to gradually taper the dosage when discontinuing the medication.

Pregabalin and pregnancy/breastfeeding

The use of pregabalin during pregnancy and breastfeeding requires special consideration. While some studies have suggested a slight increase in the risk of birth defects with pregabalin use during pregnancy, the benefits of the medication may outweigh the risks in certain cases, particularly for individuals with epilepsy or other conditions that require ongoing treatment.

For breastfeeding mothers, pregabalin is generally considered safe, as the amount of the medication that passes into breast milk is relatively low and unlikely to cause significant side effects in the nursing infant. However, it is still essential for breastfeeding mothers to inform their healthcare providers about their use of pregabalin and monitor their infants for any potential adverse reactions.

Pregabalin and other medications

Pregabalin can interact with various other medications, and patients must disclose all the medications they are taking, including over-the-counter drugs, herbal supplements, and vitamins, to their healthcare providers.

Some of the medications that may interact with pregabalin include:

  • Opioid pain medications
  • Antidepressants
  • Medications for anxiety or mental health conditions such as lorazepam
  • Certain diabetes medications such as rosiglitazone and pioglitazone
  • Angiotensin-converting enzyme (ACE) inhibitors

Monitoring and follow-up care

Patients taking pregabalin will typically require regular monitoring and follow-up care by healthcare providers to ensure the medication is working effectively, and to address any potential side effects or complications. Patients are encouraged to keep a close eye on their symptoms and to report any changes or concerns to them promptly.

Other therapies

While pregabalin is a highly effective treatment option for a range of medical conditions, it may not be suitable or preferred for all patients. In such cases, healthcare providers may consider alternative or complementary therapies to address the patient’s needs.

For example, in the management of neuropathic pain, other medications such as gabapentin, duloxetine, or topical treatments may be explored. In the treatment of anxiety disorders, psychotherapy, mindfulness-based interventions, or other non-pharmacological approaches may be recommended in addition to or instead of pregabalin.


Pregabalin is a versatile and effective medication that has proven its value in the treatment of a wide range of neurological and psychological conditions giving individuals living with these conditions relief and improved quality of life.

By understanding the mechanism of action, dosage and administration, potential side effects, and special considerations surrounding the use of pregabalin, healthcare providers and patients can work together to ensure the safe and effective use of this drug.


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.


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