amitriptyline
Used for Migraines and Depression
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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amitriptyline Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is amitriptyline available in?
amitriptyline is available as a 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg oral tablet.
What is amitriptyline used for?
amitriptyline is a tricyclic antidepressant and is used to treat depression.
How does amitriptyline work?
amitriptyline is a tricyclic antidepressant (TCA). It works by raising the levels of important chemicals in your brain that affect your mood, like serotonin and norepinephrine. This can help improve your mood.
How do I take amitriptyline?
amitriptyline is typically taken by mouth with a typical dose of 50 mg to 100 mg by mouth per day. The dose is either split into several smaller doses throughout the day or taken as a single dose before bedtime. The maximum recommended dose is 150 mg per day. Children 12 to 17 years old and adults 65 years and older: The typical starting dose is 10 mg by mouth three times per day along with 20 mg at bedtime.
Is it safe for me to take amitriptyline?
amitriptyline is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication during the acute recovery phase following myocardial infarction and in the presence of acute congestive heart failure. You should also avoid it if you have taken an MAOI within the past 14 days.
amitriptyline Common Side Effects
Common side effects of amitriptyline include:
- Sleepiness
- Dizziness
- Weakness
- Fatigue
- Headache
- Dry mouth
- Nausea
- Vomiting
- Constipation
- Weight gain
amitriptyline Serious Side Effects
Serious side effects are rare with amitriptyline. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Heart attack: chest pain, cold sweats, left arm pain, difficulty breathing
- Stroke: sudden numbness, weakness, confusion, or difficulty talking
- Serious allergic reaction: difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, dizziness, swelling in the face or tongue
Effects of other drugs, drug classes and over-the-counter products on amitriptyline
The following medications may interact with amitriptyline:
- Do not use amitriptyline within 14 days of use of MAOIs (Monoamine oxidase inhibitor)
- Avoid using amitriptyline with drugs that can increase QTc, such as astemizole, cisapride, disopyramide, ibutilide, indapamide, pentamidine, pimozide, procainamide, quinidine, sotalol, terfenadine which can lead to cardiac problems, including arrhythmias
- When used along with amitriptyline, some drugs may cause an increase in serotonin concentrations; such drugs include isocarboxazid, phenelzine, procarbazine, safinamide, selegiline, tranylcypromine, sertraline. These drugs can cause serotonin syndrome
- Omeprazole is metabolized by CYP2C19; it also inhibits CYP2C19 and can lead to delirium if administered with amitriptyline
Who makes amitriptyline?
Various FDA-approved generic manufacturers
Is amitriptyline safe in pregnancy?
It is not known if amitriptyline will harm your unborn baby. If you become pregnant while receiving amitriptyline, talk to your healthcare provider.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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