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Is the cost of your duloxetine too expensive?

You may qualify for programs where you can pay as little as $0 per fill, subject to income and insurance status.

This content is intended for US audiences only

NowPatient offers cost effective access to duloxetine for everyone including those who are uninsured, those who have commercial insurance as well as those who are enrolled into state or federal programs like Medicaid, Medicare Part D, full Low Income Subsidy (LIS, “Extra Help”), TRICARE or Veterans (VA) Benefits.

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Table of contents
OverviewWhat can I do if I am commercially insured but cannot afford my duloxetine?What can I do if I am uninsured and cannot afford my duloxetine?What can I do if I am insured with Medicare and cannot afford my duloxetine?Am I eligible for the Rx Advantage Card and how much does duloxetine cost without insurance?What will my out-of-pocket cost be for duloxetine when using the Rx Advantage Card?Is it legal for me to pay cash for duloxetine even though I have insurance?Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?Does the Rx Advantage Card work with Commercial Insurance?How do I check prices for duloxetine and how do I use the Rx Advantage Card?Do I need to pay for the Rx Advantage Card?Is there a duloxetine co-pay program?Is there a duloxetine Patient Assistance Program (PAP)?What should I do if I take too much duloxetine?What are the benefits of NowPatient?What is generic duloxetine?FDA approval of duloxetineActive ingredient of duloxetineUS brand name of duloxetine and manufacturerUK brand name of duloxetine and manufacturerPrescription requirement for duloxetineAvailability of duloxetine in the UK with NHS prescriptionConditions treated by duloxetineHow does duloxetine work?Forms of duloxetine availableDosage of duloxetineDirections for duloxetine useWarnings and precautions for duloxetineDrug interactionsUse of duloxetine if pregnant or planning pregnancyPossible side effects of duloxetineSimilar drugs to duloxetineSourcesPeople also asked
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Medically reviewed by Navin Khosla, BPharm and written by Rajive Patel, BPharm - Updated on 25 Jan 2024
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What can I do if I am commercially insured but cannot afford my duloxetine?

If you are commercially insured and you cannot afford your copay or co-insurance you can opt for purchasing duloxetine outside of your plan using the Rx Advantage card, with costs that are usually lower than a typical plan copay. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

If you cannot afford the cash price possibly due to income constraints, then there is the option of applying to state assistance programs like Medicaid. Often, you may be able to receive your duloxetine without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am uninsured and cannot afford my duloxetine?

If you cannot afford the cash price of duloxetine using the Rx Advantage card then there is the option of applying to state programs like Medicaid. Often, you may be able to receive your duloxetine without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am insured with Medicare and cannot afford my duloxetine?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have a number of options:

Option

Savings Information

RX ADVANTAGE CARD

You can use the Rx Advantage to purchase the medication outside of your plan at prices that may be lower than you copay or co-insurance element. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

LOW INCOME SUBSIDY

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

MEDICAID

Alternatively, you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does duloxetine cost without insurance?

Our website gives savings options to customers who wish to purchase duloxetine, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for duloxetine when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for duloxetine using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket duloxetine cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket duloxetine cash price you pay can be typically cheaper than your plan copay.

How do I check prices for duloxetine and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your duloxetine Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a duloxetine co-pay program?

Generic medications like duloxetine do not have co-pay card savings options. A Copay program, if available, would normally be for the brand name version of duloxetine. You can search the brand name of duloxetine and check to see if a co-pay program exists. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

Is there a duloxetine Patient Assistance Program (PAP)?

Generic medications like duloxetine do not have PAP savings options. A Patient assistance program, if available would normally be for the brand name version of duloxetine. You can search the brand name of duloxetine and check to see if a co-PAP exists. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What should I do if I take too much duloxetine?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using duloxetine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much duloxetine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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NowPatient is more than just prescriptions and online pharmacy services. When you join you get access to a range of health services for FREE making NowPatient a perfect companion for helping you lead a healthier life. Join now by either signing up for an account online or downloading the app from the App Store today.

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What is generic duloxetine?

Generic duloxetine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of duloxetine

Duloxetine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain.

Active ingredient of duloxetine

The active ingredient of duloxetine is duloxetine hydrochloride.

US brand name of duloxetine and manufacturer

Duloxetine is available in the US under the brand name Cymbalta. The manufacturer is Eli Lilly and Company.

UK brand name of duloxetine and manufacturer

In the UK, duloxetine is available under various brand names, including Cymbalta and Yentreve. The manufacturer may vary depending on the brand name.

Prescription requirement for duloxetine

A prescription (Rx) is required for duloxetine in both the US and the UK.

Availability of duloxetine in the UK with NHS prescription

Duloxetine is available in the UK with an NHS prescription.

Conditions treated by duloxetine

Duloxetine is a medication primarily used to treat major depressive disorder (MDD), and anxiety disorders. It belongs to a class of medications known as selective serotonin and norepinephrine reuptake inhibitors (SNRIs), which increase serotonin and norepinephrine levels in the brain.

Duloxetine is also approved for treating fibromyalgia, a condition characterized by chronic pain and tenderness in muscles, joints, and soft tissues. It can help reduce the pain associated with fibromyalgia and improve overall functioning.

Duloxetine is commonly prescribed for the management of diabetic peripheral neuropathy, a type of nerve damage caused by diabetes. It can help alleviate the pain, tingling, and numbness in the hands and feet that are often experienced by individuals with this condition.

Duloxetine is utilized in the treatment of chronic musculoskeletal pain, such as osteoarthritis-related pain and chronic back pain. It can provide relief by altering the way pain signals are processed in the brain and spinal cord.

Duloxetine is also sometimes used to treat stress urinary incontinence.

How does duloxetine work?

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood, reduce pain, and relieve anxiety symptoms.

Forms of duloxetine available

Duloxetine is available in the form of oral capsules.

Dosage of duloxetine

The dosage of duloxetine may vary depending on the specific condition being treated. It is important to follow the recommended dosage instructions provided by the healthcare provider.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Directions for duloxetine use

Duloxetine should be taken exactly as directed by the healthcare provider. The specific instructions may include the frequency of use, timing of administration, and any necessary precautions.

Warnings and precautions for duloxetine

  • Duloxetine may have certain risks and potential adverse effects. Discussing these with a healthcare provider before starting the medication is important
  • Duloxetine may interact with other medications, so it is important to inform the healthcare provider about all the medications being taken including over-the-counter medication and herbal supplements such as St. John’s Wort

Drug interactions

Here are some examples of drug interactions associated with duloxetine:

  • Monoamine oxidase inhibitors such as linezolid or methylene blue can increase the risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and seizures. It is important to allow a minimum of 14 days between discontinuing an MAOI and starting duloxetine
  • Duloxetine can increase the levels of serotonin in the brain, so combining it with other serotonergic drugs such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and certain migraine medications can increase the risk of serotonin syndrome. It is important to inform your healthcare provider of all the medications you are taking to avoid any potential interactions
  • CYP1A2 inhibitors can increase the levels of duloxetine in the body, leading to a higher risk of side effects. Some examples of CYP1A2 inhibitors include fluvoxamine, ciprofloxacin, and enoxacin. Your healthcare provider may need to adjust your duloxetine dosage if you are taking any of these medications
  • CYP2D6 inhibitors can increase the levels of duloxetine in the body, potentially leading to an increased risk of side effects. Examples of CYP2D6 inhibitors include fluoxetine, paroxetine, and quinidine. Your healthcare provider may need to adjust your duloxetine dosage if you are taking any of these medications
  • Duloxetine may increase the risk of bleeding when taken with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or blood thinners such as warfarin. It is important to monitor for signs of bleeding, such as easy bruising or bleeding gums, if you are taking duloxetine with these medications
  • Drinking alcohol while taking duloxetine can increase the risk of liver damage and other side effects. It is generally recommended to avoid alcohol while taking this medication

Use of duloxetine if pregnant or planning pregnancy

The use of duloxetine during pregnancy and breastfeeding should be discussed with a healthcare provider. Duloxetine enters breast milk. Using duloxetine is not recommended during lactation/pregnancy unless the benefits greatly outweigh the risks.

Possible side effects of duloxetine

In clinical trials common side effects of duloxetine may include nausea, dry mouth, drowsiness, constipation, and decreased appetite. Serious side effects are rare but can occur. Promptly report any concerning symptoms to a healthcare provider.

Here are some common side effects associated with duloxetine:

  • Nausea may range from mild discomfort to severe queasiness. Taking the medication with food can help alleviate this symptom
  • Duloxetine can cause a decrease in salivary flow, leading to a dry mouth. This may result in a persistent thirst and an increased risk of dental problems
  • Duloxetine can sometimes cause drowsiness or dizziness, especially when starting the medication or increasing the dosage. It is important to avoid activities that require alertness, such as driving or operating machinery, until you know how duloxetine affects you
  • Some people may experience changes in sexual desire, difficulty achieving orgasm, or erectile dysfunction while taking duloxetine. These side effects may be temporary or persistent
  • Duloxetine may cause weight gain or weight loss in some individuals. It is important to monitor your weight while taking this medication and discuss any significant changes with your healthcare provider
  • Duloxetine may raise blood pressure in some individuals. Regular blood pressure monitoring is recommended while taking this medication
  • Sudden discontinuation of duloxetine can lead to withdrawal symptoms such as dizziness, nausea, headache, irritability, and electric shock-like sensations. It is important to gradually decrease the dosage under the guidance of a healthcare professional
  • Like many antidepressant medications, duloxetine may increase the risk of suicidal thoughts or behavior, especially in young adults. It is important to closely monitor for any changes in mood or behavior while taking this medication

It is essential to discuss any side effects or concerns with your healthcare provider. They can provide guidance and make any necessary adjustments to your treatment plan.

Similar drugs to duloxetine

Other SNRI medications, such as venlafaxine and desvenlafaxine, may be used as alternatives for the treatment of major depressive disorder and generalized anxiety disorder.

Sources

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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