Duloxetine Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Duloxetine Delayed Release (DR)
    Generic for Cymbalta
    30 delayed release capsules $4.2 USD
    Save $115.50
  3. Duloxetine Delayed Release (DR)
    Generic for Cymbalta
    30 delayed release capsules $4.5 USD
    Save $115.20
  4. Duloxetine Delayed Release (DR)
    Generic for Cymbalta
    30 delayed release capsules $5.1 USD
    Save $114.60
  5. Duloxetine Delayed Release (DR)
    Generic for Cymbalta
    360 delayed release capsules $30.3 USD
    Save $1406.10
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Do you need a prescription for duloxetine?

Yes, duloxetine is only available with a valid physician Rx.

How much is duloxetine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase duloxetine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for duloxetine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a duloxetine savings card?

Yes. Save up to 90% on your duloxetine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a duloxetine coupon provider in the US?

No. Now Patient does not provide duloxetine coupons or FREE duloxetine samples.

Do you accept commercial, Medicare or Medicaid coverage for duloxetine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much duloxetine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using duloxetine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much duloxetine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic duloxetine?

Generic duloxetine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of duloxetine

Duloxetine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, diabetic peripheral neuropathy, and chronic musculoskeletal pain.

Active ingredient of duloxetine

The active ingredient of duloxetine is duloxetine hydrochloride.

US brand name of duloxetine and manufacturer

Duloxetine is available in the US under the brand name Cymbalta. The manufacturer is Eli Lilly and Company.

UK brand name of duloxetine and manufacturer

In the UK, duloxetine is available under various brand names, including Cymbalta and Yentreve. The manufacturer may vary depending on the brand name.

Prescription requirement for duloxetine

A prescription (Rx) is required for duloxetine in both the US and the UK.

Availability of duloxetine in the UK with NHS prescription

Duloxetine is available in the UK with an NHS prescription.

Conditions treated by duloxetine

Duloxetine is a medication primarily used to treat major depressive disorder (MDD), and anxiety disorders. It belongs to a class of medications known as selective serotonin and norepinephrine reuptake inhibitors (SNRIs), which increase serotonin and norepinephrine levels in the brain.

Duloxetine is also approved for treating fibromyalgia, a condition characterized by chronic pain and tenderness in muscles, joints, and soft tissues. It can help reduce the pain associated with fibromyalgia and improve overall functioning.

Duloxetine is commonly prescribed for the management of diabetic peripheral neuropathy, a type of nerve damage caused by diabetes. It can help alleviate the pain, tingling, and numbness in the hands and feet that are often experienced by individuals with this condition.

Duloxetine is utilized in the treatment of chronic musculoskeletal pain, such as osteoarthritis-related pain and chronic back pain. It can provide relief by altering the way pain signals are processed in the brain and spinal cord.

Duloxetine is also sometimes used to treat stress urinary incontinence.

How does duloxetine work?

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood, reduce pain, and relieve anxiety symptoms.

Forms of duloxetine available

Duloxetine is available in the form of oral capsules.

Dosage of duloxetine

The dosage of duloxetine may vary depending on the specific condition being treated. It is important to follow the recommended dosage instructions provided by the healthcare provider.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Directions for duloxetine use

Duloxetine should be taken exactly as directed by the healthcare provider. The specific instructions may include the frequency of use, timing of administration, and any necessary precautions.

Warnings and precautions for duloxetine

  • Duloxetine may have certain risks and potential adverse effects. Discussing these with a healthcare provider before starting the medication is important
  • Duloxetine may interact with other medications, so it is important to inform the healthcare provider about all the medications being taken including over-the-counter medication and herbal supplements such as St. John’s Wort

Drug interactions

Here are some examples of drug interactions associated with duloxetine:

  • Monoamine oxidase inhibitors such as linezolid or methylene blue can increase the risk of a serious condition called serotonin syndrome. Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and seizures. It is important to allow a minimum of 14 days between discontinuing an MAOI and starting duloxetine
  • Duloxetine can increase the levels of serotonin in the brain, so combining it with other serotonergic drugs such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and certain migraine medications can increase the risk of serotonin syndrome. It is important to inform your healthcare provider of all the medications you are taking to avoid any potential interactions
  • CYP1A2 inhibitors can increase the levels of duloxetine in the body, leading to a higher risk of side effects. Some examples of CYP1A2 inhibitors include fluvoxamine, ciprofloxacin, and enoxacin. Your healthcare provider may need to adjust your duloxetine dosage if you are taking any of these medications
  • CYP2D6 inhibitors can increase the levels of duloxetine in the body, potentially leading to an increased risk of side effects. Examples of CYP2D6 inhibitors include fluoxetine, paroxetine, and quinidine. Your healthcare provider may need to adjust your duloxetine dosage if you are taking any of these medications
  • Duloxetine may increase the risk of bleeding when taken with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or blood thinners such as warfarin. It is important to monitor for signs of bleeding, such as easy bruising or bleeding gums, if you are taking duloxetine with these medications
  • Drinking alcohol while taking duloxetine can increase the risk of liver damage and other side effects. It is generally recommended to avoid alcohol while taking this medication

Use of duloxetine if pregnant or planning pregnancy

The use of duloxetine during pregnancy and breastfeeding should be discussed with a healthcare provider. Duloxetine enters breast milk. Using duloxetine is not recommended during lactation/pregnancy unless the benefits greatly outweigh the risks.

Possible side effects of duloxetine

In clinical trials common side effects of duloxetine may include nausea, dry mouth, drowsiness, constipation, and decreased appetite. Serious side effects are rare but can occur. Promptly report any concerning symptoms to a healthcare provider.

Here are some common side effects associated with duloxetine:

  • Nausea may range from mild discomfort to severe queasiness. Taking the medication with food can help alleviate this symptom
  • Duloxetine can cause a decrease in salivary flow, leading to a dry mouth. This may result in a persistent thirst and an increased risk of dental problems
  • Duloxetine can sometimes cause drowsiness or dizziness, especially when starting the medication or increasing the dosage. It is important to avoid activities that require alertness, such as driving or operating machinery, until you know how duloxetine affects you
  • Some people may experience changes in sexual desire, difficulty achieving orgasm, or erectile dysfunction while taking duloxetine. These side effects may be temporary or persistent
  • Duloxetine may cause weight gain or weight loss in some individuals. It is important to monitor your weight while taking this medication and discuss any significant changes with your healthcare provider
  • Duloxetine may raise blood pressure in some individuals. Regular blood pressure monitoring is recommended while taking this medication
  • Sudden discontinuation of duloxetine can lead to withdrawal symptoms such as dizziness, nausea, headache, irritability, and electric shock-like sensations. It is important to gradually decrease the dosage under the guidance of a healthcare professional
  • Like many antidepressant medications, duloxetine may increase the risk of suicidal thoughts or behavior, especially in young adults. It is important to closely monitor for any changes in mood or behavior while taking this medication

It is essential to discuss any side effects or concerns with your healthcare provider. They can provide guidance and make any necessary adjustments to your treatment plan.

Similar drugs to duloxetine

Other SNRI medications, such as venlafaxine and desvenlafaxine, may be used as alternatives for the treatment of major depressive disorder and generalized anxiety disorder.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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