Used for Anxiety and Depression

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duloxetine Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is duloxetine available in?

What dosages is duloxetine available in?

duloxetine is available as a 20 mg, 30 mg, and 60 mg delayed-release oral capsule.

What is duloxetine used for?

What is duloxetine used for?

duloxetine is an SNRI used for major depressive disorder in adults, generalized anxiety disorder in people age 7 years and older, diabetic neuropathy (nerve pain caused by high blood sugar) in adults, fibromyalgia in adults (brand duloxetine approved for people age 13 years and older), and long-term muscle pain in adults.

How does duloxetine work?

How does duloxetine work?

duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI). It’s thought to help improve mood and pain by raising the level of chemicals called serotonin and norepinephrine in your brain.

How do I take duloxetine?

How do I take duloxetine?

duloxetine is typically ranges in dose from 30 mg to 60 mg by mouth once daily. Sometimes, your physician might divide your total daily dose into two smaller doses to be taken twice daily.

Is it safe for me to take duloxetine?

Is it safe for me to take duloxetine?

duloxetine is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have taken an MAOI within the past 14 days or are currently being treated with linezolid or intravenous methylene blue.

duloxetine Common Side Effects

duloxetine Common Side Effects

Common side effects of duloxetine include:

  • Nausea
  • Headache
  • Dry mouth
  • Drowsiness
  • Trouble sleeping
  • Feeling tired
  • Constipation
  • Dizziness
  • Diarrhea
  • Low appetite
  • Excessive sweating
  • Stomach pain
duloxetine Serious Side Effects

duloxetine Serious Side Effects

Serious side effects are rare with duloxetine. Contact your healthcare provider immediately if you experience any of the following.

  • Suicidal thoughts or behaviors
  • Serotonin syndrome: restlessness, fast heartbeat, diarrhea, nausea, vomiting, feeling very warm, abnormal eye movements, loss of balance, fever, muscle spasms, tremors
  • Severe skin reaction: blisters, peeling rash, sores
  • Liver damage: nausea, vomiting, loss of appetite, severe stomach pain, yellowing of skin or eyes
Effects of other drugs, drug classes and over-the-counter products on duloxetine

Effects of other drugs, drug classes and over-the-counter products on duloxetine

The following medications may interact with duloxetine:

  • Potent inhibitors of CYP1A2 should be avoided
  • Potent inhibitors of CYP2D6 may increase duloxetine concentrations
Who makes duloxetine?

Who makes duloxetine?

Various FDA-approved generic manufacturers

Is duloxetine safe in pregnancy?

Is duloxetine safe in pregnancy?

duloxetine use during the third trimester use may increase risk for symptoms of poor adaptation (respiratory distress, temperature instability, feeding
difficulty, hypotonia, tremor, irritability) in the unborn baby. There is a pregnancy exposure registry that monitors the pregnancy outcomes in women exposed to antidepressants, including duloxetine, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Antidepressants at 1-866-961-2388 or online at
women’s health


What to do if you missed your duloxetine dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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