CYMBALTA
Used for Anxiety and Depression
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Manufactured by Eli Lilly & Company
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CYMBALTA Uses, Side Effects, Interactions, Warnings & Dosing
What is CYMBALTA?
CYMBALTA is the brand name of duloxetine and is available as a delayed-release oral capsule.
What dosages is CYMBALTA available in?
CYMBALTA is available as a 20 mg, 30 mg, and 60 mg delayed-release oral capsule.
What is CYMBALTA used for?
CYMBALTA is an SNRI used for major depressive disorder in adults, generalized anxiety disorder in people age 7 years and older, diabetic neuropathy (nerve pain caused by high blood sugar) in adults, fibromyalgia in adults (brand Cymbalta approved for people age 13 years and older), and long-term muscle pain in adults.
How does CYMBALTA work?
CYMBALTA is a serotonin and norepinephrine reuptake inhibitor (SNRI). It’s thought to help improve mood and pain by raising the level of chemicals called serotonin and norepinephrine in your brain.
How do I take CYMBALTA?
CYMBALTA is typically ranges in dose from 30 mg to 60 mg by mouth once daily. Sometimes, your physician might divide your total daily dose into two smaller doses to be taken twice daily.
Is it safe for me to take CYMBALTA?
CYMBALTA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have taken an MAOI within the past 14 days or are currently being treated with linezolid or intravenous methylene blue.
CYMBALTA Common Side Effects
Common side effects of CYMBALTA include:
- Nausea
- Headache
- Dry mouth
- Drowsiness
- Trouble sleeping
- Feeling tired
- Constipation
- Dizziness
- Diarrhea
- Low appetite
- Excessive sweating
- Stomach pain
CYMBALTA Serious Side Effects
Serious side effects are rare with CYMBALTA. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Serotonin syndrome: restlessness, fast heartbeat, diarrhea, nausea, vomiting, feeling very warm, abnormal eye movements, loss of balance, fever, muscle spasms, tremors
- Severe skin reaction: blisters, peeling rash, sores
- Liver damage: nausea, vomiting, loss of appetite, severe stomach pain, yellowing of skin or eyes
Effects of other drugs, drug classes and over-the-counter products on CYMBALTA
The following medications may interact with CYMBALTA:
- Potent inhibitors of CYP1A2 should be avoided
- Potent inhibitors of CYP2D6 may increase CYMBALTA concentrations
Who makes CYMBALTA?
Eli Lilly & Company
Is CYMBALTA safe in pregnancy?
CYMBALTA use during the third trimester use may increase risk for symptoms of poor adaptation (respiratory distress, temperature instability, feeding
difficulty, hypotonia, tremor, irritability) in the unborn baby. There is a pregnancy exposure registry that monitors the pregnancy outcomes in women exposed to antidepressants, including CYMBALTA, during pregnancy. Healthcare providers are encouraged to register patients by contacting the National Pregnancy Registry for Antidepressants at 1-866-961-2388 or online at
women’s health
What to do if you missed your CYMBALTA dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What is Cymbalta best used for?
How does Cymbalta make you feel?
Is Cymbalta better at night or day?
Is it better to take Cymbalta at night?
Which is better Xanax or Cymbalta?
Is Cymbalta calming?
How quickly will Cymbalta work?
What is the number one side effect of Cymbalta?
Does Cymbalta make you gain weight?
Why is Cymbalta taken at night?
Why is Cymbalta so hard to get off of?
How fast do you lose weight on Cymbalta?
What organ does duloxetine affect?
What are the pros and cons of taking Cymbalta?
Is Cymbalta a high risk medication?
How does Cymbalta make a person feel?
What is brain zaps from Cymbalta?
Is Cymbalta hard on the liver or kidneys?
Is Cymbalta hard on your heart?
How common is liver damage with Cymbalta?
What does Cymbalta do in the body?
Do Cymbalta make you gain weight?
How will Cymbalta make you feel?
Is it better to take Cymbalta in the morning or at night?
How long does it take for Cymbalta to kick in?
Is Cymbalta and gabapentin the same thing?
Is Cymbalta considered a narcotic?
What is better Cymbalta or Xanax?
What should I avoid while taking Cymbalta?
Can I drink caffeine on Cymbalta?
Do you gain weight on Cymbalta?
Why should I take Cymbalta at night?
Should I take my Cymbalta at night or in the morning?
Why can't you take ibuprofen with Cymbalta?
Is it OK to have one drink on Cymbalta?
Can I have an occasional drink while on Cymbalta?
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