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Is the cost of your progesterone too expensive?

You may qualify for programs where you can pay as little as $0 per fill, subject to income and insurance status.

This content is intended for US audiences only

NowPatient offers cost effective access to progesterone for everyone including those who are uninsured, those who have commercial insurance as well as those who are enrolled into state or federal programs like Medicaid, Medicare Part D, full Low Income Subsidy (LIS, “Extra Help”), TRICARE or Veterans (VA) Benefits.

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Table of contents
OverviewWhat can I do if I am commercially insured but cannot afford my progesterone?What can I do if I am uninsured and cannot afford my progesterone?What can I do if I am insured with Medicare and cannot afford my progesterone?Am I eligible for the Rx Advantage Card and how much does progesterone cost without insurance?What will my out-of-pocket cost be for progesterone when using the Rx Advantage Card?Is it legal for me to pay cash for progesterone even though I have insurance?Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?Does the Rx Advantage Card work with Commercial Insurance?How do I check prices for progesterone and how do I use the Rx Advantage Card?Do I need to pay for the Rx Advantage Card?Is there a progesterone co-pay program?Is there a progesterone Patient Assistance Program (PAP)?What should I do if I take too much progesterone?What are the benefits of NowPatient?US brand name of progesterone and manufacturerUK brand name of progesterone and manufacturerIs progesterone available in the UK on the NHS?Prescription requirement for progesteroneActive ingredient of progesterone and mechanism of actionUses of progesteroneForms of progesteroneDosage of progesteronePrecautions and warnings for progesteroneSide effects of progesteroneDrug interactionsSourcesPeople also asked
Navin Khosla NowPatientGreen tick
Medically reviewed by Navin Khosla, BPharm and written by Rajive Patel, BPharm - Updated on 25 Jan 2024
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What can I do if I am commercially insured but cannot afford my progesterone?

If you are commercially insured and you cannot afford your copay or co-insurance you can opt for purchasing progesterone outside of your plan using the Rx Advantage card, with costs that are usually lower than a typical plan copay. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

If you cannot afford the cash price possibly due to income constraints, then there is the option of applying to state assistance programs like Medicaid. Often, you may be able to receive your progesterone without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am uninsured and cannot afford my progesterone?

If you cannot afford the cash price of progesterone using the Rx Advantage card then there is the option of applying to state programs like Medicaid. Often, you may be able to receive your progesterone without any costs at all. You can check Medicaid eligibility in your state by following this link HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application.

What can I do if I am insured with Medicare and cannot afford my progesterone?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have a number of options:

Option

Savings Information

RX ADVANTAGE CARD

You can use the Rx Advantage to purchase the medication outside of your plan at prices that may be lower than you copay or co-insurance element. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

LOW INCOME SUBSIDY

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

MEDICAID

Alternatively, you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does progesterone cost without insurance?

Our website gives savings options to customers who wish to purchase progesterone, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for progesterone when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for progesterone using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket progesterone cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket progesterone cash price you pay can be typically cheaper than your plan copay.

How do I check prices for progesterone and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your progesterone Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a progesterone co-pay program?

Generic medications like progesterone do not have co-pay card savings options. A Copay program, if available, would normally be for the brand name version of progesterone. You can search the brand name of progesterone and check to see if a co-pay program exists. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

Is there a progesterone Patient Assistance Program (PAP)?

Generic medications like progesterone do not have PAP savings options. A Patient assistance program, if available would normally be for the brand name version of progesterone. You can search the brand name of progesterone and check to see if a co-PAP exists. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What should I do if I take too much progesterone?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using progesterone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much progesterone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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US brand name of progesterone and manufacturer

Progesterone is available in the US under various brand names, including Prometrium, Crinone, and Endometrin. It is manufactured by multiple pharmaceutical companies.

UK brand name of progesterone and manufacturer

Progesterone is available in the UK under various brand names, including Utrogestan and Cyclogest. It is manufactured by different pharmaceutical companies.

Is progesterone available in the UK on the NHS?

Yes, progesterone is available on the NHS in the UK.

Prescription requirement for progesterone

Progesterone is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of progesterone and mechanism of action

Progesterone is an endogenous steroid hormone. Progesterone production happens in the adrenal glands and also ovaries.  It plays a vital role in the female reproductive system. It is normally secreted by the corpus luteum in the ovary during the second half of the menstrual cycle (normal menstruation).  It is involved in the regulation of the menstrual cycle and is essential for maintaining pregnancy. Progesterone binds to progesterone receptors in the body, influencing various physiological processes.
Progesterone plays several important roles in the body:

  • Menstrual cycle: During the menstrual cycle, progesterone helps to regulate the lining of the uterus. It prepares the endometrium (the lining of the uterus) to receive a fertilized egg. If a fertilized egg does not attach to the endometrium, progesterone levels drop and menstrual bleeding occurs
  • Pregnancy: If a fertilized egg does attach to the endometrium (meaning pregnancy has occurred), progesterone helps maintain the endometrium to support the ongoing pregnancy. Progesterone is secreted by the placenta, during the later phase of pregnancy

As a medication, progesterone is used in several ways, including:

  • Hormone replacement therapy (HRT): For women who have passed menopause, it is often used as part of HRT, usually in combination with estrogen. The progesterone can help counteract the risk of uterine cancer that can come with taking estrogen alone
  • Infertility and pregnancy support: Progesterone can also be used in fertility treatments, to help prepare the endometrium for implantation of a fertilized egg, and to support early pregnancy
  • Birth control: Progesterone (or more often, a synthetic version called a progestin) is also a common component of many forms of hormonal birth control, including oral contraceptive birth control pills, intrauterine devices (IUDs), and implants. In this context, it works primarily by preventing ovulation and by making the endometrium less hospitable to a fertilized egg

Uses of progesterone

Progesterone is used for various purposes, including:

  • Menopausal symptoms and hormone replacement therapy (HRT): Progesterone is often used in combination with estrogen as part of HRT to manage symptoms of menopause, such as hot flashes and night sweats. Progesterone helps to counteract the effect of estrogen on the uterus, reducing the risk of endometrial hyperplasia and possibly endometrial cancer
  • Amenorrhea: This is a condition where menstrual periods stop or do not begin. Progesterone can be used to stimulate menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body
  • Abnormal uterine bleeding: Progesterone is often used to manage this condition, especially when it’s due to hormonal imbalance
  • Infertility treatments: Progesterone can be used as part of assisted reproductive technology procedures such as in-vitro fertilization (IVF). It can help prepare the lining of the uterus for embryo implantation
  • Prevention of premature birth: In certain cases where a woman has a history of delivering too early, progesterone can be used to help prevent another premature birth
  • Contraception: Progesterone, often in a synthetic form called a progestin, is a common ingredient in many forms of hormonal birth control, including pills, patches, injections, intrauterine devices (IUDs), and implants

Remember to always consult with a healthcare provider for personal medical advice. Progesterone may have side effects, interactions, and may not be suitable for everyone. It should always be used under the supervision of a healthcare provider

Forms of progesterone

  • Oral: Progesterone can be taken by mouth in the form of capsules, often used for hormone replacement therapy in menopausal women and sometimes in fertility treatments
  • Injectable: Progesterone can be injected directly into the muscle or under the skin. This form is often used in fertility treatments and to prevent preterm birth in certain high-risk pregnancies
  • Topical: Progesterone can be used topically as a cream or gel. Topical progesterone is often used for hormone replacement therapy, and the gel form can also be used in fertility treatments
  • Vaginal: Progesterone can be inserted into the vagina as a gel, tablet, or suppository. This form is often used in fertility treatments and to supplement progesterone in early pregnancy
  • Intrauterine device (IUD): Some IUDs release a form of progesterone (progestin) to prevent pregnancy
  • Implants and injections: Some forms of long-term birth control involve implants or injections that slowly release a form of progesterone (progestin)

Dosage of progesterone

The dosage of progesterone can vary widely depending on the reason it’s being used, the specific formulation, and individual patient factors. As a result, it’s crucial to follow the directions given by your healthcare provider or pharmacist. Below are some general dosing guidelines for different uses of progesterone:

  • Menopausal symptoms / hormone replacement therapy (HRT): For oral progesterone, the typical dose is 200 mg taken at bedtime for 12 to 14 consecutive days per 28-day cycle. Topical doses can vary but are often around 20 mg per day
  • Amenorrhea and abnormal uterine bleeding: For these conditions, the typical oral dose of progesterone is 400 mg per day for 10 days
  • Assisted reproductive technology (ART): For use in ART like in-vitro fertilization (IVF), progesterone is often given as an intramuscular injection at a dose of 50 to 100 mg per day, or as a vaginal gel, insert, or suppository at a dose of 90 to 100 mg per day
  • Prevention of premature birth: In women who have previously had a premature birth, a dose of 250 mg of progesterone is typically given as an intramuscular injection once a week, starting between 16 and 20 weeks of pregnancy and continuing until 37 weeks of pregnancy

Precautions and warnings for progesterone

  • Allergic reactions: Some people may have an allergic reaction to progesterone. If you have any signs of an allergic reaction such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, get emergency medical help immediately
  • Cardiovascular disorders: Progesterone can cause fluid retention, which can exacerbate conditions like heart failure, kidney disease, or high blood pressure. People with these conditions should use progesterone with caution
  • Liver disease: Progesterone should be used with caution in people with liver disease, as the liver is involved in metabolizing the drug
  • Breast cancer and Other Hormone-Sensitive Cancers: Because progesterone is a hormone, it can potentially stimulate the growth of certain hormone-sensitive cancers. People with a personal or family history of hormone-sensitive cancers (such as breast cancer or ovarian cancer) should discuss the risks and benefits with their doctor before using progesterone
  • Blood clots: Progesterone, especially when taken with estrogen, can increase the risk of blood clots. The risk is higher in women who smoke or who have a personal or family history of blood clots
  • Mental health disorders: Progesterone can cause mood changes and can potentially exacerbate mental health conditions like depression
  • Pregnancy and breastfeeding: While progesterone is often used during pregnancy to support the pregnancy or prevent premature birth, its use should always be guided by a healthcare provider. Breastfeeding while using progesterone should also be discussed with a healthcare provider, as small amounts can pass into breast milk

Side effects of progesterone

Common side effects may include:

  • Drowsiness or dizziness
  • Headache
  • Breast pain or breast tenderness
  • Mood changes or depression
  • Abdominal pain or cramping
  • Nausea, bloating or diarrhea
  • Joint or muscle pain

Serious side effects are less common, but they can occur. These can include:

  • Chest pain or discomfort
  • Difficulty breathing or shortness of breath
  • Pain in the arm, back, neck, or jaw
  • Unusual or sudden body or facial swelling
  • Severe headache or vomiting, dizziness or fainting, disturbances of vision or speech, or weakness or numbness in an arm or leg (possible signs of a stroke)
  • Severe abdominal pain, yellowing of the skin or eyes, dark urine (possible signs of a liver problem)
  • Unusual vaginal bleeding

Drug interactions

Potential drug interactions with progesterone include:

  • Rifampin and other antibiotics or antifungal medications: Some antibiotics and antifungal medications can make progesterone less effective, potentially leading to a return of symptoms or, in the case of contraceptive use, an increased risk of pregnancy
  • Certain seizure medications: Medications like phenytoin, carbamazepine, and phenobarbital can decrease the effectiveness of progesterone
  • St. John’s Wort: This herbal supplement can reduce the effectiveness of progesterone
  • Anticoagulants or blood thinners: Progesterone may increase the risk of blood clotting, which can be especially problematic if you are also taking a blood thinner like warfarin
  • Other hormonal medications: Progesterone can interact with other hormonal medications, including other forms of hormone therapy and hormonal contraceptives. This can affect the balance of hormones in your body and potentially increase the risk of side effects
  • Certain HIV medications: Some medications used to treat HIV can decrease the levels of progesterone in your body, potentially making it less effective.

Sources

  • Prometrium (Progesterone) Prescribing Information – Merck Sharp & Dohme Corp.
  • Utrogestan (Progesterone) Summary of Product Characteristics – electronic Medicines Compendium (eMC).
  • Progesterone – MedlinePlus.

Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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