ProgesteronePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Progesterone
    Generic for Prometrium
    30 capsules $6.6 USD
    Save $13.80
  3. Progesterone
    Generic for Prometrium
    45 capsules $9.3 USD
    Save $21.30
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Do you need a prescription for progesterone?

Yes, progesterone is only available with a valid physician Rx.

How much is progesterone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase progesterone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for progesterone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a progesterone savings card?

Yes. Save up to 90% on your progesterone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a progesterone coupon provider in the US?

No. Now Patient does not provide progesterone coupons or FREE progesterone samples.

Do you accept commercial, Medicare or Medicaid coverage for progesterone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much progesterone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using progesterone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much progesterone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of progesterone and manufacturer

Progesterone is available in the US under various brand names, including Prometrium, Crinone, and Endometrin. It is manufactured by multiple pharmaceutical companies.

UK brand name of progesterone and manufacturer

Progesterone is available in the UK under various brand names, including Utrogestan and Cyclogest. It is manufactured by different pharmaceutical companies.

Is progesterone available in the UK on the NHS?

Yes, progesterone is available on the NHS in the UK.

Prescription requirement for progesterone

Progesterone is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of progesterone and mechanism of action

Progesterone is an endogenous steroid hormone. Progesterone production happens in the adrenal glands and also ovaries.  It plays a vital role in the female reproductive system. It is normally secreted by the corpus luteum in the ovary during the second half of the menstrual cycle (normal menstruation).  It is involved in the regulation of the menstrual cycle and is essential for maintaining pregnancy. Progesterone binds to progesterone receptors in the body, influencing various physiological processes.
Progesterone plays several important roles in the body:

  • Menstrual cycle: During the menstrual cycle, progesterone helps to regulate the lining of the uterus. It prepares the endometrium (the lining of the uterus) to receive a fertilized egg. If a fertilized egg does not attach to the endometrium, progesterone levels drop and menstrual bleeding occurs
  • Pregnancy: If a fertilized egg does attach to the endometrium (meaning pregnancy has occurred), progesterone helps maintain the endometrium to support the ongoing pregnancy. Progesterone is secreted by the placenta, during the later phase of pregnancy

As a medication, progesterone is used in several ways, including:

  • Hormone replacement therapy (HRT): For women who have passed menopause, it is often used as part of HRT, usually in combination with estrogen. The progesterone can help counteract the risk of uterine cancer that can come with taking estrogen alone
  • Infertility and pregnancy support: Progesterone can also be used in fertility treatments, to help prepare the endometrium for implantation of a fertilized egg, and to support early pregnancy
  • Birth control: Progesterone (or more often, a synthetic version called a progestin) is also a common component of many forms of hormonal birth control, including oral contraceptive birth control pills, intrauterine devices (IUDs), and implants. In this context, it works primarily by preventing ovulation and by making the endometrium less hospitable to a fertilized egg

Uses of progesterone

Progesterone is used for various purposes, including:

  • Menopausal symptoms and hormone replacement therapy (HRT): Progesterone is often used in combination with estrogen as part of HRT to manage symptoms of menopause, such as hot flashes and night sweats. Progesterone helps to counteract the effect of estrogen on the uterus, reducing the risk of endometrial hyperplasia and possibly endometrial cancer
  • Amenorrhea: This is a condition where menstrual periods stop or do not begin. Progesterone can be used to stimulate menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body
  • Abnormal uterine bleeding: Progesterone is often used to manage this condition, especially when it’s due to hormonal imbalance
  • Infertility treatments: Progesterone can be used as part of assisted reproductive technology procedures such as in-vitro fertilization (IVF). It can help prepare the lining of the uterus for embryo implantation
  • Prevention of premature birth: In certain cases where a woman has a history of delivering too early, progesterone can be used to help prevent another premature birth
  • Contraception: Progesterone, often in a synthetic form called a progestin, is a common ingredient in many forms of hormonal birth control, including pills, patches, injections, intrauterine devices (IUDs), and implants

Remember to always consult with a healthcare provider for personal medical advice. Progesterone may have side effects, interactions, and may not be suitable for everyone. It should always be used under the supervision of a healthcare provider

Forms of progesterone

  • Oral: Progesterone can be taken by mouth in the form of capsules, often used for hormone replacement therapy in menopausal women and sometimes in fertility treatments
  • Injectable: Progesterone can be injected directly into the muscle or under the skin. This form is often used in fertility treatments and to prevent preterm birth in certain high-risk pregnancies
  • Topical: Progesterone can be used topically as a cream or gel. Topical progesterone is often used for hormone replacement therapy, and the gel form can also be used in fertility treatments
  • Vaginal: Progesterone can be inserted into the vagina as a gel, tablet, or suppository. This form is often used in fertility treatments and to supplement progesterone in early pregnancy
  • Intrauterine device (IUD): Some IUDs release a form of progesterone (progestin) to prevent pregnancy
  • Implants and injections: Some forms of long-term birth control involve implants or injections that slowly release a form of progesterone (progestin)

Dosage of progesterone

The dosage of progesterone can vary widely depending on the reason it’s being used, the specific formulation, and individual patient factors. As a result, it’s crucial to follow the directions given by your healthcare provider or pharmacist. Below are some general dosing guidelines for different uses of progesterone:

  • Menopausal symptoms / hormone replacement therapy (HRT): For oral progesterone, the typical dose is 200 mg taken at bedtime for 12 to 14 consecutive days per 28-day cycle. Topical doses can vary but are often around 20 mg per day
  • Amenorrhea and abnormal uterine bleeding: For these conditions, the typical oral dose of progesterone is 400 mg per day for 10 days
  • Assisted reproductive technology (ART): For use in ART like in-vitro fertilization (IVF), progesterone is often given as an intramuscular injection at a dose of 50 to 100 mg per day, or as a vaginal gel, insert, or suppository at a dose of 90 to 100 mg per day
  • Prevention of premature birth: In women who have previously had a premature birth, a dose of 250 mg of progesterone is typically given as an intramuscular injection once a week, starting between 16 and 20 weeks of pregnancy and continuing until 37 weeks of pregnancy

Precautions and warnings for progesterone

  • Allergic reactions: Some people may have an allergic reaction to progesterone. If you have any signs of an allergic reaction such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, get emergency medical help immediately
  • Cardiovascular disorders: Progesterone can cause fluid retention, which can exacerbate conditions like heart failure, kidney disease, or high blood pressure. People with these conditions should use progesterone with caution
  • Liver disease: Progesterone should be used with caution in people with liver disease, as the liver is involved in metabolizing the drug
  • Breast cancer and Other Hormone-Sensitive Cancers: Because progesterone is a hormone, it can potentially stimulate the growth of certain hormone-sensitive cancers. People with a personal or family history of hormone-sensitive cancers (such as breast cancer or ovarian cancer) should discuss the risks and benefits with their doctor before using progesterone
  • Blood clots: Progesterone, especially when taken with estrogen, can increase the risk of blood clots. The risk is higher in women who smoke or who have a personal or family history of blood clots
  • Mental health disorders: Progesterone can cause mood changes and can potentially exacerbate mental health conditions like depression
  • Pregnancy and breastfeeding: While progesterone is often used during pregnancy to support the pregnancy or prevent premature birth, its use should always be guided by a healthcare provider. Breastfeeding while using progesterone should also be discussed with a healthcare provider, as small amounts can pass into breast milk

Side effects of progesterone

Common side effects may include:

  • Drowsiness or dizziness
  • Headache
  • Breast pain or breast tenderness
  • Mood changes or depression
  • Abdominal pain or cramping
  • Nausea, bloating or diarrhea
  • Joint or muscle pain

Serious side effects are less common, but they can occur. These can include:

  • Chest pain or discomfort
  • Difficulty breathing or shortness of breath
  • Pain in the arm, back, neck, or jaw
  • Unusual or sudden body or facial swelling
  • Severe headache or vomiting, dizziness or fainting, disturbances of vision or speech, or weakness or numbness in an arm or leg (possible signs of a stroke)
  • Severe abdominal pain, yellowing of the skin or eyes, dark urine (possible signs of a liver problem)
  • Unusual vaginal bleeding

Drug interactions

Potential drug interactions with progesterone include:

  • Rifampin and other antibiotics or antifungal medications: Some antibiotics and antifungal medications can make progesterone less effective, potentially leading to a return of symptoms or, in the case of contraceptive use, an increased risk of pregnancy
  • Certain seizure medications: Medications like phenytoin, carbamazepine, and phenobarbital can decrease the effectiveness of progesterone
  • St. John’s Wort: This herbal supplement can reduce the effectiveness of progesterone
  • Anticoagulants or blood thinners: Progesterone may increase the risk of blood clotting, which can be especially problematic if you are also taking a blood thinner like warfarin
  • Other hormonal medications: Progesterone can interact with other hormonal medications, including other forms of hormone therapy and hormonal contraceptives. This can affect the balance of hormones in your body and potentially increase the risk of side effects
  • Certain HIV medications: Some medications used to treat HIV can decrease the levels of progesterone in your body, potentially making it less effective.


  • Prometrium (Progesterone) Prescribing Information – Merck Sharp & Dohme Corp.
  • Utrogestan (Progesterone) Summary of Product Characteristics – electronic Medicines Compendium (eMC).
  • Progesterone – MedlinePlus.


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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