What is Amlodipine and what is it used for?

What is Amlodipine and what is it used for?

2 Feb 2023
Stefano Mirabello
Stefano Mirabello
Medical Writer

If you’ve been diagnosed with high blood pressure or hypertension, you’re not alone. In fact, according to the Centers for Disease Control and Prevention (CDC), one in three adults in the UK has high blood pressure. It is a common condition that can sometimes improve with lifestyle changes such as stopping smoking, getting to a healthy weight or increasing physical activity.

All these changes will certainly help but medicines can unquestionably lower your blood pressure significantly more than lifestyle changes on their own. There are many prescription drugs available to your doctor to prescribe these include ACE (angiotensin-converting enzyme) inhibitors, ARB (angiotensin receptor blockers) and CCB (calcium channel blockers). Let us take a look at Amlodipine a commonly prescribed drug from the calcium channel blocker class of drugs.

What is high blood pressure?

As the symptoms of high blood pressure are subtle they can often go unnoticed. You may not be aware of having high blood pressure until it is checked as part of your NHS Health Check, at a GP/Nurse appointment or possibly at a pharmacy.

When your blood pressure is taken you will be given two separate numbers for its measurement. You will be given the systolic pressure and the diastolic pressure. According to Blood Pressure UK: the systolic pressure (top number) measures the highest force of pressure your blood reaches when beating and forcing blood around the body. The diastolic pressure (bottom number) measures the lowest force of pressure your blood reaches as your heart relaxes between beats.

As a general guide the NHS consider:

  • High blood pressure to be 140/90mmHg or higher (or 150/90mmHg or higher if you’re over the age of 80)
  • At risk of developing high blood pressure between 120/80mmHg and 140/90mmHg
  • Ideal blood pressure to be between 90/60mmHg and 120/80mmHg


Treatment for high blood pressure

There are two main options for treating high blood pressure:

  • Changes to lifestyle would involve eating a healthy diet, reducing salt intake, increasing consumption of fruit and veg, increasing physical activity, aiming for a healthier weight, reducing or cutting out alcohol, limiting caffeine intake and stopping smoking
  • MedicationThe choice of medicine will depend on which option is best for you after a discussion with your healthcare professional. Your age, the condition being treated, how high your blood pressure is, other medical conditions you have and your ethnicity are factors that will be taken into consideration when medication is prescribed

About Amlodipine

Amlodipine is a prescription drug that can be used alone or in addition to other blood pressure-lowering drugs. In the long-term the aim of lower blood pressure is to help prevent heart attacks, strokes, heart failure, coronary artery disease and kidney problems.

Amlodipine can be used in adults and children six years or older to treat:

  • High blood pressure (hypertension)
  • Angina pectoris (chest pain caused by blockages in the arteries leading to the heart)
  • Vasospastic angina pectoris (or Prinzmetal’s angina)


Amlodipine can be called a few different names due to the different salts available: amlodipine besylate, amlodipine maleate or amlodipine mesilate. It is a generic drug but it is also commercially available under the brand name Istin in the UK and Norvasc in the US.

In simple terms, the drug works by relaxing blood vessels so blood can flow more easily. Calcium is an essential component to allow the movement of muscles. Calcium channel blockers like Amlodipine block calcium from entering muscle cells of the heart and blood vessels. This results in the heart beating with less pressure and helps the blood vessels relax.


Amlodipine is available as 2.5 mg, 5 mg and 10 mg tablets or oral suspension/oral solution by special order. It is usually taken once a day but always follow the instructions given by your healthcare professional. The usual starting dose of amlodipine is 5mg once a day. If there is a missed dose of more than 12 hours skip that dose and take the next dose at your regular time.

Ideally, your dose should be taken at the same time each day, with or without food. It must be remembered to avoid consuming grapefruit or grapefruit juice while you are taking amlodipine as the fruit can increase the level of amlodipine in the body, making you more likely to suffer from side effects.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light

Common side effects

Some possible side effects of Amlodipine include:

  • Fatigue
  • Weakness
  • Ankle swelling
  • Muscle cramps
  • Gastrointestinal problems – abdominal pain, nausea, dyspepsia, altered bowel habits, diarrhoea and constipation
  • Shortness of breath
  • Heart palpitations
  • Visual disturbance including double vision
  • Dizziness
  • Headache
  • Drowsiness
  • Flushing

Serious side effects of amlodipine are not typical and you should seek medical advice immediately including:

  • Chest pain that’s worse than usual
  • heart attack
  • low blood pressure (hypotension)
  • allergic reaction skin rash itchiness flushing

What should I discuss with my healthcare provider before I start taking amlodipine?

Adverse effects of drug interactions and supplements

Discuss with your doctor all the medications you currently including prescription, over-the-counter and supplements. Some common interactions occur with the following drugs:

  • Clarithromycin, ketoconazole and itraconazole – are drugs that block an enzyme CYP3A4 (CYP3A4 inhibitors)
  • Rifampicin – drugs that induce an enzyme CYP3A4 (CYP3A4 inducers)
  • Cyclosporine and tacrolimus – immunosuppressant drugs
  • Sildenafil, tadalafil, avanafil and vardenafil are used to treat erectile dysfunction
  • Simvastatin is used at high doses to treat high cholesterol
  • St John’s Wort (a herbal remedy)

Pregnancy and breastfeeding

You should inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Some clinical studies have shown that amlodipine passes into breast milk in small amounts. You may need to decide with your doctor whether to stop breastfeeding or stop taking this medication.

Health conditions

Liver disease or liver problems

The liver is the primary site for drug metabolism. With this in mind if your liver is not working optimally amlodipine may stay in your body longer than required. For that reason, it puts you at risk for more side effects. Your doctor may consider a lower dose of amlodipine if you have severe liver problems.

Heart problems or heart disease

Heart problems, such as the narrowing of your arteries, may increase your risk of health problems when taking amlodipine. There is potential for developing low blood pressure, worsening chest pain, or suffering a heart attack after commencing treatment with this drug or increasing your dosage.

It would be best if you inform your doctor and any other healthcare professional involved in your care about all medical conditions you may have including medications you take.

Other groups, amlodipine is a contraindication for:

  • Allergic to amlodipine or any of the excipients resulting in symptoms such as hives and trouble breathing.
  • Children younger than six years of age
  • Pregnant women or women who are breastfeeding
  • Those with significantly low blood pressure (hypotension)
  • Heart failure patients following a heart attack
  • Patients with heart valve problems (e.g. aortic stenosis)

Other calcium channel blockers

Amlodipine is one of many calcium channel blockers available to your doctor to prescribe. Other calcium channel blockers include nifedipine, felodipine, lercanidipine, diltiazem and verapamil. Some may be better suited for you than others. Always speak to our healthcare professional for advice on medication or call your doctor.

Get your medicines through Now Patient our team can work with your GP to get the medicines you need to be delivered directly to your door.


Take control of your health today.

Now Patient is the UK’s first regulated digital health service that uses predictive analytics and artificial intelligence to provide you with personalised care and resources that can help improve your health outcomes, FREE of charge.

Now patient Diabetes calculator
Join the thousands of happy customers already using Now Patient.

Prescriptions, healthcare resources & live video consultations all in one place for FREE

Medicine reminder app screen
Your Questions Answered
For your peace of mind, we can answer your health questions quickly
Now Patient is the UK's first regulated digital health service using predictive analytics and artificial intelligence to offer targeted healthcare services, including FREE resources that can help improve your health outcomes.
Can I register with my NHS Login credentials?
Now Patient is connected directly with the NHS. This means you can use your existing NHS login credentials to create an account. Simply login to the service using the NHS blue login button. With NHS login, you can immediately unlock all the features of Now Patient.