Tacrolimus Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Tacrolimus
    Generic for Prograf
    30 capsules $6.9 USD
    Save $50.10
  3. Tacrolimus
    Generic for Prograf
    30 capsules $7.5 USD
    Save $49.50
  4. Tacrolimus
    Generic for Prograf
    180 capsules $28.8 USD
    Save $313.20
  5. Tacrolimus
    Generic for Protopic
    30g tube of ointments $35.2 USD
    Save $147.47
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Do you need a prescription for tacrolimus?

Yes, tacrolimus is only available with a valid physician Rx.

How much is tacrolimus without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase tacrolimus, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for tacrolimus in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a tacrolimus savings card?

Yes. Save up to 90% on your tacrolimus with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a tacrolimus coupon provider in the US?

No. Now Patient does not provide tacrolimus coupons or FREE tacrolimus samples.

Do you accept commercial, Medicare or Medicaid coverage for tacrolimus in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much tacrolimus?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using tacrolimus. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much tacrolimus. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic tacrolimus?

US brand name of tacrolimus and manufacturer

Tacrolimus is FDA-approved in the US under the brand names Astagraf XL, Envarsus XR and Prograf. It is manufactured by various manufacturers.

UK brand name of tacrolimus and manufacturer

Tacrolimus is available in the UK under the brand name Prograf. It is manufactured by Astellas Pharma Ltd. Protopic is a topical formulation and it is also manufactured by Astellas Pharma Ltd.

Is tacrolimus available in the UK on the NHS?

Yes, tacrolimus is available in the UK on the NHS as a prescription medication.

Prescription requirement for tacrolimus

Tacrolimus is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of tacrolimus and mechanism of action

The active ingredient in tacrolimus is tacrolimus monohydrate. It belongs to a class of medications known as calcineurin inhibitors. Tacrolimus works by suppressing the immune system to prevent the body from rejecting transplanted organs or tissues.

Uses of tacrolimus

Tacrolimus is an is an immunosuppressive drug primarily used to prevent organ rejection in transplant patients who have had an organ transplant, namely a  kidney transplant, liver transplant, lung transplant, or heart transplant. Topical applications are used for the treatment of certain skin conditions, such as atopic dermatitis. Tacrolimus may be used in combination with azathioprine, steroids, basiliximab, or mycophenolate mofetil.

Forms of tacrolimus

Tacrolimus is available in various forms, including oral capsules, granules, oral solution, immediate-release, and extended-release tablets for oral administration. It is also available as a topical ointment for external use on the skin.

Dosage of tacrolimus

The dosage of tacrolimus will vary depending on the specific transplant type, patient factors, and response to therapy. It is important to follow the medication guide provided by your healthcare provider. The medication is usually taken twice daily, with or without food.

Precautions and warnings for tacrolimus

  • Tacrolimus can suppress the immune system, increasing the risk of infections and certain types of cancer. Regular monitoring and follow-up with your healthcare provider are important during treatment
  • Inform your healthcare provider about any other medications you are taking, as tacrolimus may interact with certain drugs
  • Avoid exposure to sunlight and UV radiation, as tacrolimus can increase sensitivity to sunlight. Use sunscreen protection and avoid tanning beds
  • Patients using tacrolimus ointment may develop skin cancer or lymphoma
  • It is not known if this medication passes into breast milk. Speak to your doctor if you are breastfeeding
  • Avoid grapefruit juice or grapefruit while taking tacrolimus
  • Do not stop or adjust the dosage of tacrolimus without consulting your healthcare provider

Side effects of tacrolimus

In clinical trials common side effects of tacrolimus may include:

  • Increased risk of infections
  • High blood pressure
  • Tremors or shaking
  • Tiredness
  • Seizures
  • Hypertension
  • Diabetes mellitus
  • Hyperkalemia (high potassium levels)
  • Renal toxicity (change in urination)

Get medical help right away if you have any serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, and severe skin reactions. Promptly report any adverse effects to a healthcare professional for medical advice.

Interactions with other drugs

Tacrolimus may interact with certain medications, including antifungals such as fluconazole, itraconazole and voriconazole, calcium channel blockers such as diltiazem, cimetidine, erythromycin, vaccines, and aluminum or magnesium antacids. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, salt substitutes, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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