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tacrolimus

View tacrolimus savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or tacrolimus Patient Assistance Program.

Programs are suitable for individuals who want to buy tacrolimus without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by various FDA-approved generic manufacturers.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

Learn more about tacrolimus

What dosages is tacrolimus available in?

What dosages is tacrolimus available in?

tacrolimus is available as 0.5 mg, 1 mg, and 5 mg oral capsule and 0.2 mg and 1 mg granules for oral suspension,

What is tacrolimus used for?

What is tacrolimus used for?

tacrolimus is a calcineurin inhibitor that is used for the prevention of organ transplant rejection, including:

  • Kidney transplant
  • Liver or heart transplant – generic tacrolimus capsule and brand tacrolimus only
  • Lung transplant – brand tacrolimus only
How does tacrolimus work?

How does tacrolimus work?

tacrolimus is a calcineurin inhibitor. It works as an immunosuppressant, which lowers the activity of your immune system. You need a weakened immune system after receiving an organ transplant so your body doesn’t reject the new organ.

How do I take tacrolimus?

How do I take tacrolimus?

Your provider will determine your dose of tacrolimus based on your weight, ethnicity, kidney or liver health, the type of transplant you received, and the other immunosuppressants you’re taking. It is typically taken by mouth twice daily.

Is it safe for me to take tacrolimus?

Is it safe for me to take tacrolimus?

tacrolimus is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to tacrolimus or HCO-60 (polyoxyl 60 hydrogenated
castor oil).

tacrolimus Common Side Effects

tacrolimus Common Side Effects

Common side effects of tacrolimus:

  • Tremor
  • High blood pressure
  • Changes in electrolyte levels
  • Infections
  • Higher creatinine levels
  • Headache
  • Diarrhea
  • Nause
  • Swelling of hands and feet
  • Constipation
  • Feeling weak
  • General pain
  • Trouble sleeping
  • Low red blood cell count
tacrolimus Serious Side Effects

tacrolimus Serious Side Effects

Serious side effects are rare with tacrolimus. Contact your healthcare provider immediately if you experience any of the following.

  • Abnormal heart rhythm (QT prolongation): chest pounding, trouble breathing, chest pain, feeling faint or lightheaded
  • Serious infections: fever, cough, chills, sore throat, runny or stuffy nose, body aches
  • Low blood cell counts: bleeding that’s difficult to stop, vomiting blood, blood in the urine or stool, “coffee-ground” stool
  • Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
  • Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
  • Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
  • Nerve problems: seizures, tremors, headache, dizziness, pins sensation
Effects of other drugs, drug classes and over-the-counter products on tacrolimus

Effects of other drugs, drug classes and over-the-counter products on tacrolimus

The following medications may interact with tacrolimus:

  • Mycophenolic Acid Products: Can increase MPA exposure after crossover from cyclosporine to tacrolimus; monitor for MPA-related
  • adverse reactions and adjust MMF or MPA dose as needed
  • Nelfinavir and Grapefruit Juice: Increased tacrolimus concentrations via CYP3A inhibition; avoid concomitant use
  • CYP3A Inhibitors: Increased tacrolimus concentrations; monitor concentrations and adjust tacrolimus dose as needed
  • CYP3A4 Inducers: Decreased tacrolimus concentrations; monitor concentrations and adjust tacrolimus dose as needed
  • Therapeutic drug monitoring and dose reduction for tacrolimus should be considered when tacrolimus is co-administered with cannabidiol
Who makes tacrolimus?

Who makes tacrolimus?

Various FDA-approved generic manufacturers

Is tacrolimus safe in pregnancy?

Is tacrolimus safe in pregnancy?

tacrolimus can cause fetal harm when administered to a pregnant woman. There is a pregnancy registry that monitors pregnancy outcomes in women exposed to tacrolimus during pregnancy. The Transplantation Pregnancy Registry International (TPRI) is a voluntary pregnancy exposure registry that monitors outcomes of pregnancy in female transplant recipients and those fathered by male transplant recipients exposed to immunosuppressants including tacrolimus. Healthcare providers are encouraged to advise their patients to register by contacting the Transplantation Pregnancy Registry International at 1-877-955-6877 or
Transplant pregnancy registry 

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What to do if you missed your tacrolimus dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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