PROGRAF
Used for Immunosuppressant
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Manufactured by Astellas Pharma US, Inc.
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PROGRAF Uses, Side Effects, Interactions, Warnings & Dosing
What is PROGRAF?
PROGRAF is the brand name for tacrolimus and is available as an oral capsule and oral suspension.
What dosages is PROGRAF available in?
PROGRAF is available as 0.5 mg, 1 mg, and 5 mg oral capsule and 0.2 mg and 1 mg granules for oral suspension,
What is PROGRAF used for?
PROGRAF is a calcineurin inhibitor that is used for the prevention of organ transplant rejection, including:
- Kidney transplant
- Liver or heart transplant – generic tacrolimus capsule and brand Prograf only
- Lung transplant – brand Prograf only
How does PROGRAF work?
PROGRAF is a calcineurin inhibitor. It works as an immunosuppressant, which lowers the activity of your immune system. You need a weakened immune system after receiving an organ transplant so your body doesn’t reject the new organ.
How do I take PROGRAF?
Your provider will determine your dose of PROGRAF based on your weight, ethnicity, kidney or liver health, the type of transplant you received, and the other immunosuppressants you’re taking. It is typically taken by mouth twice daily.
Is it safe for me to take PROGRAF?
PROGRAF is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to tacrolimus or HCO-60 (polyoxyl 60 hydrogenated
castor oil).
PROGRAF Common Side Effects
Common side effects of PROGRAF:
- Tremor
- High blood pressure
- Changes in electrolyte levels
- Infections
- Higher creatinine levels
- Headache
- Diarrhea
- Nause
- Swelling of hands and feet
- Constipation
- Feeling weak
- General pain
- Trouble sleeping
- Low red blood cell count
PROGRAF Serious Side Effects
Serious side effects are rare with PROGRAF. Contact your healthcare provider immediately if you experience any of the following.
- Abnormal heart rhythm (QT prolongation): chest pounding, trouble breathing, chest pain, feeling faint or lightheaded
- Serious infections: fever, cough, chills, sore throat, runny or stuffy nose, body aches
- Low blood cell counts: bleeding that’s difficult to stop, vomiting blood, blood in the urine or stool, “coffee-ground” stool
- Heart attack: chest pain, stomach discomfort, sweating, nausea, dizziness
- Stroke: sudden numbness or weakness in the arm, leg, or face, confusion, trouble seeing, headache, difficulty walking
- Sudden kidney injury: feeling sick or weak, dehydration, urinating less than usual, confusion, blood in urine, swelling in the legs, ankles, or feet
- Nerve problems: seizures, tremors, headache, dizziness, pins sensation
Effects of other drugs, drug classes and over-the-counter products on PROGRAF
The following medications may interact with PROGRAF:
- Mycophenolic Acid Products: Can increase MPA exposure after crossover from cyclosporine to PROGRAF; monitor for MPA-related
- adverse reactions and adjust MMF or MPA dose as needed
- Nelfinavir and Grapefruit Juice: Increased tacrolimus concentrations via CYP3A inhibition; avoid concomitant use
- CYP3A Inhibitors: Increased tacrolimus concentrations; monitor concentrations and adjust tacrolimus dose as needed
- CYP3A4 Inducers: Decreased tacrolimus concentrations; monitor concentrations and adjust tacrolimus dose as needed
- Therapeutic drug monitoring and dose reduction for PROGRAF should be considered when PROGRAF is co-administered with cannabidiol
Who makes PROGRAF?
Astellas Pharma US, Inc.
Is PROGRAF safe in pregnancy?
PROGRAF can cause fetal harm when administered to a pregnant woman. There is a pregnancy registry that monitors pregnancy outcomes in women exposed to PROGRAF during pregnancy. The Transplantation Pregnancy Registry International (TPRI) is a voluntary pregnancy exposure registry that monitors outcomes of pregnancy in female transplant recipients and those fathered by male transplant recipients exposed to immunosuppressants including PROGRAF. Healthcare providers are encouraged to advise their patients to register by contacting the Transplantation Pregnancy Registry International at 1-877-955-6877 or
Transplant pregnancy registry
What to do if you missed your PROGRAF dose
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What is Prograf used for?
What does Prograf do to your body?
Does Prograf affect your kidneys?
What foods should you avoid while taking Prograf?
What not to mix with tacrolimus?
What fruits should transplant patients avoid?
What is the disadvantage of tacrolimus?
How long after taking Prograf can you eat?
Can you drink alcohol while on Prograf?
Why can't you drink alcohol with tacrolimus?
Is Prograf bad for the kidneys?
What are the side effects of Prograf on skin?
What medications should be avoided after transplant?
What are the long term side effects of Prograf?
What is the major side effect of Prograf anti rejection medication?
What medications Cannot be taken with tacrolimus?
What is the disadvantage of tacrolimus?
What are the two major toxicities of immunosuppressants?
Why is Prograf hazardous?
Do side effects of Prograf go away?
What are the neurological side effects of tacrolimus?
What are the symptoms of too much tacrolimus?
Can tacrolimus make you gain weight?
What cancers does tacrolimus cause?
What is a major side effect of long term immunosuppressive therapy?
What is generic for Prograf?
What is the substitute for Prograf?
Is tacrolimus an expensive drug?
How much does Prograf cost in the US?
How much does tacrolimus cost without insurance?
Does tacrolimus cause weight gain?
What foods should you avoid while taking tacrolimus?
Is there a difference between brand and generic tacrolimus?
What can I use instead of tacrolimus?
What is the new drug for tacrolimus?
What are the side effects of Prograf for kidneys?
Is tacrolimus Prograf a steroid?
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