BMI and the link to coronavirus (COVID-19)

BMI and the link to coronavirus (COVID-19)

17 Apr 2020
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm

What is BMI?

BMI stands for Body Mass Index. This is calculated using a person’s height and weight. The formula is BMI = kg/m2. Kg is a person’s weight in kilograms, and m2 is their height in metres squared. Healthy normal weight is classed as a BMI of 18.5 to 24.9. Overweight is classed as over 25.0 and obese is classed as a BMI of over 40. BMI applies to most adults 18-65 years.

Obesity is a complex disease with many contributing factors. Access to healthy, affordable food and safe and convenient places for physical activity can all affect obesity. Racial and ethnicity disparities in obesity underline the need to address social inequalities of health such as poverty, education, and housing.

What is Covid-19?

In December 2019, a new coronavirus named Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection) started spreading and triggered a global Covid-19 pandemic. This Coronavirus causes an illness known as Covid-19, a respiratory disease that can affect your lungs, throat, and nose. The disease has spread at an unprecedented speed and magnitude to become the greatest healthcare concern of the twenty-first century.

BMI and Covid-19

Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2 in Covid-19 patients with a BMI of 40+. These patients are at higher risk of contracting Coronavirus disease 2019. A recent NHS audit has revealed that almost two-thirds of patients who fall seriously ill from Coronavirus are obese, and nearly 40% are under the age of 60.

Covid-19 patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension (high blood pressure), and cancer have an increased risk of severe illness and increased risk of death due to Covid-19 infection. However, obesity has emerged as a major risk factor for hospital admissions and death due to Covid-19.

Obesity-related conditions seem to worsen the outcomes of Covid-19. The Centers for Disease Control and Prevention (CDC) reported that people with heart disease and diabetes are at higher risk of COVID-19 complications.

Facts about Obesity and COVID-19

  • Data extracted included demographic, clinical, and clinical values linked with Public Health England’s database of positive SARS-CoV-2 test results and death certificates from the Office of National Statistics. Outcomes, as a proxy measure of severe Covid-19, were admission to the hospital, admission to an intensive care unit (ICU), and death due to COVID-19
  • Systematic reviews and meta-analyses overwhelmingly show that obesity is associated with a high risk for ICU admission and poorer outcomes for Covid-19. In the UK, a report flags that out of 10,465 patients critically ill with confirmed Covid-19, 73.7% were overweight or obese
  • People with excess weight, even without other comorbidities, are at substantially increased risk of admission to hospital and death due to Covid-19, especially for younger adults and black people
  • Excess weight is a modifiable risk factor, and investment in the treatment of overweight and obesity, and long-term preventive strategies could help reduce the severity of Covid-19 disease
  • The proportion of patients who required invasive mechanical ventilation increased with BMI categories, and it was the greatest in patients with a BMI above 35 kg/m 2
  • Among those with Covid-19, young obese patients (< 60 years old and BMI > 35 kg/m2) were reported to be 3.6 times more likely to be admitted to the critical care unit than those with BMI < 30 kg/m2
  • Males of Black and Asian ethnicity and type 2 diabetes have been found to be associated with an increased risk of adverse outcomes from severe SARS-CoV-2 infection. One factor that links these groups is the tendency to store fat in the abdominal region and also in tissues other than adipose tissue, such as the liver, heart, or skeletal muscle
  • Two things happen when obesity occurs: the amount of fat increases, but also you put fat in the wrong places. You put it in the liver and skeletal muscle. And that disturbs metabolism. The key disturbance is that you get very high insulin levels in the blood. If we look at genetic markers for metabolic disturbance they are much more closely related to bad outcomes than genetic markers for obesity itself
  • People with a higher BMI tend to eat a diet with very little fibre and antioxidants, which normally keep the immune system healthy
  • Recent evidence has shown that obesity weakens the immune system and, therefore, makes the host vulnerable to infectious diseases. If you mount a very slow immune response, then you end up with greater viral replication
  • Studies have shown that physical activity increases the number of certain immune cells that help to bolster immune activity. Weight-loss interventions might reduce Covid-19 disease severity
  • People with a higher BMI are also more likely to suffer from diabetes and heart disease – two chronic conditions that put you at greater risk

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