Buy Colofac Online
Book a quick face-to-face video consultation with a certified prescribing pharmacist, nurse, or doctor. If approved, your Colofac will be prescribed* and delivered straight to your door with free next-day delivery†. No hidden fees. No delays. Just expert care.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.
Other Related Treatments
MEDICAL INFORMATION
Colofac Key Facts
About Colofac
Colofac contains mebeverine hydrochloride, an antispasmodic, as the active ingredient. It is used for the treatment of irritable bowel syndrome (IBS). Common symptoms of IBS, include stomach and intestine pain, intense bloating, flatulence, diarrhoea, and constipation. Colofac relaxes stomach muscles, reducing stomach cramps, a common symptom of irritable bowel syndrome.
It is available with a prescription or over the counter under the brand name Colofac. NowPatient offers Colofac as a treatment for IBS only, following an online consultation with a prescribing clinician.
Key facts of Colofac
- For the treatment of irritable bowel syndrome
- Colofac can take up to 1 hour to start working
- Colofac has some side effects which may include a mild itchy skin rash
- It can be dangerous if you take Colofac with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
Who is Colofac not suitable for?
Colofac may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before taking Colofac if you:
- Are allergic to mebeverine or any of the inactive ingredients such as lactose, povidone, talc, magnesium stearate, sucrose, gelatin, acacia or carnauba wax
- Are over 40 years of age
- Have new IBS symptoms or your symptoms have gotten worse
- Have liver or kidney problems
- Have blood in your stools
- Are under 18 years of age
How and where to get Colofac?
You can buy Colofac safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for the treatment of IBS, you can discuss if Colofac is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Colofac for irritable bowel syndrome
Colofac is available as 135 mg tablets when used for IBS.
Information about how to take Colofac for irritable bowel syndrome
Swallow Colofac tablets whole with a glass of water. For best results, take Colofac around 20 minutes before a meal. Adults should take 1 tablet 3 times a day. Do not take more than 3 Colofac tablets in any 24-hour period.
If you miss a dose take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take it at the next scheduled time.
What happens if you take too much Colofac?
If you take more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have taken too much Colofac and you experience any of the following side effects.
What are the side effects of Colofac?
Side effects of Colofac include:
- Mild itchy skin rash
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Swelling of the face, neck, tongue, or throat
- Difficulty breathing (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about taking Colofac at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Colofac. In any event, you should let your prescribing clinician know if you are taking any herbal supplements.
Can Colofac taken for irritable bowel syndrome be taken long term?
Mebeverine is not recommended for long term use. You should only take mebeverine if you have a flare-up of IBS symptoms.
Is there a herbal Colofac?
No. Herbal Colofac does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Colofac?
Women can take Colofac for IBS. Pregnant women or those breastfeeding however, should speak to a doctor before taking Colofac tablets.
Should I avoid any particular food or drink when taking Colofac?
You can eat and drink normally when taking Colofac tablets.
What lifestyle changes can I make to help me with irritable bowel syndrome?
- Manage your stress levels
- Eat a balanced diet
- Avoid foods that make your IBS worse
Alternatives to Colofac
Alternatives for the treatment of IBS include treatments such as Fybogel mebeverine sachets, Colpermin capsules, or Buscopan.
Sources
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Colofac
What is Colofac?
Colofac is the brand name for mebeverine hydrochloride, an antispasmodic medication used to treat the symptoms of irritable bowel syndrome (IBS) and other conditions involving gut spasms. It is available as Colofac 135 mg tablets and Colofac MR 200 mg (modified-release) capsules. Colofac IBS (135 mg) is available over the counter from pharmacies for adults aged 18 and over with a confirmed diagnosis of IBS. Higher-dose and modified-release formulations require a prescription.
How does Colofac work?
Mebeverine works directly on the smooth muscle of the gut, reducing spasms and relaxing the intestinal wall. It has a direct musculotropic action, meaning it acts on the muscle cells themselves rather than through the nervous system. This makes it different from anticholinergic antispasmodics. Mebeverine helps relieve the cramping, pain, and bloating associated with IBS without affecting normal gut motility or causing the anticholinergic side effects (dry mouth, blurred vision) associated with some other antispasmodics.
Is Colofac available over the counter?
Yes, Colofac IBS 135 mg tablets are available over the counter from pharmacies for adults aged 18 and over who have been previously diagnosed with IBS by a doctor. The pharmacist will confirm your diagnosis before supply. Colofac MR 200 mg capsules require a prescription. Generic mebeverine is also available on NHS prescription and is usually less expensive than the branded product.
How do I take Colofac?
For Colofac 135 mg tablets: take one tablet three times daily, approximately 20 minutes before meals. Swallow whole with water. For Colofac MR 200 mg capsules: take one capsule twice daily, 20 minutes before the two main meals of the day. Do not chew or crush MR capsules. Taking Colofac before meals helps it work when the gut is most active. Continue treatment for as long as symptoms persist.
How long does Colofac take to work?
Some patients notice improvement within a few days of starting Colofac, but it may take 2–4 weeks of regular use for the full benefit. If there is no improvement after 2 weeks of consistent use, consult your doctor. For best results, take Colofac regularly before meals rather than only when symptoms occur. Dietary modifications alongside Colofac often improve outcomes.
What are the side effects of Colofac?
Colofac has an excellent safety profile and side effects are rare. Occasional side effects include allergic skin reactions (rash, urticaria), and very rarely angioedema. Unlike anticholinergic antispasmodics, mebeverine does not cause dry mouth, blurred vision, constipation, or urinary retention. It does not cause drowsiness and does not affect driving ability. This favourable side effect profile makes it one of the most commonly recommended antispasmodics for IBS.
Can I take Colofac during pregnancy?
There is limited clinical data on mebeverine in pregnancy. It is generally avoided during pregnancy unless the prescriber considers the benefit outweighs the risk. If you are pregnant or planning to become pregnant, discuss IBS management options with your doctor. Dietary and lifestyle changes are preferred first-line approaches for IBS during pregnancy.
Can I take Colofac with other IBS treatments?
Yes, Colofac can be used alongside other IBS treatments including fibre supplements (such as ispaghula husk), peppermint oil capsules, loperamide (for diarrhoea-predominant IBS), laxatives (for constipation-predominant IBS), and low-dose antidepressants prescribed for IBS pain. It can also be used alongside the low-FODMAP diet. Discuss a comprehensive management plan with your GP.
How can I get Colofac?
Colofac IBS 135 mg is available OTC from pharmacies with a previous IBS diagnosis. Colofac MR and generic mebeverine are available on NHS prescription from your GP or online services like NowPatient. NowPatient offers online consultations for IBS management.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
Report to
OUR CUSTOMERS VIEW
What Customers Love About Our Service
We want everyone to be happy and healthy, that’s what keeps us going. Read what some of them have to say about us.
Medicines Experts
Meet Our Medical Team
We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
Ketan Patel
Stefano Mirabello
Monica Khosla
DeLon Canterbury
Amish Patel
Ihtesham Sabri
Jamie Winn
Daniel Cheung
Aseel Hamoud Bedan
Navin Khosla
Rajive Patel
