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Manufactured by various FDA-approved generic manufacturers.

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glecaprevir/pibrentasvir Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is glecaprevir/pibrentasvir available in?

What dosages is glecaprevir/pibrentasvir available in?

glecaprevir/pibrentasvir is available as an oral tablets that contains 100 mg glecaprevir and 40 mg pibrentasvir and oral pellets that contains 50 mg glecaprevir and 20 mg pibrentasvir.

What is glecaprevir/pibrentasvir used for?

What is glecaprevir/pibrentasvir used for?

glecaprevir/pibrentasvir is an antiviral and is used for the following:

  • Chronic (long-term) hepatitis C genotype 1, 2, 3, 4, 5, or 6 infection in certain people age 3 years and older
  • Hepatitis C genotype 1 infection in people age 3 years and older who were previously treated with an NS5A inhibitor or an HCV protease inhibitor (not both)
How does glecaprevir/pibrentasvir work?

How does glecaprevir/pibrentasvir work?

glecaprevir/pibrentasvir contains two antiviral medications that work together to stop the hepatitis C virus (HCV) from making copies of itself in the body. The two medications are glecaprevir (a protease inhibitor) and pibrentasvir (an NS5A inhibitor). They work by attacking two different proteins in the virus. Using two medications that work in different ways can prevent HCV resistance, which is when the virus develops a defense against antivirals. As a result, the medications no longer work to fight the virus.

How do I take glecaprevir/pibrentasvir?

How do I take glecaprevir/pibrentasvir?

glecaprevir/pibrentasvir is dosed as follows:

  • Adults, children age 12 years or older, and children who weigh at least 99 pounds: The recommended dose is 3 tablets by mouth once a day with food. The total daily dose is 300 mg of glecaprevir and 120 mg of pibrentasvir
  • Children age 3 to 12 years old: The dose is based on your child’s body weight. The provider will determine the right dose for your child. In general, the recommended dose ranges from 3 to 5 packets of oral pellets by mouth once a day with food
  • The treatment duration ranges from 8 to 16 weeks, depending on your previous HCV treatment regimens and your liver health
Is it safe for me to take glecaprevir/pibrentasvir?

Is it safe for me to take glecaprevir/pibrentasvir?

glecaprevir/pibrentasvir is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Patients with moderate or severe hepatic impairment (Child-Pugh B or C) or those with any history of prior hepatic decompensation
  • Coadministration with atazanavir or rifampin
glecaprevir/pibrentasvir Common Side Effects

glecaprevir/pibrentasvir Common Side Effects

Common side effects of glecaprevir/pibrentasvir:

  • Headache
  • Fatigue or tiredness
  • Nausea
glecaprevir/pibrentasvir Serious Side Effects

glecaprevir/pibrentasvir Serious Side Effects

Serious side effects are rare with glecaprevir/pibrentasvir. Contact your healthcare provider immediately if you experience any of the following.

  • Liver failure caused by hepatitis B virus reactivation: nausea, stomach pain, yellowing of your skin or whites of your eyes
Effects of other drugs, drug classes and over-the-counter products on glecaprevir/pibrentasvir

Effects of other drugs, drug classes and over-the-counter products on glecaprevir/pibrentasvir

The following medications may interact with glecaprevir/pibrentasvir:

  • Carbamazepine, efavirenz, and St. John’s wort may decrease concentrations of glecaprevir and pibrentasvir. Coadministration of carbamazepine efavirenz containing regimens, and St. John’s wort with glecaprevir/pibrentasvir is not
  • recommended
  • Clearance of HCV infection with direct-acting antivirals may lead to changes in hepatic function, which may impact safe and effective use of  concomitant medications. Frequent monitoring of relevant laboratory parameters (INR or blood glucose) and dose adjustments of certain concomitant medications may be necessary
  • Medication- Assisted Treatment (MAT) for Opioid Use Disorder
  • Consult the full prescribing information prior to and during treatment for potential drug interactions
Who makes glecaprevir/pibrentasvir?

Who makes glecaprevir/pibrentasvir?

Various FDA-approved generic manufacturers

Is glecaprevir/pibrentasvir safe in pregnancy?

Is glecaprevir/pibrentasvir safe in pregnancy?

No adequate human data are available to establish whether or not glecaprevir/pibrentasvir poses a risk to pregnancy outcomes. glecaprevir/pibrentasvir should be administered during pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your glecaprevir/pibrentasvir dose

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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