doravirine/lamivudine/tenofovir
Used for HIV
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Manufactured by various FDA-approved generic manufacturers.
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doravirine/lamivudine/tenofovir Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is doravirine/lamivudine/tenofovir available in?
doravirine/lamivudine/tenofovir is available as an oral tablet that contains 100 mg of doravirine, 300 mg of lamivudine, and 300 mg of
tenofovir disoproxil fumarate.
What is doravirine/lamivudine/tenofovir used for?
doravirine/lamivudine/tenofovir is a HIV ARV combo and is used for the following:
- People who have never taken HIV ARVs
- People who are well controlled on an HIV ARV regimen, have a viral load of less than 50, and want to switch regimens
How does doravirine/lamivudine/tenofovir work?
doravirine/lamivudine/tenofovir is an HIV ARV combination medication. It contains three medications that prevent HIV from infecting your cells and making copies of itself. Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It stops reverse transcriptase, an important enzyme needed for the virus to make DNA (genetic material). Lamivudine and tenofovir are nucleoside reverse transcriptase inhibitors (NRTIs). They insert themselves into the virus’ DNA and stop the DNA-making process.
How do I take doravirine/lamivudine/tenofovir?
doravirine/lamivudine/tenofovir is typically taken as 1 tablet by mouth once a day with or without food. Each tablet contains 100 mg of doravirine, 300 mg of lamivudine, and 300 mg of tenofovir.
Is it safe for me to take doravirine/lamivudine/tenofovir?
doravirine/lamivudine/tenofovir is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. doravirine/lamivudine/tenofovir is contraindicated when co-administered with drugs that
are strong cytochrome P450 (CYP)3A enzyme inducers as significant decreases in doravirine plasma concentrations may occur, which may decrease the effectiveness of doravirine/lamivudine/tenofovir.
doravirine/lamivudine/tenofovir is contraindicated in patients with a previous
hypersensitivity reaction to lamivudine.
doravirine/lamivudine/tenofovir Common Side Effects
Common side effects of doravirine/lamivudine/tenofovir:
- Dizziness
- Nausea
- Abnormal dreams
doravirine/lamivudine/tenofovir Serious Side Effects
Serious side effects are rare with doravirine/lamivudine/tenofovir. Contact your healthcare provider immediately if you experience any of the following.
- Liver problems if you have hepatitis B and suddenly stop taking doravirine/lamivudine/tenofovir: fever, tiredness, nausea, vomiting, stomach pain, dark urine, yellowing of your skin or eyes
- Kidney problems: swelling in your legs and feet, difficulty urinating, confusion, bone or muscle pain, pain in the arms or legs
Effects of other drugs, drug classes and over-the-counter products on doravirine/lamivudine/tenofovir
The following medications may interact with doravirine/lamivudine/tenofovir:
- Because doravirine/lamivudine/tenofovir is a complete regimen, co-administration with other antiretroviral medications for treatment of HIV-1 infection is not recommended
- Consult the full prescribing information prior to and during treatment for important potential drug-drug interactions
Who makes doravirine/lamivudine/tenofovir?
Various FDA-approved generic manufacturers
Is doravirine/lamivudine/tenofovir safe in pregnancy?
It is not known if doravirine/lamivudine/tenofovir can harm your unborn baby.
doravirine/lamivudine/tenofovir should only be used during pregnancy if the benefit to you is worth the possible risk to your baby. There is a pregnancy exposure registry that monitors pregnancy outcomes in individuals exposed to doravirine/lamivudine/tenofovir during pregnancy. Healthcare providers are encouraged to register patients by calling the Antiretroviral Pregnancy Registry (APR) at 1-800-258-4263.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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