DesmopressinPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Desmopressin Acetate
    Generic for DDAVP
    30 tablets $9 USD
    Save $80.70
  3. Desmopressin Acetate
    Generic for DDAVP
    30 tablets $9.3 USD
    Save $80.40
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Do you need a prescription for desmopressin?

Yes, desmopressin is only available with a valid physician Rx.

How much is desmopressin without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase desmopressin, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for desmopressin in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a desmopressin savings card?

Yes. Save up to 90% on your desmopressin with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a desmopressin coupon provider in the US?

No. Now Patient does not provide desmopressin coupons or FREE desmopressin samples.

Do you accept commercial, Medicare or Medicaid coverage for desmopressin in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much desmopressin?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using desmopressin. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much desmopressin. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic desmopressin?

Generic desmopressin refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of desmopressin

Desmopressin is approved by the U.S. Food and Drug Administration (FDA) for various indications, including the treatment of diabetes insipidus and nocturnal enuresis.

Active ingredient of desmopressin

The active ingredient of desmopressin is desmopressin acetate.

US brand name of desmopressin and manufacturer

Desmopressin is available in the US under various brand names, including DDAVP and Stimate. The manufacturers may vary depending on the brand names.

UK brand name of desmopressin and manufacturer

In the UK, desmopressin is available under various brand names, including Octim, DDAVP®; DesmoMelt; Desmospray; Desmotabs; Noqdirna. The manufacturer may vary depending on the brand name.

Prescription requirement for desmopressin

A prescription (Rx) is required for desmopressin in both the US and the UK.

Availability of desmopressin in the UK with NHS prescription

Desmopressin is available in the UK with an NHS prescription.

Conditions treated by desmopressin

Desmopressin is a medication primarily used for the treatment of certain conditions related to water balance in the body. It is a synthetic version of the hormone vasopressin, which is responsible for regulating the body’s water levels.
One of the main uses of desmopressin is to treat diabetes insipidus, a condition characterized by excessive thirst and urination. Desmopressin helps to reduce the frequent urination and excessive thirst associated with this condition by increasing the reabsorption of water in the kidneys.
Additionally, desmopressin is also used in the treatment of bedwetting (nocturnal enuresis) in children and adults. It helps to reduce the production of urine during sleep, allowing individuals to have a dry night.
Furthermore, desmopressin can be prescribed to manage bleeding disorders, such as hemophilia A and von Willebrand disease. It works by increasing the levels of clotting factor VIII and von Willebrand factor, which are necessary for proper blood clotting.

How does desmopressin work?

Desmopressin works by mimicking the action of vasopressin, which is a hormone produced naturally in the pituitary gland. Vasopressin plays a crucial role in regulating water reabsorption in the kidneys and controlling the concentration of urine.
When desmopressin is administered, it binds to specific receptors in the kidneys called vasopressin V2 receptors. This binding triggers a series of intracellular events that lead to the insertion of water channels, known as aquaporin-2 channels, into the cells of the renal collecting ducts. These channels allow water to be reabsorbed from the urine back into the bloodstream, resulting in a decrease in urine volume and an increase in urine concentration.
By increasing water reabsorption, desmopressin helps to reduce excessive urine production and control the symptoms of conditions such as diabetes insipidus, bedwetting (nocturnal enuresis), and excessive thirst associated with certain medical conditions.

Forms of desmopressin available

Desmopressin is available in various forms, including nasal sprays, tablets, and injectable formulations.

Dosage of desmopressin

The dosage of desmopressin may vary depending on the specific indication and the form of the medication. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for desmopressin use

Desmopressin should be taken or administered as directed by the healthcare provider. The specific instructions may include the timing of administration, dosage adjustments, and any necessary precautions.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Store desmopressin tablets at room temperature away from moisture, light, and heat.

Warnings and precautions for desmopressin

  • Individuals who have had a previous hypersensitivity or allergic reaction to desmopressin or any of its components should avoid using the medication. Signs of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing
  • Desmopressin works by increasing water reabsorption in the kidneys, which can potentially lead to dilutional hyponatremia, a condition characterized by low sodium levels in the blood. Therefore, desmopressin should be used with caution, or not at all, in patients with pre-existing hyponatremia or conditions that increase the risk of developing hyponatremia (e.g., heart failure, kidney disease)
  • Desmopressin can cause high blood pressure, especially in individuals with poorly controlled hypertension. Therefore, it should be used with caution or avoided in patients with uncontrolled high blood pressure
  • Desmopressin is primarily eliminated by the kidneys, so individuals with severe renal impairment may have a decreased ability to clear the medication from their system. This can increase the risk of side effects and potential toxicity. Dosage adjustments may be necessary for patients with renal impairment
  • Desmopressin is commonly used to treat bleeding disorders such as von Willebrand disease. However, it should be avoided in patients with type 2B von Willebrand disease, as it can potentially worsen bleeding symptoms in this specific subtype
  • Desmopressin should be used with caution in patients at risk of fluid overload, such as those with heart failure or certain kidney disorders. Excessive fluid retention can lead to complications such as edema and exacerbation of underlying conditions
  • It is important to follow the healthcare provider’s instructions regarding fluid intake and restrictions while using desmopressin

Drug interactions with desmopressin

Here are some drug interactions that have been reported with desmopressin:

  • Drugs like amitriptyline and imipramine, which belong to the TCA class, may increase the risk of water retention and hyponatremia (low sodium levels) when used in combination with desmopressin. Close monitoring by your doctor is necessary if you require both medications
  • Certain SSRIs (Selective Serotonin Reuptake Inhibitors) including fluoxetine and sertraline, may increase the risk of hyponatremia when used concomitantly with desmopressin. Hyponatremia is a condition characterized by low levels of sodium in the blood and can be potentially dangerous. Your doctor may need to adjust your medications or monitor your sodium levels closely if you are taking both desmopressin and an SSRI
  • Taking desmopressin in combination with other antidiuretic hormone (ADH) agonists medications such as carbamazepine or chlorpropamide, may increase the risk of water overload and hyponatremia. Your doctor will need to monitor your fluid balance and sodium levels closely if you are taking these medications together
  • Lithium is a medication commonly used to treat bipolar disorder. It can increase the antidiuretic effect of desmopressin, leading to the risk of water retention and hyponatremia. Close monitoring by your doctor is necessary if you are taking both medications

These are just a few examples of drug interactions that can occur with desmopressin. It is important to inform your healthcare professional about all the medications you are taking, including over-the-counter drugs, supplements, and herbal products, to ensure the safe use of desmopressin. They can assess the potential risks and benefits and make any necessary dosage adjustments or recommendations.

Use of desmopressin if pregnant or planning pregnancy

The use of desmopressin during pregnancy should be discussed with a healthcare provider. The potential benefits and risks should be evaluated on an individual basis.

Possible side effects of desmopressin

Common adverse effects of desmopressin may include headache, nausea, abdominal pain, and nasal congestion. Serious side effects are rare but can occur. Promptly report any concerning symptoms to a healthcare provider.

Similar drugs to desmopressin

Other medications, such as vasopressin analogues and antidiuretic hormone analogues, may be used as alternatives to desmopressin for the treatment of diabetes insipidus and related conditions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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