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conjugated estrogens/medroxyprogesterone acetate

conjugated estrogens/medroxyprogesterone acetate

Used for Menopause

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Manufactured by various FDA-approved generic manufacturers.

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conjugated estrogens/medroxyprogesterone acetate Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is conjugated estrogens/medroxyprogesterone acetate available in?

What dosages is conjugated estrogens/medroxyprogesterone acetate available in?

conjugated estrogens/medroxyprogesterone acetate is available as an oral tablet that contains 0.3 mg CE plus 1.5 mg MPA, 0.45 mg CE plus 1.5 mg MPA, 0.625 mg CE plus 2.5 mg MPA, or 0.625 mg CE plus 5 mg MPA.

What is conjugated estrogens/medroxyprogesterone acetate used for?

What is conjugated estrogens/medroxyprogesterone acetate used for?

conjugated estrogens/medroxyprogesterone acetate is an estrogen replacement / progestin and is used for the following:

  • Hot flashes, night sweats, and flushes caused by menopause
  • Vaginal dryness and burning caused by menopause
  • Prevention of postmenopausal osteoporosis (not a first-choice)
How does conjugated estrogens/medroxyprogesterone acetate work?

How does conjugated estrogens/medroxyprogesterone acetate work?

conjugated estrogens/medroxyprogesterone acetate is a combination of two medications. Conjugated estrogens is a mixture of estrogens that replaces the estrogen your body loses during menopause. It relieves hot flashes, relieves vaginal dryness, and strengthens bones. Medroxyprogesterone is a progestin that protects the uterus from damage and helps prevent uterine cancer.

How do I take conjugated estrogens/medroxyprogesterone acetate?

How do I take conjugated estrogens/medroxyprogesterone acetate?

conjugated estrogens/medroxyprogesterone acetate: Take 1 tablet by mouth once daily. Since there are many strengths of conjugated estrogens and medroxyprogesterone available, ask your provider which combination strength you should be taking.

Is it safe for me to take conjugated estrogens/medroxyprogesterone acetate?

Is it safe for me to take conjugated estrogens/medroxyprogesterone acetate?

conjugated estrogens/medroxyprogesterone acetate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if any of the following apply:

  • Undiagnosed abnormal genital bleeding
  • Known, suspected, or history of breast cancer
  • Known or suspected estrogen-dependent neoplasia
  • Active DVT, PE, or a history of these conditions
  • Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
  • Known anaphylactic reaction oar ngioedema to conjugated estrogens/medroxyprogesterone acetate/PREMPHASE
  • Known liver dysfunction or disease
  • Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders.
  • Known or suspected pregnancy
conjugated estrogens/medroxyprogesterone acetate Common Side Effects

conjugated estrogens/medroxyprogesterone acetate Common Side Effects

Common side effects of conjugated estrogens/medroxyprogesterone acetate:

  • Breast pain
  • Headaches
  • Stomach pain
  • Menstrual cramps
  • Gas
  • Nausea
  • Depression
  • More vaginal discharge than usual
conjugated estrogens/medroxyprogesterone acetate Serious Side Effects

conjugated estrogens/medroxyprogesterone acetate Serious Side Effects

Serious side effects are rare with conjugated estrogens/medroxyprogesterone acetate. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reactions
  • Heart attack: chest pain or tightness, pain that radiates up to your shoulder, arm, neck, or jaw
  • Stroke: sudden trouble talking, trouble walking, or numbness on one side of your body or face
  • Shortness of breath
  • Sudden, severe headaches
  • Breast lumps or pain
  • Unusual or heavy vaginal bleeding
Effects of other drugs, drug classes and over-the-counter products on conjugated estrogens/medroxyprogesterone acetate

Effects of other drugs, drug classes and over-the-counter products on conjugated estrogens/medroxyprogesterone acetate

The following medications may interact with conjugated estrogens/medroxyprogesterone acetate:

  • Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism
  • Aminoglutethimide administered concomitantly with MPA may significantly depress the bioavailability of medroxyprogesterone acetate
Who makes conjugated estrogens/medroxyprogesterone acetate?

Who makes conjugated estrogens/medroxyprogesterone acetate?

Various FDA-approved generic manufacturers

Is conjugated estrogens/medroxyprogesterone acetate safe in pregnancy?

Is conjugated estrogens/medroxyprogesterone acetate safe in pregnancy?

conjugated estrogens/medroxyprogesterone acetate and PREMPHASE should not be used during pregnancy

What is the brand name for conjugated estrogens/medroxyprogesterone acetate?

What is the brand name for conjugated estrogens/medroxyprogesterone acetate?

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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