Buy Sayana Press Online
Book a quick face-to-face video consultation with a certified prescribing pharmacist, nurse, or doctor. If approved, your Sayana Press will be prescribed* and delivered straight to your door with free next-day delivery†. No hidden fees. No delays. Just expert care.
* Includes Free Private Prescription & Consultation.
† Applies to UK only.
Other Related Treatments
MEDICAL INFORMATION
Sayana Press Key Facts
Other Related Names or Treatments
Depo-Provera, Sayana Press or Noristerat
About Sayana Press
Sayana Press is a contraceptive injection containing the hormone progestogen as the active ingredient. It is used for long-term female contraception. The subcutaneous injection prevents ovulation, thickens the mucus in the cervix, and thins the lining of the womb, providing contraception for a minimum of 13 weeks.
NowPatient offers Sayana Press as a contraceptive, following an online consultation with a prescribing clinician.
Key facts of Sayana Press
- For long-term contraception
- Sayana Press has some common side effects which include weight gain
- It can be dangerous if you use Sayana Press with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
- Sayana Press does not protect against sexually transmitted infections(STIs)
Who is Sayana Press not suitable for?
Sayana Press may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before using Sayana Press if you:
- Are allergic to medroxyprogesterone acetate
- Are pregnant
- Have unexplained vaginal bleeding
- Have liver disease
- Have breast cancer
- Have deep vein thrombosis or an embolism
- Have problems with your circulation
- Have a family history of osteoporosis
How and where to get Sayana Press?
You can buy Sayana Press safely and securely from NowPatient. You can start a consultation today for free and if you qualify for treatment, you only pay for the cost of the medication. Delivery is made to your home or office from our registered pharmacy.
Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for a contraceptive, you can discuss if Sayana Press is a suitable treatment option for you.
At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.
Dosage and strength for Sayana Press for contraception
Sayana Press is available as a 104 mg/0.65 ml subcutaneous suspension for injection.
Information about how to use Sayana Press for contraception
Administration of Sayana Press is normally carried out by a healthcare professional, however you may self inject if able to do so. When using Sayana Press, make sure the injection is at room temperature. Tear open the foil pouch containing the injection. Hold the injector and firmly shake it for at least 30 seconds to mix the medicine. When injecting, squeeze the injector with a slow even pressure over 5-7 seconds.
Inject Sayana Press under the skin into the front upper thigh or abdomen. Your first injection should only be given during the first 5 days of your menstrual cycle. Your next injection will be given after 12 to 13 weeks.
Read the patient information leaflet provided with your medication or speak to your healthcare provider for further medical advice.
What happens if you use too much Sayana Press?
If you use more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have used too much Sayan Press and you experience any of the following side effects:
What are the side effects of Sayana Press?
Possible side effects include:
- Weight gain
- Headaches, dizziness
- Mood swings, depression, difficulty sleeping
- Breast tenderness
- Irregular bleeding, amenorrhea (very light or no period), period pain
- Loss of bone mineral density
- Abdominal pain
- Acne
- Tiredness
- Injection site reactions
Serious side effects include:
- Seizures
- Abnormal liver function such as yellowing of the skin or eyes
- Breast cancer
If you experience any serious side effects, you should contact NHS 111.
If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.
- Your lips, mouth, throat or tongue suddenly become swollen
- You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
- Your throat feels tight or you’re struggling to swallow
- Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
- You suddenly become very confused, drowsy or dizzy
- Someone faints and cannot be woken up
Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient
Information about using Sayana Press at the same time as other medications or herbal supplements
There is not enough evidence to suggest there are any drug interactions between herbal supplements and Sayana Press. In any event, you should let your prescribing clinician know if you are taking any herbal supplements.
Can Sayana Press used for contraception be used long term?
Sayana Press should not be used for more than 2 years. Long term use can lead to a decrease in bone mineral density.
Is there a herbal Sayana Press?
No. Herbal Sayana Press does not exist. If you have been marketed such a formulation, it may be fake.
Can women use Sayana Press?
Women can use Sayana Press for contraceptive purposes. However, do not use Sayana Press if you are pregnant. If you are breast-feeding, you should not use Sayana Press any sooner than 6 weeks after childbirth, as Sayana Press may pass into breast milk.
Should I avoid any particular food or drink when using Sayana Press?
You can eat and drink normally when using Sayana Press.
Alternatives to Sayana Press
Alternative methods of contraception include:
- Implants
- Intrauterine devices (IUDs)
- Oral birth control pills (combined oral contraceptive and progestogen only pill)
- Vaginal rings
- Condoms
- Diaphragms
- Tubal ligation and vasectomy
- Emergency contraception
Sources
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Related Articles
FAQs
Answers to Popular Questions About Sayana Press
What is Sayana Press?
Sayana Press is a progestogen-only contraceptive injection containing medroxyprogesterone acetate 104 mg/0.65 ml in a pre-filled subcutaneous injection device. It provides contraceptive protection for 13 weeks (approximately 3 months). Unlike the older Depo-Provera injection (which is given intramuscularly by a healthcare professional), Sayana Press is designed for subcutaneous self-injection at home, making it more convenient. It is manufactured by Pfizer and is a prescription-only medicine.
How does Sayana Press work?
Sayana Press works primarily by suppressing ovulation through inhibition of the hypothalamic-pituitary-ovarian axis. Medroxyprogesterone acetate also thickens cervical mucus, making it difficult for sperm to reach the egg, and thins the endometrial lining, reducing the likelihood of implantation. These combined mechanisms make it a highly effective contraceptive method with over 99% effectiveness when injections are given on time.
Can I inject Sayana Press myself at home?
Yes, Sayana Press is specifically designed for self-administration at home. After initial training from a nurse or healthcare professional, you can inject it yourself subcutaneously (under the skin) into the front of the thigh or the abdomen. This removes the need for clinic appointments every 13 weeks. Your prescriber will arrange initial training and then can provide ongoing prescriptions. NowPatient can facilitate prescriptions for those trained in self-injection.
How do I inject Sayana Press?
Shake the pre-filled device firmly for 30 seconds before use. Clean the injection site (front of thigh or abdomen) with an alcohol swab. Pinch a large area of skin, insert the needle at a 45-degree angle, and slowly push the plunger down over 5–7 seconds until the device clicks and all the medication is delivered. Hold for 5 seconds, then withdraw. Press the skin firmly for a few seconds — do not rub. Dispose of the used device safely in a sharps bin.
When should I have my Sayana Press injection?
The first injection should be given within the first 5 days of your menstrual cycle for immediate protection. If started later, use condoms for the first 7 days. Subsequent injections are given every 13 weeks (91 days). You can have the injection up to 5 days early or up to 14 days late without needing additional contraception. If more than 14 days late, you may no longer be protected — use condoms and seek advice from your prescriber.
What are the side effects of Sayana Press?
Common side effects include irregular bleeding or spotting (especially in the first few months), weight gain (average 1.5–3 kg over 2 years), headache, mood changes, acne, breast tenderness, and reduced libido. Many women find that their periods become lighter and some stop altogether (amenorrhoea) after the first few injections. Injection site reactions (pain, induration, redness) may occur. A rare but important consideration is reduced bone mineral density with long-term use — discussed further below.
Does Sayana Press affect my bones?
Long-term use of medroxyprogesterone acetate (Sayana Press/Depo-Provera) is associated with a small reduction in bone mineral density (BMD). This is generally reversible after stopping the injection. FSRH guidance advises that the benefits usually outweigh the risks for most women, but careful assessment is needed for women under 18 (whose bones are still developing) and those with risk factors for osteoporosis. A review should occur every 2 years for women using it long-term. Alternative contraception may be preferable for those at high osteoporosis risk.
How long does it take for fertility to return after stopping Sayana Press?
Fertility may take longer to return after stopping Sayana Press compared to other contraceptive methods. On average, it takes about 5–6 months after the last injection was due for periods and ovulation to resume, but it can take up to 12–18 months for some women. This is important to consider when planning pregnancy. It does not cause permanent infertility. If planning a pregnancy, discuss timing with your prescriber.
How can I get Sayana Press?
Sayana Press can be prescribed by your GP, contraception clinic, or through online services like NowPatient. Initial training on self-injection is provided by a healthcare professional. Once trained, NowPatient can issue ongoing prescriptions with convenient home delivery of the pre-filled injection device.
Experienced a Side Effect?
Report to Yellow Card (UK) or MedWatch (US)
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