Sayana Press


Treatment options

Buy SAYANA PRESS safely, securely and easily in a few simple steps. Start a consultation today to check your eligibility with a prescribing clinician, at no cost to you.

Includes Free Private Prescription

This content is intended for UK audiences only

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Manufactured by Pfizer


Only £ per Pack

Dispensed in the UK
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Delivered securely by Royal Mail
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Updated on 26 Mar 2024

What to do if you missed your SAYANA PRESS dose

The MHRA's reporting program for suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.

Learn more about reporting side effects

Other known brand names

Depo-Provera, Sayana Press or Noristerat

About Sayana Press

Sayana Press is a contraceptive injection containing the hormone progestogen as the active ingredient. It is used for long-term female contraception. The subcutaneous injection prevents ovulation, thickens the mucus in the cervix, and thins the lining of the womb, providing contraception for a minimum of 13 weeks.

NowPatient offers Sayana Press as a contraceptive, following an online consultation with a prescribing clinician.

Key facts of Sayana Press

  • For long-term contraception
  • Sayana Press has some common side effects which include weight gain
  • It can be dangerous if you use Sayana Press with certain medications. If you’re not sure if it is safe, discuss this with the prescribing clinician
  • Sayana Press does not protect against sexually transmitted infections(STIs)

Who is Sayana Press not suitable for?

Sayana Press may not be suitable for some people. To make sure it’s safe for you, speak to the prescribing clinician before using Sayana Press if you:

  • Are allergic to medroxyprogesterone acetate
  • Are pregnant
  • Have unexplained vaginal bleeding
  • Have liver disease
  • Have breast cancer
  • Have deep vein thrombosis or an embolism
  • Have problems with your circulation
  • Have a family history of osteoporosis

How and where to get Sayana Press?

Sayana Press is available with a prescription only. It is not available over the counter at a pharmacy.

NowPatient does not allow customers to buy Sayana Press directly. Our service is certified, safe and effective, and we only ever treat conditions. If you book a consultation with a prescribing clinician for a contraceptive, you can discuss if Sayana Press is a suitable treatment option for you.

At the end of the consultation, the clinician will decide if a treatment plan is suitable for you. If it is, the clinician will issue you with a prescription which can then be ordered, paid for and delivered directly to your chosen address by NowPatient.

Dosage and strength for Sayana Press for contraception

Sayana Press is available as a 104 mg/0.65 ml subcutaneous suspension for injection.

Information about how to use Sayana Press for contraception

Administration of Sayana Press is normally carried out by a healthcare professional, however you may self inject if able to do so. When using Sayana Press, make sure the injection is at room temperature. Tear open the foil pouch containing the injection. Hold the injector and firmly shake it for at least 30 seconds to mix the medicine. When injecting, squeeze the injector with a slow even pressure over 5-7 seconds.

Inject Sayana Press under the skin into the front upper thigh or abdomen. Your first injection should only be given during the first 5 days of your menstrual cycle. Your next injection will be given after 12 to 13 weeks.

Read the patient information leaflet provided with your medication or speak to your healthcare provider for further medical advice.

What happens if you use too much Sayana Press?

If you use more than prescribed, then it can lead to some unpleasant side effects. You should talk to your doctor or reach out to one of our prescribing clinicians, if you have used too much Sayan Press and you experience any of the following side effects:

What are the side effects of Sayana Press?

Possible side effects include:

  • Weight gain
  • Headaches, dizziness
  • Mood swings, depression, difficulty sleeping
  • Breast tenderness
  • Irregular bleeding, amenorrhea (very light or no period), period pain
  • Loss of bone mineral density
  • Abdominal pain
  • Acne
  • Tiredness
  • Injection site reactions

Serious side effects include:

  • Seizures
  • Abnormal liver function such as yellowing of the skin or eyes
  • Breast cancer

If you experience any serious side effects, you should contact NHS 111.

If you experience a serious allergic reaction with the signs shown below you should contact emergency services on 999.

  • Your lips, mouth, throat or tongue suddenly become swollen
  • You’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
  • Your throat feels tight or you’re struggling to swallow
  • Your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
  • You suddenly become very confused, drowsy or dizzy
  • Someone faints and cannot be woken up

Always report adverse effects to the MHRA yellow card reporting system. You can read more about this here How and where do I report side effects of my medication? – NowPatient

Information about using Sayana Press at the same time as other medications or herbal supplements

There is not enough evidence to suggest there are any drug interactions between herbal supplements and Sayana Press. In any event, you should let your prescribing clinician know if you are taking any herbal supplements.

Can Sayana Press used for contraception be used long term?

Sayana Press should not be used for more than 2 years. Long term use can lead to a decrease in bone mineral density.

Is there a herbal Sayana Press?

No. Herbal Sayana Press does not exist. If you have been marketed such a formulation, it may be fake.

Can women use Sayana Press?

Women can use Sayana Press for contraceptive purposes. However, do not use Sayana Press if you are pregnant. If you are breast-feeding, you should not use Sayana Press any sooner than 6 weeks after childbirth, as Sayana Press may pass into breast milk.

Should I avoid any particular food or drink when using Sayana Press?

You can eat and drink normally when using Sayana Press.

Alternatives to Sayana Press

Alternative methods of contraception include:

  • Implants
  • Intrauterine devices (IUDs)
  • Oral birth control pills (combined oral contraceptive and progestogen only pill)
  • Vaginal rings
  • Condoms
  • Diaphragms
  • Tubal ligation and vasectomy
  • Emergency contraception


Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.


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