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Glycopyrrolate is available as a 1 mg and 2 mg oral tablet.

Glycopyrrolate is an anticholinergic that is used as an add-on treatment for stomach ulcers.

Glycopyrrolate belongs to a group of medications known as anticholinergics, which block a chemical in our body called acetylcholine. By blocking acetylcholine, Glycopyrrolate lowers the amount of acid in your stomach and helps to relieve symptoms of stomach ulcers.

The typical starting dose is 1 mg by mouth three times daily. The maximum daily dose is 8 mg. Your healthcare provider will work with you to adjust your dose based on your symptoms and side effects.

Glycopyrrolate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have:

• Glaucoma
• Obstructive uropathies, including prostatic hypertrophy
• Mechanical obstructive diseases of the gastrointestinal tract (e.g., pyloroduodenal stenosis, strictures)
• Gastrointestinal motility disorders (e.g., achalasia, paralytic ileus, intestinal atony)
• Bleeding gastrointestinal ulcer
• Active inflammatory or infectious colitis which can lead to toxic megacolon
• History of or current toxic megacolon
• Myasthenia gravis

Common side effects of Glycopyrrolate:

• Dry mouth
• Less sweating
• Difficulty urinating
• Constipation
• Nausea
• Vomiting
• Feeling bloated

Serious side effects are rare with Glycopyrrolate. Contact your healthcare provider immediately if you experience any of the following.

• Worsening glaucoma: dilated pupils with eye pain or redness
• Toxic megacolon: stomach pain, stomach swelling or bloating, fever, bloody diarrhea, fast heartbeat, confusion

The following medications may interact with Glycopyrrolate:

• There is potential for an additive interaction between Glycopyrrolate and concomitantly used anticholinergic drugs (e.g., tricyclic antidepressants, anti-epileptics, class I antiarrhythmics, anti­spasmodics, amantadine) resulting in increased anticholinergic adverse reactions
• Decreased gastrointestinal motility by Glycopyrrolate may impact absorption of other drugs leading to increased or decreased drug exposure. ROBINUL FORTE are not recommended in patients taking other drugs that are affected by altered gastrointestinal motility
• Oral Glycopyrrolate may worsen gastrointestinal mucosal injury reported with solid oral dosage forms of potassium chloride due to decreased gastric motility and increased transit time, leading to prolonged contact with the gastrointestinal mucosa. ROBINUL FORTE are not recommended in patients taking solid oral dosage forms of potassium chloride

Various FDA-approved generic manufacturers

It is not known if Glycopyrrolate will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Robinul-Forte