Fluocinonide Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Fluocinonide
    Generic for Lidex
    60mL solutions $21.39 USD
    Save $32.03
  3. Fluocinonide
    Generic for Lidex
    30g tube of creams $16.29 USD
    Save $37.13
  4. Fluocinonide
    Generic for Lidex
    60g tube of ointments $18.51 USD
    Save $34.91
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Do you need a prescription for fluocinonide?

Yes, fluocinonide is only available with a valid physician Rx.

How much is fluocinonide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase fluocinonide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for fluocinonide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a fluocinonide savings card?

Yes. Save up to 90% on your fluocinonide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a fluocinonide coupon provider in the US?

No. Now Patient does not provide fluocinonide coupons or FREE fluocinonide samples.

Do you accept commercial, Medicare or Medicaid coverage for fluocinonide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much fluocinonide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using fluocinonide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much fluocinonide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of fluocinonide and manufacturer

Fluocinonide is available in the US under various brand names, including Lidex, Vanos, and fluocinonide-E. It is manufactured by various pharmaceutical companies, such as Valeant Pharmaceuticals International, West-Ward Pharmaceuticals Corp., and Perrigo New York Inc.

UK brand name of fluocinonide and manufacturer

Fluocinonide is available in the UK under brands including Metosyn.

Prescription requirement for fluocinonide

Fluocinonide is a prescription medication, which means it requires a prescription (Rx) from a healthcare provider in the US and UK. It is important to consult with a healthcare professional who can evaluate your medical condition and determine if fluocinonide is appropriate for you.

FDA approval of fluocinonide

Fluocinonide has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of various skin conditions, including eczema, psoriasis, and dermatitis.

Is fluocinonide available in the UK on NHS?

Fluocinonide containing preparations are available in the UK with a National Health Service (NHS) prescription.

Mechanism of action

Fluocinonide is a highly potent synthetic corticosteroid that is used topically on the skin to alleviate symptoms associated with various skin conditions such as eczema, psoriasis, and allergic reactions. Its mechanism of action involves the following:

  • Anti-inflammatory action: Fluocinonide binds to the glucocorticoid receptors found within the cells. This complex then enters the nucleus and binds to DNA, influencing gene transcription. The resulting effect is decreased synthesis of pro-inflammatory proteins and increased synthesis of anti-inflammatory proteins. This leads to a reduction in the mediators of inflammation such as histamines, kinins, prostaglandins, and leukotrienes
  • Vasoconstrictive action: Fluocinonide also causes vasoconstriction (narrowing of the blood vessels), which reduces redness and heat caused by increased blood flow to the inflamed area
  • Immunosuppressive and antiproliferative action: By suppressing the immune response, fluocinonide can help reduce inflammation and allergic reactions. This immunosuppressive effect can also slow the rate of skin cell proliferation, which can be helpful in conditions such as psoriasis where skin cells are overproduced

Uses of fluocinonide

Fluocinonide is a potent topical corticosteroid used primarily to treat skin conditions that involve inflammation and itching. It’s used to alleviate symptoms associated with a variety of skin disorders. Here are some common uses:

  • Dermatitis: This includes atopic dermatitis (commonly known as eczema) and contact dermatitis, which are conditions characterized by itchy, inflamed skin
  • Psoriasis: This is a condition characterized by overactive skin cell growth that leads to thick, scaly patches on the skin. Fluocinonide can help reduce the inflammation, itching, and scale formation associated with psoriasis
  • Lichen Planus: This inflammatory condition causes a rash with flat-topped, shiny, and often itchy bumps. Fluocinonide can help reduce the inflammation and itching associated with lichen planus
  • Discoid lupus erythematosus (DLE): This is a chronic skin condition that involves sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas
  • Other skin conditions: Fluocinonide may also be used for other skin conditions that involve inflammation and itching as directed by a healthcare provider

Dosage of fluocinonide

Fluocinonide is a potent topical corticosteroid and its dosage will depend on the specific product (cream, gel, ointment, solution), the condition being treated, the severity of the symptoms, and the individual patient’s response.

Generally, if using a topical formulation, fluocinonide should be applied as a thin layer of and applied to the affected area 2-4 times daily. For some conditions, less frequent application may be recommended.

  • Always follow your healthcare provider’s instructions for using this medication. Use only the amount recommended, and do not use it more frequently or for a longer period of time than directed
  • Avoid using fluocinonide on large areas of the body or for extended periods of time unless directed by a healthcare provider. Prolonged, widespread use can lead to systemic absorption and associated side effects
  • Do not use this medication on the face, underarms, or groin area unless directed by a healthcare provider
  • If using on the scalp, part the hair and apply a small amount of the medicine
  • Do not use occlusive dressings (airtight coverings such as plastic wrap) unless directed by a healthcare provider, as these can increase absorption of the medication
  • For children and for individuals with impaired skin barrier function, the smallest amount of medication should be used for the shortest duration possible to minimize systemic absorption
  • If you forget to take a dose, take it as soon as you can. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time

Forms of fluocinonide

Fluocinonide is a topical corticosteroid that comes in several different forms for application to the skin, including:

  • Fluocinonide topical cream: This is a semi-solid emulsion of water and oil, and it’s suitable for many types of skin conditions. It’s commonly used for both wet (oozing, weepy) and dry, scaly lesions
  • Fluocinonide topical gel: The gel form is water-based rather than oil-based, which can make it feel less greasy. It’s often used for conditions affecting the scalp or other hairy areas because it’s easier to apply and wash out
  • Fluocinonide ointment: This form is oil-based, and it’s more occlusive, which means it helps lock in moisture. It’s often used for very dry, scaly lesions
  • Fluocinonide solution: This is a liquid form that is often used for the scalp or other hairy areas. Like the gel, it’s easy to apply and wash out
  • Fluocinonide lotion: This is a lighter, less greasy option that spreads easily and can be used on larger areas of skin

Each form of fluocinonide has its own advantages and is used for different types of skin conditions or areas of the body. Your healthcare provider will recommend the best form of fluocinonide for your specific needs. Always use the medication exactly as directed by your healthcare provider.

Precautions and warnings for fluocinonide

  • Fluocinonide should only be used externally and should not be ingested or applied to the eyes or mucous membranes
  • It is important to avoid using fluocinonide on open wounds, broken skin, or areas with active infection unless specifically directed by a healthcare professional
  • Prolonged use of fluocinonide may increase the risk of developing certain side effects, such as skin thinning, discoloration, or stretch marks. It is important to follow the treatment duration and guidelines provided by your healthcare provider
  • Inform your healthcare provider about any pre-existing medical conditions, such as diabetes or adrenal gland disorders, as fluocinonide may interact with these conditions
  • Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using fluocinonide. The use of topical corticosteroids during pregnancy or breastfeeding should be carefully evaluated and the potential risks and benefits should be considered

Side effects of fluocinonide

Common adverse effects of fluocinonide may include:

  • Burning, itching, or irritation at the application site
  • Dryness or cracking of the skin
  • Redness or rash
  • Changes in skin color

Serious side effects are less common but can occur, especially with long-term use, use over large areas of skin, or use under occlusive dressings (bandages or wraps that don’t allow air to circulate). These can include:

  • Thinning or softening of the skin
  • Stretch marks (striae)
  • Skin infection
  • Acne
  • Excessive hair growth (hypertrichosis)
  • Symptoms of adrenal gland suppression, such as tiredness, depression, and weight loss

An allergic reaction to fluocinonide is rare, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include itching, rash, severe dizziness, trouble breathing, or swelling of the face, lips, or tongue.

Warnings for fluocinonide

  • Children using topical fluocinonide may be at risk of delayed weight gain and slowed growth
  • Using topical fluocinonide on a child’s diaper area while using tight-fitting plastic pants or diapers can increase the risk of side effects
  • An allergic reaction to fluocinonide is rare, but seek immediate medical advice if it occurs. Symptoms of an allergic reaction include itching, rash, severe dizziness, trouble breathing, or swelling of the face, lips, or tongue

Interactions with other drugs

Fluocinonide is a topical corticosteroid and generally has few systemic drug interactions because it is not extensively absorbed into the bloodstream. However, interactions can still occur, particularly if you’re using a lot of fluocinonide, using it over large areas of skin, or using it for a long time.

  • Other topical medications: If you’re using other topical medications on the same area of skin, it’s important to discuss this with your healthcare provider, as the other medication may affect the absorption or effectiveness of fluocinonide
  • Corticosteroids: If you’re taking oral or injectable corticosteroids, there could potentially be an additive effect, leading to increased systemic corticosteroid side effects
  • Immunosuppressive drugs: These can also potentially have additive effects when used with topical corticosteroids, leading to a further suppression of the immune system
  • Certain cosmetics or soaps: Certain cosmetics, soaps, or skin care products can potentially cause skin irritation, especially if used in combination with potent topical corticosteroids like fluocinonide

Remember, this list may not be all-inclusive and other interactions can occur. Always tell your healthcare provider about all the medications, supplements, and skin products you’re using.


  • U.S. Food and Drug Administration (FDA)
  • National Health Service (NHS)
  • WebMD
  • Drugs.com


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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