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Xeloda is the brand name for capecitabine and is available as an oral tablet.

Xeloda is available as a 150 mg and 500 mg oral tablet.

Xeloda is an antimetabolite and is used for the following:
Colon cancer:

• After the tumor has been surgically removed
  Advanced or metastatic colon cancer

Rectal cancer:

• Together with radiation before or after surgery
• Advanced or metastatic rectal cancer
• Metastatic breast cancer
• Metastatic gastric, esophageal, or gastroesophageal junction (EGJ) cancer
• Pancreatic cancer, after the tumor has been surgically removed

Xeloda is an antimetabolite chemotherapy. Once it gets inside the body, Xeloda is converted into fluorouracil, which is the active form of this medication. It prevents cells from making the genetic material needed to grow and multiply. Because cancer cells tend to grow much faster than healthy cells, fluorouracil ends up affecting cancer cells more. As a result, cancer cells can’t grow and spread as well.

Xeloda dose is based on your body surface area (BSA), which takes into account your height and weight. The dose and duration of therapy also depends on what type of cancer you’re being treated for, and what other anticancer medications or treatments (e.g., radiation) you’re receiving.

• The typical dose ranges between 625 mg/m2 – 1250 mg/m2 by mouth twice a day
• If you’re receiving radiation, you’ll usually take Xeloda during radiation treatment, which can last several weeks
• If you’re not receiving radiation, Xeloda is commonly taken for 2 weeks out of every 3-week treatment cycle

Xeloda is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Xeloda:

• Hand-and-foot syndrome
• Diarrhea
• Nausea
• Fatigue or tiredness
• Stomach pain
• Vomiting
• Open mouth sores

Serious side effects are rare with Xeloda. Contact your healthcare provider immediately if you experience any of the following.

• Severe diarrhea or blood in your stool
• Severe skin reactions: rash, blisters, peeling skin, painful swelling
• Heart problems: heart attack, chest pain, abnormal heart rhythm

The following medications may interact with Xeloda:

• Anticoagulants: Monitor anticoagulant response (INR or prothrombin time) frequently in order to adjust the anticoagulant dose as needed
• Phenytoin: Monitor phenytoin levels in patients taking Xeloda concomitantly with phenytoin. The phenytoin dose may need to be reduced
• Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin
• CYP2C9 substrates: Care should be exercised when Xeloda is coadministered with CYP2C9 substrates
• Food reduced both the rate and extent of absorption of capecitabine

Genentech

Xeloda may cause harm to your unborn baby. Xeloda should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Capecitabine