Used for Cancer

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Manufactured by Genentech

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

XELODA Uses, Side Effects, Interactions, Warnings & Dosing

What is XELODA?

What is XELODA?

XELODA is the brand name for capecitabine and is available as an oral tablet.

What dosages is XELODA available in?

What dosages is XELODA available in?

XELODA is available as a 150 mg and 500 mg oral tablet.

What is XELODA used for?

What is XELODA used for?

XELODA is an antimetabolite and is used for the following:
Colon cancer:

  • After the tumor has been surgically removed
    Advanced or metastatic colon cancer

Rectal cancer:

  • Together with radiation before or after surgery
  • Advanced or metastatic rectal cancer
  • Metastatic breast cancer
  • Metastatic gastric, esophageal, or gastroesophageal junction (EGJ) cancer
  • Pancreatic cancer, after the tumor has been surgically removed
How does XELODA work?

How does XELODA work?

XELODA is an antimetabolite chemotherapy. Once it gets inside the body, XELODA is converted into fluorouracil, which is the active form of this medication. It prevents cells from making the genetic material needed to grow and multiply. Because cancer cells tend to grow much faster than healthy cells, fluorouracil ends up affecting cancer cells more. As a result, cancer cells can’t grow and spread as well.

How do I take XELODA?

How do I take XELODA?

XELODA dose is based on your body surface area (BSA), which takes into account your height and weight. The dose and duration of therapy also depends on what type of cancer you’re being treated for, and what other anticancer medications or treatments (e.g., radiation) you’re receiving.

  • The typical dose ranges between 625 mg/m2 – 1250 mg/m2 by mouth twice a day
  • If you’re receiving radiation, you’ll usually take XELODA during radiation treatment, which can last several weeks
  • If you’re not receiving radiation, XELODA is commonly taken for 2 weeks out of every 3-week treatment cycle
Is it safe for me to take XELODA?

Is it safe for me to take XELODA?

XELODA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

XELODA Common Side Effects

XELODA Common Side Effects

Common side effects of XELODA:

  • Hand-and-foot syndrome
  • Diarrhea
  • Nausea
  • Fatigue or tiredness
  • Stomach pain
  • Vomiting
  • Open mouth sores
XELODA Serious Side Effects

XELODA Serious Side Effects

Serious side effects are rare with XELODA. Contact your healthcare provider immediately if you experience any of the following.

  • Severe diarrhea or blood in your stool
  • Severe skin reactions: rash, blisters, peeling skin, painful swelling
  • Heart problems: heart attack, chest pain, abnormal heart rhythm
Effects of other drugs, drug classes and over-the-counter products on XELODA

Effects of other drugs, drug classes and over-the-counter products on XELODA

The following medications may interact with XELODA:

  • Anticoagulants: Monitor anticoagulant response (INR or prothrombin time) frequently in order to adjust the anticoagulant dose as needed
  • Phenytoin: Monitor phenytoin levels in patients taking XELODA concomitantly with phenytoin. The phenytoin dose may need to be reduced
  • Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorin
  • CYP2C9 substrates: Care should be exercised when XELODA is coadministered with CYP2C9 substrates
  • Food reduced both the rate and extent of absorption of capecitabine
Who makes XELODA?

Who makes XELODA?


Is XELODA safe in pregnancy?

Is XELODA safe in pregnancy?

XELODA may cause harm to your unborn baby. XELODA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


What to do if you missed your XELODA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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