Carbidopa-LevodopaPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Carbidopa-Levodopa
    Generic for Sinemet
    30 tablets $5.1 USD
    Save $9.30
  3. Carbidopa-Levodopa
    Generic for Sinemet
    30 tablets $4.8 USD
    Save $9.60
  4. Carbidopa-Levodopa ER
    Generic for Sinemet CR
    30 extended release tablets $6.6 USD
    Save $28.50
  5. Carbidopa-Levodopa ER
    Generic for Sinemet CR
    45 extended release tablets $9.3 USD
    Save $43.35
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Do you need a prescription for carbidopa-levodopa?

Yes, carbidopa-levodopa is only available with a valid physician Rx.

How much is carbidopa-levodopa without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase carbidopa-levodopa, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for carbidopa-levodopa in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a carbidopa-levodopa savings card?

Yes. Save up to 90% on your carbidopa-levodopa with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a carbidopa-levodopa coupon provider in the US?

No. Now Patient does not provide carbidopa-levodopa coupons or FREE carbidopa-levodopa samples.

Do you accept commercial, Medicare or Medicaid coverage for carbidopa-levodopa in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much carbidopa-levodopa?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using carbidopa-levodopa. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much carbidopa-levodopa. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic carbidopa-levodopa?

Generic carbidopa-levodopa refers to the non-brand-name version of the medication. It contains the same active ingredients as the brand-name drug but is typically less expensive.

FDA approval of carbidopa-levodopa

Carbidopa-levodopa is approved by the U.S. Food and Drug Administration (FDA) for the treatment of Parkinson’s disease and Parkinsonism.

Active ingredients of carbidopa-levodopa

The active ingredients of carbidopa-levodopa are carbidopa and levodopa.

US brand name of carbidopa-levodopa and manufacturer

Carbidopa-levodopa is available in the US under various brand names, including Duopa, Parcopa, Sinemet, Rytary, and generic versions. It is manufactured by different pharmaceutical companies.

UK brand name of carbidopa-levodopa and manufacturer

In the UK, carbidopa-levodopa is available under various brand names, including Madopar, Sinemet CR, and Stalevo (a combination of carbidopa/levodopa and entacapone). The manufacturer may vary depending on the brand name.

Prescription requirement for carbidopa-levodopa

A prescription (Rx) is required for carbidopa-levodopa in both the US and the UK.

Availability of carbidopa-levodopa in the UK with NHS prescription

Carbidopa-levodopa is available in the UK with an NHS prescription.

Conditions treated by carbidopa-levodopa

Carbidopa-levodopa is primarily used for the treatment of Parkinson’s disease, a neurodegenerative disorder that affects movement control. It can also be used for Parkinsonism, which refers to a group of neurological conditions that cause symptoms similar to Parkinson’s disease.

How does carbidopa-levodopa work?

Carbidopa-levodopa works by increasing the levels of dopamine in the brain. Levodopa is converted to dopamine in the brain, while carbidopa enhances the effects of levodopa by preventing its breakdown before it reaches the brain. The increased dopamine levels help to alleviate the symptoms of Parkinson’s disease.

Forms of carbidopa-levodopa available

Carbidopa-levodopa is available in various formulations including immediate release tablets, extended release tablets, disintegrating tablets, and capsules.

Dosage of carbidopa-levodopa

The dosage of carbidopa-levodopa may vary depending on the specific product, the severity of symptoms, and individual patient factors. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for carbidopa-levodopa use

Carbidopa-levodopa should be taken exactly as directed by the healthcare provider. The tablets or capsules are usually taken orally, with or without food. The dosage may be adjusted based on individual response and tolerability.

Warnings and precautions for carbidopa-levodopa

  • Carbidopa-levodopa may have certain risks and potential side effects. It is important to discuss these with a healthcare provider before starting the medication
  • Tell your doctor if you have liver disease, glaucoma, asthma, heart disease, kidney disease, mental health disorders, seizures, or sleep disorders
  • It is not known if this medication passes into breast milk. Speak to your doctor before breast-feeding
  • Avoid sudden discontinuation of carbidopa-levodopa, as it may lead to a worsening of symptoms. The dosage should be gradually reduced under the guidance of a healthcare provider

Use of carbidopa-levodopa if pregnant or planning pregnancy

The use of carbidopa-levodopa during pregnancy should be discussed with a healthcare provider. It is generally avoided unless the potential benefits outweigh the risks.

Possible side effects of carbidopa-levodopa

Common side effects of carbidopa-levodopa may include nausea, dizziness, lightheadedness, drowsiness, and dyskinesia (involuntary movements). Serious side effects include worsening of movements you can not control, twitching, blurred vision, abdominal pain, confusion, chest pain, unusual tiredness, and increased sexual urges. Contact your doctor for medical advice if you experience serious side effects.

Interactions with other drugs

Carbidopa-levodopa may interact with other medications, including drugs used to treat high blood pressure, and MAO inhibitors (isocarboxazid, linezolid, moclobemide, phenelzine, selegiline, and tranylcypromine. It is important to inform your healthcare provider about all the prescription drugs, over the counter medication, multivitamins, and supplements (especially iron supplements) you are taking, to avoid potential drug interactions and adverse effects.

Similar drugs to carbidopa-levodopa

Other medications used for the treatment of Parkinson’s disease include dopamine agonists such as pramipexole and ropinirole, as well as other combination products containing levodopa and carbidopa.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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