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Rytary is the brand name for carbidopa and levodopa extended-release oral capsules.

Rytary is available as an extended release carbidopa/levodopa capsules in strengths of 23.75 mg/95 mg, 36.25 mg/145 mg, 48.75 mg/195 mg, 61.25 mg/245 mg.

Rytary is a dopa decarboxylase inhibitor/dopamine replacement that is used to treat:

• Parkinson’s disease (PD)
• Parkinsonism (conditions that cause people to have signs and symptoms found in PD, including slowness, stiffness, shakiness, and imbalance)

Rytary is a combination of two medications: carbidopa and levodopa. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain.

• Levodopa is a dopamine replacement. Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain
• Carbidopa is a dopa decarboxylase inhibitor. Dopa decarboxylase is a protein in your body that breaks down levodopa before it can travel into your brain. By blocking this protein, carbidopa prevents levodopa from breaking down. This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances levodopa’s ability to relieve PD symptoms

Your provider will adjust your Rytary dose depending on how you respond to the medication.

• People who’ve never taken levodopa before: The typical starting dose is 23.75 mg/95 mg (carbidopa/levodopa) by mouth three times per day for the first 3 days. On the fourth day, the dose is raised to 36.25 mg/145 mg (carbidopa/levodopa) three times per day
• People switching from Sinemet (carbidopa / levodopa) to Rytary: The dose depends on your old Sinemet (carbidopa / levodopa) regimen

Rytary is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a nonselective MAO inhibitor.

Common side effects of Rytary:

• Nausea
• Dizziness
• Headache
• Trouble sleeping
• Unusual dreams
• Constipation
• Involuntary movements (dyskinesia)
• Anxiety
• Dry mouth
• Vomiting
• Drop in blood pressure when standing from a sitting or lying down position

Serious side effects are rare with Rytary. Contact your healthcare provider immediately if you experience any of the following.

• Withdrawal symptoms after stopping suddenly: confusion, very high fevers, irregular pulse, sweating, muscle stiffness, changes in blood pressure
• Heart problems: chest pain, arm pain, shortness of breath, cold sweat
• Suicidal thoughts or behavior

The following medications may interact with Rytary:

• Iron salts and dopamine D2 antagonists including metoclopramide: May reduce the effectiveness of Rytary

Amneal Pharmaceuticals

Based on animal data, Rytary may cause fetal harm. Notify your healthcare provider if you become pregnant or intend to become pregnant during Rytary therapy.

• Carbidopa/Levodopa