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Manufactured by Amneal Pharmaceuticals

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

RYTARY Uses, Side Effects, Interactions, Warnings & Dosing

What is RYTARY?

What is RYTARY?

RYTARY is the brand name for carbidopa and levodopa extended-release oral capsules.

What dosages is RYTARY available in?

What dosages is RYTARY available in?

RYTARY is available as an extended release carbidopa/levodopa capsules in strengths of 23.75 mg/95 mg, 36.25 mg/145 mg, 48.75 mg/195 mg, 61.25 mg/245 mg.

What is RYTARY used for?

What is RYTARY used for?

RYTARY is a dopa decarboxylase inhibitor/dopamine replacement that is used to treat:

  • Parkinson’s disease (PD)
  • Parkinsonism (conditions that cause people to have signs and symptoms found in PD, including slowness, stiffness, shakiness, and imbalance)
How does RYTARY work?

How does RYTARY work?

RYTARY is a combination of two medications: carbidopa and levodopa. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain.

  • Levodopa is a dopamine replacement. Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain
  • Carbidopa is a dopa decarboxylase inhibitor. Dopa decarboxylase is a protein in your body that breaks down levodopa before it can travel into your brain. By blocking this protein, carbidopa prevents levodopa from breaking down. This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances levodopa’s ability to relieve PD symptoms
How do I take RYTARY?

How do I take RYTARY?

Your provider will adjust your RYTARY dose depending on how you respond to the medication.

  • People who’ve never taken levodopa before: The typical starting dose is 23.75 mg/95 mg (carbidopa/levodopa) by mouth three times per day for the first 3 days. On the fourth day, the dose is raised to 36.25 mg/145 mg (carbidopa/levodopa) three times per day
  • People switching from Sinemet (carbidopa / levodopa) to RYTARY: The dose depends on your old Sinemet (carbidopa / levodopa) regimen
Is it safe for me to take RYTARY?

Is it safe for me to take RYTARY?

RYTARY is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are taking a nonselective MAO inhibitor.

RYTARY Common Side Effects

RYTARY Common Side Effects

Common side effects of RYTARY:

  • Nausea
  • Dizziness
  • Headache
  • Trouble sleeping
  • Unusual dreams
  • Constipation
  • Involuntary movements (dyskinesia)
  • Anxiety
  • Dry mouth
  • Vomiting
  • Drop in blood pressure when standing from a sitting or lying down position
RYTARY Serious Side Effects

RYTARY Serious Side Effects

Serious side effects are rare with RYTARY. Contact your healthcare provider immediately if you experience any of the following.

  • Withdrawal symptoms after stopping suddenly: confusion, very high fevers, irregular pulse, sweating, muscle stiffness, changes in blood pressure
  • Heart problems: chest pain, arm pain, shortness of breath, cold sweat
  • Suicidal thoughts or behavior
Effects of other drugs, drug classes and over-the-counter products on RYTARY

Effects of other drugs, drug classes and over-the-counter products on RYTARY

The following medications may interact with RYTARY:

  • Iron salts and dopamine D2 antagonists including metoclopramide: May reduce the effectiveness of RYTARY
Who makes RYTARY?

Who makes RYTARY?

Amneal Pharmaceuticals

Is RYTARY safe in pregnancy?

Is RYTARY safe in pregnancy?

Based on animal data, RYTARY may cause fetal harm. Notify your healthcare provider if you become pregnant or intend to become pregnant during RYTARY therapy.


What to do if you missed your RYTARY dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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