SINEMET CR
Used for Parkinson’s Disease
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Manufactured by Merck & Co., Inc.
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SINEMET CR Uses, Side Effects, Interactions, Warnings & Dosing
What is SINEMET CR?
SINEMET CR is the brand name for carbidopa/levadopa and is available as a sustained-release tablet.
What dosages is SINEMET CR available in?
SINEMET CR is available as a 25 mg/100 mg and 50 mg/200 mg sustained release tablet.
What is SINEMET CR used for?
SINEMET CR is a dopa decarboxylase inhibitor / dopamine replacement and is used to treat the following:
- Parkinson’s disease (PD)
- Parkinsonism (conditions that cause people to have signs and symptoms of PD, including slowness, stiffness, shakiness, and imbalance)
How does SINEMET CR work?
SINEMET CR is a combination of two medications: carbidopa and levodopa. By working together, these medications help relieve symptoms of Parkinson’s disease (PD), which occur due to low dopamine levels in the brain. Levodopa is a dopamine replacement.
Levodopa travels into your brain, where it’s converted into dopamine. It helps relieve PD symptoms by restoring dopamine in your brain. Carbidopa is a dopa decarboxylase inhibitor.
Dopa decarboxylase is a protein in your body that breaks down levodopa before it can travel into your brain. By blocking this protein, carbidopa prevents levodopa from breaking down.
This raises the level of levodopa in your body and allows more levodopa to travel into your brain to be converted into dopamine. Levodopa and dopamine can then reach and remain at higher levels in your brain, which enhances levodopa’s ability to relieve PD symptoms.
How do I take SINEMET CR?
SINEMET CR is typically started at 50 mg/200 mg (carbidopa/levodopa) by mouth 2 times per day at least 6 hours apart.
Is it safe for me to take SINEMET CR?
SINEMET CR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with SINEMET CR. These inhibitors must be discontinued at least two weeks prior to initiating therapy with SINEMET CR.
SINEMET CR Common Side Effects
Common side effects of SINEMET CR:
- Involuntary movements
- Nausea
SINEMET CR Serious Side Effects
Serious side effects are rare with SINEMET CR. Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome (NMS): very high fevers, confusion, irregular pulse, sweating, muscle stiffness, changes in blood pressure
Effects of other drugs, drug classes and over-the-counter products on SINEMET CR
The following medications may interact with SINEMET CR:
- Symptomatic postural hypotension has occurred when carbidopa levodopa preparations were added to
- the treatment of patients receiving some antihypertensive drugs
- Concomitant therapy with selegiline and carbidopa levodopa may be associated with severe orthostatic hypotension not attributable to carbidopa levodopa alone
- There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting
- from the concomitant use of tricyclic antidepressants and carbidopa levodopa preparations
- Dopamine D2 receptor antagonists (e.g., phenothiazines, butyrophenones, risperidone) and isoniazid may reduce the therapeutic effects of levodopa. In addition, the beneficial effects of levodopa in Parkinson’s disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with SINEMET CR should be carefully observed for loss of therapeutic response
- Use of SINEMET with dopamine-depleting agents (e.g., reserpine and tetrabenazine) or other drugs known to deplete monoamine stores is not recommended
- SINEMET CR and iron salts or multivitamins containing iron salts should be coadministered with caution. Iron salts can form chelates with levodopa and carbidopa and consequently reduce the bioavailability of carbidopa and levodopa
Who makes SINEMET CR?
Merck & Co., Inc.
Is SINEMET CR safe in pregnancy?
There are no adequate and well-controlled studies in pregnant women and SINEMET CR should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
What to do if you missed your SINEMET CR dose
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What does CR mean in Sinemet?
Can you break Sinemet CR in half?
What foods should be avoided when taking Sinemet?
How long does Sinemet CR stay in your system?
Is SR the same as CR?
Should Sinemet be taken at bedtime?
What is half Sinemet CR used for?
What's the difference between Sinemet and SINEMET CR?
How long does it take for Sinemet CR to start working?
Can you cut Sinemet CR in half?
Does Sinemet cause weight gain?
How long does Sinemet extended-release last?
What is a substitute for Sinemet?
Does Rytary work better than Sinemet?
Why was SINEMET CR discontinued?
Is Sinemet CR being discontinued?
Is there a substitute for Sinemet?
What happens when you suddenly stop taking Sinemet?
What are the side effects of Sinemet CR?
What drug interacts with Sinemet CR?
Can you take Sinemet CR four times a day?
What is the generic for Sinemet CR?
Why is Sinemet better than levodopa?
How long does it take for Sinemet CR to work?
Is Sinemet better than generic?
How long does Sinemet CR stay in the system?
Why is it important to take Sinemet on time?
What are the doses for SINEMET CR?
What are the signs of too much carbidopa-levodopa?
What is the best time of day to take Sinemet?
How many hours does Sinemet last?
What is the most common adverse reaction to Sinemet?
How often should Sinemet be given?
What is the most prominent side effect of Sinemet 25 100 mg?
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